Opportunities and Challenges with Stem Cell-Based Embryo Models

Evaluating totipotency using criteria of increasing stringency

(2021) Eszter Posfai et al.   NATURE CELL BIOLOGY

Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

(2020) Susanne C. van den Brink et al.   NATURE

Derivation of trophoblast stem cells from naïve human pluripotent stem cells

(2020) Chen Dong et al.   eLife

Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells

(2020) Insoo Hyun et al.   Stem Cell Reports

Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient

(2020) Pedro Rifes et al.   NATURE BIOTECHNOLOGY

Mechanisms of human embryo development: from cell fate to tissue shape and back

(2020) Marta N. Shahbazi   DEVELOPMENT

Modelling human embryogenesis: embryo-like structures spark ethical and policy debate

(2020) Ana M Pereira Daoud et al.   HUMAN REPRODUCTION UPDATE

Applications and ethics of computer-designed organisms

(2020) M. Levin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome

(2020) Jessica K. Cinkornpumin et al.   Stem Cell Reports

Pluripotent stem cell models of early mammalian development

(2020) Peter Baillie-Benson et al.   CURRENT OPINION IN CELL BIOLOGY

Experimental embryology of gastrulation: pluripotent stem cells as a new model system

(2020) Naomi Moris et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Initiation of a conserved trophectoderm program in human, cow and mouse embryos

(2020) Claudia Gerri et al.   NATURE

Reprogramming roadmap reveals route to human induced trophoblast stem cells

(2020) Xiaodong Liu et al.   NATURE

National human embryo and embryoid research policies: a survey of 22 top research-intensive countries

(2020) Kirstin RW Matthews et al.   Regenerative Medicine

Translating Embryogenesis to Generate Organoids: Novel Approaches to Personalized Medicine

(2020) Sounak Sahu et al.   iScience

Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells

(2020) Jonathon M. Muncie et al.   DEVELOPMENTAL CELL

Capturing Cardiogenesis in Gastruloids

(2020) Giuliana Rossi et al.   Cell Stem Cell

Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts

(2019) Hana Benchetrit et al.   Cell Stem Cell

Establishment of porcine and human expanded potential stem cells

(2019) Xuefei Gao et al.   NATURE CELL BIOLOGY

A novel self-organizing embryonic stem cell system reveals signaling logic underlying the patterning of human ectoderm

(2019) George Britton et al.   DEVELOPMENT

Reconstituting the transcriptome and DNA methylome landscapes of human implantation

(2019) Fan Zhou et al.   NATURE

Controlled modelling of human epiblast and amnion development using stem cells

(2019) Yi Zheng et al.   NATURE

Induced 2C Expression and Implantation-Competent Blastocyst-like Cysts from Primed Pluripotent Stem Cells

(2019) Cody Kime et al.   Stem Cell Reports

Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures

(2019) Ronghui Li et al.   CELL

Naïve human pluripotent stem cells respond to Wnt, Nodal and LIF signalling to produce expandable naïve extra-embryonic endoderm

(2019) Madeleine Linneberg-Agerholm et al.   DEVELOPMENT

Automated Design of Pluripotent Stem Cell Self-Organization

(2019) Ashley R.G. Libby et al.   Cell Systems

Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid

(2019) Berna Sozen et al.   DEVELOPMENTAL CELL

A developmental landscape of 3D-cultured human pre-gastrulation embryos

(2019) Lifeng Xiang et al.   NATURE

Derivation of Human Trophoblast Stem Cells

(2018) Hiroaki Okae et al.   Cell Stem Cell

Blastocyst-like structures generated solely from stem cells

(2018) Nicolas C. Rivron et al.   NATURE

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

(2018) Berna Sozen et al.   NATURE CELL BIOLOGY

Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells

(2018) Xufeng Xue et al.   NATURE MATERIALS

Exploring early human embryo development

(2018) Janet Rossant et al.   SCIENCE

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

(2018) Sophie M Morgani et al.   eLife

Self-organization of a human organizer by combined Wnt and Nodal signalling

(2018) I. Martyn et al.   NATURE

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

(2018) Leonardo Beccari et al.   NATURE

Debate ethics of embryo models from stem cells

(2018) Nicolas Rivron et al.   NATURE

Establishment of mouse expanded potential stem cells

(2017) Jian Yang et al.   NATURE

Genome editing reveals a role for OCT4 in human embryogenesis

(2017) Norah M. E. Fogarty et al.   NATURE

Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm

(2017) Kathryn G. V. Anderson et al.   NATURE CELL BIOLOGY

Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory

(2016) William A. Pastor et al.   Cell Stem Cell

Self-organization of the in vitro attached human embryo

(2016) Alessia Deglincerti et al.   NATURE

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Self-organization of human embryonic stem cells on micropatterns

(2016) Alessia Deglincerti et al.   Nature Protocols

Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass

(2016) Ge Guo et al.   Stem Cell Reports

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

(2014) Thorold W. Theunissen et al.   Cell Stem Cell

Developmental differences in the expression of FGF receptors between human and mouse embryos

(2014) T. Kunath et al.   PLACENTA

The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos

(2012) E. W. Kuijk et al.   DEVELOPMENT

Regulation of extra-embryonic endoderm stem cell differentiation by Nodal and Cripto signaling

(2011) M. K.-d. Julio et al.   DEVELOPMENT

Human hypoblast formation is not dependent on FGF signalling

(2011) Mila Roode et al.   DEVELOPMENTAL BIOLOGY

Naive and Primed Pluripotent States

(2009) Jennifer Nichols et al.   Cell Stem Cell

Stem Cells and Early Lineage Development

(2008) Janet Rossant   CELL