2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury

RIP3 deficiency protects against traumatic brain injury (TBI) through suppressing oxidative stress, inflammation and apoptosis: Dependent on AMPK pathway

(2018) Zai-Ming Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The imidazoline I 2 receptor agonist 2-BFI attenuates hypersensitivity and spinal neuroinflammation in a rat model of neuropathic pain

(2018) Justin N. Siemian et al.   BIOCHEMICAL PHARMACOLOGY

RIPK3/MLKL-Mediated Neuronal Necroptosis Modulates the M1/M2 Polarization of Microglia/Macrophages in the Ischemic Cortex

(2018) Jiping Yang et al.   CEREBRAL CORTEX

RACK1 upregulation induces neuroprotection by activating the IRE1-XBP1 signaling pathway following traumatic brain injury in rats

(2018) Haibo Ni et al.   EXPERIMENTAL NEUROLOGY

Inflammasome: Its role in traumatic brain and spinal cord injury

(2018) Keywan Mortezaee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

2-(2-benzofuranyl)-2-imidazoline (2-BFI) improved the impairments in AD rat models by inhibiting oxidative stress, inflammation and apoptosis

(2018) Ji-Sha Tian et al.   Journal of Integrative Neuroscience

MCC950, the Selective Inhibitor of Nucleotide Oligomerization Domain-Like Receptor Protein-3 Inflammasome, Protects Mice against Traumatic Brain Injury

(2018) Saifudeen Ismael et al.   JOURNAL OF NEUROTRAUMA

Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury

(2018) Xin Xu et al.   NEUROBIOLOGY OF DISEASE

The protective effect of 2-(2-benzonfu-ranyl)-2-imidazoline against oxygen-glucose deprivation in cultured rat cortical astrocytes

(2018) Jisha Tian et al.   NEUROSCIENCE RESEARCH

LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats

(2018) Qin Rui et al.   Frontiers in Cellular Neuroscience

Imidazoline I 2 receptors: An update

(2017) Jun-Xu Li   PHARMACOLOGY & THERAPEUTICS

Lack of the Nlrp3 Inflammasome Improves Mice Recovery Following Traumatic Brain Injury

(2017) Natasha Irrera et al.   Frontiers in Pharmacology

Therapies negating neuroinflammation after brain trauma

(2016) Sarah Hellewell et al.   BRAIN RESEARCH

Cerebral Edema in Traumatic Brain Injury

(2016) Ethan A. Winkler et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat

(2016) Tao Liu et al.   Scientific Reports

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

(2015) Francis Ka-Ming Chan et al.   Annual Review of Immunology

Delayed Increases in Microvascular Pathology after Experimental Traumatic Brain Injury Are Associated with Prolonged Inflammation, Blood–Brain Barrier Disruption, and Progressive White Matter Damage

(2014) Olena Y. Glushakova et al.   JOURNAL OF NEUROTRAUMA

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Brain Protection Conferred by Long-Term Administration of 2-(2-Benzofuranyl)-2-Imidazoline Against Experimental Autoimmune Encephalomyelitis

(2014) Ying-Biao Zhu et al.   NEUROCHEMICAL RESEARCH

Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model

(2013) Huan-Dong Liu et al.   NEUROCHEMICAL RESEARCH

Fast, Non-Competitive and Reversible Inhibition of NMDA-Activated Currents by 2-BFI Confers Neuroprotection

(2013) Zhao Han et al.   PLoS One

Microglia Activation as a Biomarker for Traumatic Brain Injury

(2013) Diana G. Hernandez-Ontiveros et al.   Frontiers in Neurology

Neurovascular protection conferred by 2-BFI treatment during rat cerebral ischemia

(2012) Zhao Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention

(2012) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

2-BFI ameliorates EAE-induced mouse spinal cord damage: Effective therapeutic time window and possible mechanisms

(2012) Fang Li et al.   BRAIN RESEARCH

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

2-BFI attenuates experimental autoimmune encephalomyelitis-induced spinal cord injury with enhanced B-CK, CaATPase, but reduced calpain activity

(2011) Pei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Morphine-induced antinociception in the rat: Supra-additive interactions with imidazoline I2 receptor ligands

(2011) Jun-Xu Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Blood–Brain Barrier Pathophysiology in Traumatic Brain Injury

(2011) Adam Chodobski et al.   Translational Stroke Research

2-(-2-benzofuranyl)-2-imidazoline induces Bcl-2 expression and provides neuroprotection against transient cerebral ischemia in rats

(2010) Zhao Han et al.   BRAIN RESEARCH

Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments

(2010) James J Donkin et al.   CURRENT OPINION IN NEUROLOGY

The Epidemiology of Traumatic Brain Injury

(2010) John D. Corrigan et al.   JOURNAL OF HEAD TRAUMA REHABILITATION

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

(2010) Dan Shlosberg et al.   Nature Reviews Neurology

Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury

(2010) Jenna M. Ziebell et al.   Neurotherapeutics

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2008) Zerong You et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Zinc Triggers Microglial Activation

(2008) T. M. Kauppinen et al.   JOURNAL OF NEUROSCIENCE