Cooperative N-heterocyclic Carbene and Iridium Catalysis Enables Stereoselective and Regiodivergent [3 + 2] and [3 + 3] Annulation Reactions

Pseudo-Stereodivergent Synthesis of Enantioenriched Tetrasubstituted Alkenes via Cascade 1,3-Oxo-Allylation/Cope Rearrangement

(2020) Ying-Chun Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bifunctional N-Heterocyclic Carbenes Derived from l-Pyroglutamic Acid and Their Applications in Enantioselective Organocatalysis

(2020) Xiang-Yu Chen et al.   ACCOUNTS OF CHEMICAL RESEARCH

N ‐Heterocyclic carbene organocatalysis: activation modes and typical reactive intermediates

(2020) Xingkuan Chen et al.   CHINESE JOURNAL OF CHEMISTRY

NHC/Copper-Cocatalyzed [4 + 3] Annulations of Salicylaldehydes with Aziridines for the Synthesis of 1,4-Benzoxazepinones

(2020) You-Feng Han et al.   ORGANIC LETTERS

Synergistic N-Heterocyclic Carbene/Palladium-Catalyzed [3 + 2] Annulation of Vinyl Enolates with 1-Tosyl-2-vinylaziridine

(2020) Jian Gao et al.   ORGANIC LETTERS

Catalytic asymmetric dipolar cycloadditions of indolyl delocalized metal-allyl species for the enantioselective synthesis of cyclopenta [b]indoles and pyrrolo[1,2-a]indoles

(2020) Fei Tian et al.   Science China-Chemistry

Kinetic Resolution of Aziridines Enabled by N‐Heterocyclic Carbene/Copper Cooperative Catalysis: Carbene Dose‐Controlled Chemo‐Switchability

(2020) Zi‐Jing Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene/Magnesium Cocatalyzed Radical Relay Assembly of Aliphatic Keto Nitriles

(2020) Lei Chen et al.   ORGANIC LETTERS

NHC-Catalyzed Generation of α,β-Unsaturated Acylazoliums for the Enantioselective Synthesis of Heterocycles and Carbocycles

(2019) Santigopal Mondal et al.   ACCOUNTS OF CHEMICAL RESEARCH

Iridium-Catalyzed Asymmetric Synthesis of Functionally Rich Molecules Enabled by (Phosphoramidite,Olefin) Ligands

(2019) Simon L. Rössler et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-Heterocyclic Carbene/Copper Cooperative Catalysis for the Asymmetric Synthesis of Spirooxindoles

(2019) Zi-Jing Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzed Enantioselective Allylic Substitution with Aqueous Solutions of Nucleophiles

(2019) Tobias Sandmeier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synergetic iridium and amine catalysis enables asymmetric [4+2] cycloadditions of vinyl aminoalcohols with carbonyls

(2019) Mao-Mao Zhang et al.   Nature Communications

Synergistic N-Heterocyclic Carbene/Palladium-Catalyzed Umpolung 1,4-Addition of Aryl Iodides to Enals

(2019) Wenjun Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cooperative Tertiary Amine/Chiral Iridium Complex Catalyzed Asymmetric [4+3] and [3+3] Annulation Reactions

(2019) Zhi-Chao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (−)-Alstoscholarine

(2019) Jian-Neng Yao et al.   ORGANIC LETTERS

N-Heterocyclic Carbene (NHC)/Metal Cooperative Catalysis

(2019) Kazunori Nagao et al.   Topics in Current Chemistry

Gold and Carbene Relay Catalytic Enantioselective Cycloisomerization/Cyclization Reactions of Ynamides and Enals

(2019) Liejin Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction

(2019) Shi-Ming Xu et al.   Nature Communications

Diastereodivergent synthesis of enantioenriched α,β-disubstituted γ-butyrolactones via cooperative N-heterocyclic carbene and Ir catalysis

(2019) Santanu Singha et al.   Nature Catalysis

Synergistic N-Heterocyclic Carbene/Palladium-Catalyzed Reactions of Aldehyde Acyl Anions with either Diarylmethyl or Allylic Carbonates

(2018) Shigeo Yasuda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalysis via Azolium Dienolates: An Efficient Strategy for Remote Enantioselective Functionalizations

(2018) Xiang-Yu Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones

(2018) Kathleen J. R. Murauski et al.   CHEMICAL SOCIETY REVIEWS

Aerobic Oxidation/Annulation Cascades via Synergistic Catalysis of RuCl3 and N-Heterocyclic Carbenes

(2018) Qian Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Stereodivergent Synthesis of α,α-Disubstituted α-Amino Acids via Synergistic Cu/Ir Catalysis

(2018) Liang Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Enantioselective [5 + 2] Annulations through Cooperative N-Heterocyclic Carbene (NHC) Organocatalysis and Palladium Catalysis

