Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

Multiple roles of ATM in monitoring and maintaining DNA integrity

(2010) Frederick A. Derheimer et al.   FEBS LETTERS

Histone Deacetylase Inhibitors Activate NF-κB in Human Leukemia Cells through an ATM/NEMO-related Pathway

(2010) Roberto R. Rosato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RelB-Dependent Differential Radiosensitization Effect of STI571 on Prostate Cancer Cells

(2010) Yong Xu et al.   MOLECULAR CANCER THERAPEUTICS

SUMOylation-Dependent Localization of IKKɛ in PML Nuclear Bodies Is Essential for Protection against DNA-Damage-Triggered Cell Death

(2010) Florian Renner et al.   MOLECULAR CELL

RETRACTED: The Skp2 Promoter Integrates Signaling through the NF-κB, p53, and Akt/GSK3β Pathways to Regulate Autophagy and Apoptosis

(2010) Benjamin Barré et al.   MOLECULAR CELL

Nuclear IKKβ Is an Adaptor Protein for IκBα Ubiquitination and Degradation in UV-Induced NF-κB Activation

(2010) Yoshihiro Tsuchiya et al.   MOLECULAR CELL

AID-Induced Genotoxic Stress Promotes B Cell Differentiation in the Germinal Center via ATM and LKB1 Signaling

(2010) Mara H. Sherman et al.   MOLECULAR CELL

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

(2010) Zhao-Hui Wu et al.   MOLECULAR CELL

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

(2010) Michael Hinz et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

The Role of Ubiquitin in NF-κB Regulatory Pathways

(2009) Brian Skaug et al.   Annual Review of Biochemistry

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

NEMO oligomerization and its ubiquitin-binding properties

(2009) Frank J. Ivins et al.   BIOCHEMICAL JOURNAL

cIAP1, cIAP2, and XIAP Act Cooperatively via Nonredundant Pathways to Regulate Genotoxic Stress-Induced Nuclear Factor- B Activation

(2009) H.-S. Jin et al.   CANCER RESEARCH

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

(2009) Simin Rahighi et al.   CELL

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

(2009) H Christian Reinhardt et al.   CURRENT OPINION IN CELL BIOLOGY

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

(2009) E Laplantine et al.   EMBO JOURNAL

Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin

(2009) Azusa Yoshikawa et al.   FEBS LETTERS

Caspase-2 activation in the absence of PIDDosome formation

(2009) Claudia Manzl et al.   JOURNAL OF CELL BIOLOGY

DARPin-Assisted Crystallography of the CC2-LZ Domain of NEMO Reveals a Coupling between Dimerization and Ubiquitin Binding

(2009) Olivera Grubisha et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis for Recognition of Diubiquitins by NEMO

(2009) Yu-Chih Lo et al.   MOLECULAR CELL

A Nuclear Poly(ADP-Ribose)-Dependent Signalosome Confers DNA Damage-Induced IκB Kinase Activation

(2009) Michael Stilmann et al.   MOLECULAR CELL

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma

(2009) Etienne Meylan et al.   NATURE

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

(2009) Joanna R. Morris et al.   NATURE

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Stereological quantification of tumor volume, mean nuclear volume and total number of melanoma cells correlated with morbidity and mortality 

(2008) MARIE LOUISE BØNNELYKKE-BEHRNDTZ et al.   APMIS

NEMO shuttle: A link between DNA damage and NF-κB activation in progeroid syndromes?

(2008) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Crosstalk via the NF-κB signaling system

(2008) Soumen Basak et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Induction of a pro-apoptotic ATM–NF-κB pathway and its repression by ATR in response to replication stress

(2008) Zhao-Hui Wu et al.   EMBO JOURNAL

SUMO1 modification of NF-κB2/p100 is essential for stimuli-induced p100 phosphorylation and processing

(2008) Jaya Vatsyayan et al.   EMBO REPORTS

The Zinc Finger of NEMO Is a Functional Ubiquitin-binding Domain

(2008) Florence Cordier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SN52, a novel nuclear factor- B inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation

(2008) Y. Xu et al.   MOLECULAR CANCER THERAPEUTICS

Crystal Structure of a vFlip-IKKγ Complex: Insights into Viral Activation of the IKK Signalosome

(2008) Claire Bagnéris et al.   MOLECULAR CELL

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

(2008) Andrea L. Bredemeyer et al.   NATURE

Ionizing radiation-induced NF-κB activation requires PARP-1 function to confer radioresistance

(2008) S J Veuger et al.   ONCOGENE

ATM mediates constitutive NF-κB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia

(2008) J Grosjean-Raillard et al.   ONCOGENE

Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site

(2008) Mia Rushe et al.   STRUCTURE