Article
Medicine, Research & Experimental
Seung Yeob Hyun, Huong Thuy Le, Hye-Young Min, Honglan Pei, Yijae Lim, Injae Song, Yen T. K. Nguyen, Suckchang Hong, Byung Woo Han, Ho-Young Lee
Summary: The HSP system was found to be activated in CSCs, especially HSP70. Evo was identified to induce apoptosis in both CSC and non-CSC populations in various cancer cell lines. Mechanistically, Evo disrupted the HSP system by binding the N-terminal ATP-binding pocket of HSP70 and causing its ubiquitin-mediated degradation.
Article
Entomology
Shou-Min Fang, Qian Zhang, Yu-Li Zhang, Gui-Zheng Zhang, Ze Zhang, Quan-You Yu
Summary: The heat shock protein 70 family was identified in the whole genome of the silkworm, showing important roles in protecting against environmental stresses. The stress-inducible forms were found to play more crucial roles in adaptation to various stresses compared to the heat shock cognates.
Article
Biochemistry & Molecular Biology
Tal Belity, Michal Horowitz, Jay R. Hoffman, Yoram Epstein, Yaron Bruchim, Doron Todder, Hagit Cohen
Summary: Exposure to high ambient temperature can have extensive effects on brain structure and function. This study found that preconditioning with heat stress can improve resilience to predator-scent stress and may involve the induction of heat shock protein-70. Targeting this protein could be an attractive strategy for treating stress-related psychopathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jing Bai, Yu-Cheng Wang, Yun-Cai Liu, Ya-Wen Chang, Xiao-Na Liu, Wei-Rong Gong, Yu-Zhou Du
Summary: The heat shock protein 70 family (HSP70) is one of the most diverse HSP families in terms of structure and function. Two new HSP70 genes (Bthsp70-2 and Bthsp70-3) were isolated from the phloem-feeding insect Bemisia tabaci, and their expression patterns during thermal stress were found to differ, expanding the understanding of HSP roles in B. tabaci.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Plant Sciences
Koji Mikami, Ho Viet Khoa
Summary: Heat shock protein 70 (HSP70) is a conserved protein involved in maintaining protein folding and refolding in both prokaryotic and eukaryotic organisms. In the red alga Neopyropia yezoensis, we identified genes encoding HSP70 proteins in different cellular compartments. We found that membrane fluidization plays a role in the heat-induced expression of HSP70 genes in this alga. Our results suggest a unique regulatory system for heat-induced expression of HSP70 genes in N. yezoensis.
Article
Biochemistry & Molecular Biology
Jun-Yeun Cho, Seung-Jung Kim, Chang-Gok Woo, Soon-Kil Kwon, Kang-Hyeon Choe, Eung-Gook Kim, Yoon-Mi Shin
Summary: Altered lung HSP-70 expression is associated with the severity of sepsis-induced acute lung injury (ALI) in patients with chronic kidney disease (CKD). In the CKD group, the severity of sepsis-induced ALI was higher and enhanced lung HSP-70 expression was not observed. This study suggests that altered lung HSP-70 expression is related to the worsening of sepsis-induced ALI in CKD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Bolin Zhang, Huilei Sun, Zewei Sun, Ning Liu, Rujie Liu, Qingzhen Zhong
Summary: Glutamine (Gln) addition protects porcine epithelial cells (IPEC-J2) from apoptosis and damage to the mucosal barrier induced by heat stress (HS), potentially through the mitochondrial apoptosis pathway mediated by heat shock protein 70 (HSP70). These findings provide a possible theoretical basis for mitigating HS-induced damage to porcine intestinal epithelium and offer insights for developing nutritional strategies to alleviate the negative effects of HS on farmed animals.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Hyojae Son, Hee-Seon Choi, Seung Eun Baek, Yun-Hak Kim, Jin Hur, Jung-Hwa Han, Jeong Hee Moon, Ga Seul Lee, Sung Goo Park, Chang-Hoon Woo, Seong-Kug Eo, Sik Yoon, Byoung Soo Kim, Dongjun Lee, Koanhoi Kim