(2018) Santanu Singha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Allylation of Azaaryl Acetamides and Acetates by Synergistic Iridium and Copper Catalysis

(2018) Xingyu Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters

(2018) Xiaohong Huo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective palladium-catalyzed allylic alkylation reactions in the synthesis of Aspidosperma and structurally related monoterpene indole alkaloids

(2018) Beau P. Pritchett et al.   NATURAL PRODUCT REPORTS

Iridium-Catalyzed Asymmetric Allylic Substitution Reactions

(2018) Qiang Cheng et al.   CHEMICAL REVIEWS

Mechanistic Studies on a Cooperative NHC Organocatalysis/Palladium Catalysis System: Uncovering Significant Lessons for Mixed Chiral Pd(NHC)(PR3) Catalyst Design

(2017) Chang Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergence in Asymmetric Catalysis

(2017) Simon Krautwald et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent progress in organocatalytic asymmetric total syntheses of complex indole alkaloids

(2017) Jin Song et al.   National Science Review

Combinations of Aminocatalysts and Metal Catalysts: A Powerful Cooperative Approach in Selective Organic Synthesis

(2016) Samson Afewerki et al.   CHEMICAL REVIEWS

An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones

(2016) Xiaohong Huo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperative N-Heterocyclic Carbene/Palladium-Catalyzed Enantioselective Umpolung Annulations

(2016) Chang Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Allylic Substitutions with Aryl Acetic Acid Esters by Synergistic Iridium and Lewis Base Catalysis

(2016) Xingyu Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-Assisted, Iridium-Catalyzed Allylation of Bis[(pinacolato)boryl]methane Allows the Synthesis of Enantioenriched Homoallylic Organoboronic Esters

(2016) Miao Zhan et al.   ACS Catalysis

Iridium-Catalyzed Diastereo-, Enantio-, and Regioselective Allylic Alkylation with Prochiral Enolates

(2016) J. Caleb Hethcox et al.   ACS Catalysis

Asymmetric γ-Allylation of α,β-Unsaturated Aldehydes by Combined Organocatalysis and Transition-Metal Catalysis

(2015) Line Naesborg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

A review on recent developments of indole-containing antiviral agents

(2015) Ming-Zhi Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Origin of Stereodivergence in Cooperative Asymmetric Catalysis with Simultaneous Involvement of Two Chiral Catalysts

(2015) Bangaru Bhaskararao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Switchable selectivity in an NHC-catalysed dearomatizing annulation reaction

(2015) Chang Guo et al.   Nature Chemistry

Asymmetric Organocatalysis Combined with Metal Catalysis: Concept, Proof of Concept, and Beyond

(2014) Dian-Feng Chen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Dual-function Pd/NHC catalysis: tandem allylation–isomerization–conjugate addition that allows access to pyrroles, thiophenes and furans

(2014) Yaguang Bai et al.   CHEMICAL COMMUNICATIONS

Stereodivergent α-Allylation of Linear Aldehydes with Dual Iridium and Amine Catalysis

(2014) Simon Krautwald et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

A cooperative N-heterocyclic carbene/palladium catalysis system

(2014) Kun Liu et al.   Chemical Science

Metal and carbene organocatalytic relay activation of alkynes for stereoselective reactions

(2014) Kayambu Namitharan et al.   Nature Communications

Cooperative N-Heterocyclic Carbene (NHC) and Ruthenium Redox Catalysis: Oxidative Esterification of Aldehydes with Air as the Terminal Oxidant

(2013) Junfeng Zhao et al.   ADVANCED SYNTHESIS & CATALYSIS

Acyl anion free N-heterocyclic carbene organocatalysis

(2013) Sarah J. Ryan et al.   CHEMICAL SOCIETY REVIEWS

A New Twist on Cooperative Catalysis

(2013) C. S. Schindler et al.   SCIENCE

Enantio- and Diastereodivergent Dual Catalysis:  -Allylation of Branched Aldehydes

(2013) S. Krautwald et al.   SCIENCE

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

Combining transition metal catalysis and organocatalysis – an update

(2012) Zhenting Du et al.   CHEMICAL SOCIETY REVIEWS

Iridium-Catalyzed Allylic Alkylation Reaction with N-Aryl Phosphoramidite Ligands: Scope and Mechanistic Studies

(2012) Wen-Bo Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed Enantioselective Allylic Vinylation

(2012) James Y. Hamilton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synergistic catalysis: A powerful synthetic strategy for new reaction development

(2012) Anna E. Allen et al.   Chemical Science

Mechanistically Driven Development of Iridium Catalysts for Asymmetric Allylic Substitution

(2010) John F. Hartwig et al.   ACCOUNTS OF CHEMICAL RESEARCH