Summary: The loss of endothelial cells and the accumulation of monocytes/macrophages in the arteries are related to mechanical stimuli, such as shear stress. The study found that shear stress increased the expression of inflammatory chemokine CCL2 and the migration of monocytic cells. The surface levels of heat shock protein 70 (HSP70), HSP90, and HSP105 were also increased in response to shear stress, suggesting an association between HSPs and inflammatory responses. The regulation of these HSPs on the surface of monocytes/macrophages may serve as a potential therapeutic target for inflammation caused by shear stress.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Mingzu Guo, Wenxi Xu, Yoshinari Yamamoto, Takuya Suzuki
Summary: The study found that curcumin can increase the expression of HSP70 in intestinal Caco-2 cells through transcriptional activation, possibly enhancing cell integrity. The effects of curcumin are regulated by various signaling pathways. This discovery is expected to contribute to a deeper understanding of the regulation of intestinal HSP70 by dietary components.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Zifei Han, Shelli R. McAlpine, Robert Chapman
Summary: This study demonstrates the successful delivery of inhibitors to block the interaction between Hsp70 and HOP using polymer nanogels. The results show the effectiveness of these inhibitors in inhibiting Hsp70 and inducing cancer cell death.
BIOORGANIC CHEMISTRY
(2022)
Article
Agronomy
Chuanbei Tian, Yaying Li, Yixia Wu, Wenqiang Chu, Huai Liu
Summary: In fluctuating climatic environments, heat acclimation in predatory mites is a superior adaptation strategy for effective agricultural pest management. The sustained accumulation of HSP70 proteins results in predatory mites with thermotolerance advantage, promoting their biological control function to pests. The divergent constitutive regulation of HSP70 to a thermal environment allows predators to adapt flexibly to extreme stress.
PEST MANAGEMENT SCIENCE
(2021)
Article
Neurosciences
Zhongting Zhao, Zheng Li, Fangning Du, Yixin Wang, Yue Wu, Kah-leong Lim, Lin Li, Naidi Yang, Changmin Yu, Chengwu Zhang
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Misfolding, aggregation, and abnormal degradation of proteins are believed to be key factors in the pathogenesis of PD. Heat shock protein 70 (Hsp70) and Parkin, an E3 ubiquitin ligase, have been found to play important roles in PD pathogenesis. This review focuses on the dysregulation of Hsp70 and Parkin, their interaction, and their potential therapeutic applications in PD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hye-Young Min, Yijae Lim, Hyukjin Kwon, Hye-Jin Boo, Seung Yeob Hyun, Junhwa Hong, Suckchang Hong, Ho-Young Lee
Summary: The evodiamine derivative, EV408, has shown potent inhibitory effects on non-small cell lung cancer (NSCLC) cells by inducing apoptosis, suppressing colony formation and CSC population, and destabilizing HSP70 function. It also exhibited negligible toxicity on normal cells.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Environmental Sciences
Zhenjie Sun, Wenhui Gu, Zezhong Feng, Yaqin Fan, Jianfeng Niu, Guangce Wang
Summary: This study elucidated the expression regulation mechanism of the heat shock protein 70 gene in Neopyropia yezoensis under high temperature stress. The findings showed the involvement of cAMP-dependent protein kinase and activating transcription factors element in the transcription regulation of the gene. In addition, AMPK was also found to play a role in the induction of the gene. Furthermore, posttranscriptional mechanisms were proposed to be involved in the synthesis regulation of the heat shock protein 70-2 protein.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Biology
Sara Sannino, Megan E. Yates, Mark E. Schurdak, Steffi Oesterreich, Adrian Lee, Peter Wipf, Jeffrey L. Brodsky
Summary: Breast cancer cells exhibit varying levels of resistance to Hsp70 inhibition, with highly resistant cells showing increased levels of autophagy. Resistance to compromised Hsp70 function depends on the integrated stress response transducer GCN2, while sensitive cells activate PERK in response to Hsp70 inhibition.