Machine learning identifies candidates for drug repurposing in Alzheimer’s disease
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Machine learning identifies candidates for drug repurposing in Alzheimer’s disease
Authors
Keywords
-
Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-02-17
DOI
10.1038/s41467-021-21330-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
- (2020) Yingyue Zhou et al. NATURE MEDICINE
- The harmonic mean p-value for combining dependent tests
- (2019) Daniel J. Wilson PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line
- (2019) Yuyu Song et al. Scientific Data
- A core transcriptional signature of human microglia: Derivation and utility in describing region-dependent alterations associated with Alzheimer's disease
- (2019) Anirudh Patir et al. GLIA
- Protective effect of Tenuifolin against Alzheimer’s disease
- (2019) Lin Wang et al. NEUROSCIENCE LETTERS
- Drug repurposing for Alzheimer’s disease based on transcriptional profiling of human iPSC-derived cortical neurons
- (2019) Gareth Williams et al. Translational Psychiatry
- Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
- (2019) Justin M. Long et al. CELL
- Avoidable flaws in observational analyses: an application to statins and cancer
- (2019) Barbra A. Dickerman et al. NATURE MEDICINE
- Evidence of a Causal Association Between Cancer and Alzheimer’s Disease: a Mendelian Randomization Analysis
- (2019) Sahba Seddighi et al. Scientific Reports
- Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia
- (2019) Oliver H. Tam et al. Cell Reports
- Gene Expression-Based Drug Repurposing to Target Ageing
- (2018) Handan Melike Dönertaş et al. AGING CELL
- Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases
- (2018) Mariet Allen et al. Alzheimers & Dementia
- Person-specific contribution of neuropathologies to cognitive loss in old age
- (2018) Patricia A. Boyle et al. ANNALS OF NEUROLOGY
- L1000FWD: fireworks visualization of drug-induced transcriptomic signatures
- (2018) Zichen Wang et al. BIOINFORMATICS
- A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease
- (2018) Joseph Park et al. NATURE NEUROSCIENCE
- A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease
- (2018) Sara Mostafavi et al. NATURE NEUROSCIENCE
- Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer’s disease
- (2018) Rachel E. Bennett et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Network-based approach to prediction and population-based validation of in silico drug repurposing
- (2018) Feixiong Cheng et al. Nature Communications
- Structural absorption by barbule microstructures of super black bird of paradise feathers
- (2018) Dakota E. McCoy et al. Nature Communications
- Current Strategies for Brain Drug Delivery
- (2018) Xiaowei Dong Theranostics
- Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models
- (2018) Michiko Sekiya et al. Genome Medicine
- Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models
- (2018) Khaled S. Abd-Elrahman et al. Molecular Brain
- Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy
- (2018) Mariet Allen et al. ACTA NEUROPATHOLOGICA
- Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility
- (2018) Towfique Raj et al. NATURE GENETICS
- Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies
- (2018) Patricia A. Boyle et al. ANNALS OF NEUROLOGY
- Drug repurposing: progress, challenges and recommendations
- (2018) Sudeep Pushpakom et al. NATURE REVIEWS DRUG DISCOVERY
- Translating the biology of aging into novel therapeutics for Alzheimer disease
- (2018) Yuko Hara et al. NEUROLOGY
- The mammalian ULK1 complex and autophagy initiation
- (2017) Maria Zachari et al. Essays in Biochemistry
- Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents
- (2017) Marie Jouanne et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015
- (2017) Dev Mehta et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Candidate novel long noncoding RNAs, MicroRNAs and putative drugs for Parkinson's disease using a robust and efficient genome-wide association study
- (2017) Zahra Mortezaei et al. GENOMICS
- Single-Base Resolution Mapping of 5-Hydroxymethylcytosine Modifications in Hippocampus of Alzheimer’s Disease Subjects
- (2017) Elizabeth M. Ellison et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Type-I interferon pathway in neuroinflammation and neurodegeneration: focus on Alzheimer’s disease
- (2017) Juliet M. Taylor et al. JOURNAL OF NEURAL TRANSMISSION
- Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease
- (2017) Andrew T. McKenzie et al. Molecular Neurodegeneration
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- Power analysis of single-cell RNA-sequencing experiments
- (2017) Valentine Svensson et al. NATURE METHODS
- Systematic integration of biomedical knowledge prioritizes drugs for repurposing
- (2017) Daniel Scott Himmelstein et al. eLife
- A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease
- (2017) Nicholas T. Seyfried et al. Cell Systems
- Determining the Molecular Pathways Underlying the Protective Effect of Non-Steroidal Anti-Inflammatory Drugs for Alzheimer's Disease: A Bioinformatics Approach
- (2017) Alejo J Nevado-Holgado et al. Computational and Structural Biotechnology Journal
- p70 S6 Kinase and Tau in Alzheimer's Disease
- (2017) Jin-Jing Pei et al. JOURNAL OF ALZHEIMERS DISEASE
- Drug Repositioning for Alzheimer’s Disease Based on Systematic ‘omics’ Data Mining
- (2017) Ming Zhang et al. PLoS One
- RapMap: a rapid, sensitive and accurate tool for mapping RNA-seq reads to transcriptomes
- (2016) Avi Srivastava et al. BIOINFORMATICS
- Accelerating Medicines Partnership: Alzheimer’s Disease (AMP-AD) Knowledge Portal Aids Alzheimer’s Drug Discovery through Open Data Sharing
- (2016) Richard J. Hodes et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- MeSHDD: Literature-based drug-drug similarity for drug repositioning
- (2016) Adam S Brown et al. JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
- The ChEMBL database in 2017
- (2016) Anna Gaulton et al. NUCLEIC ACIDS RESEARCH
- Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease
- (2016) Minghui Wang et al. Genome Medicine
- Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
- (2016) Kelly Regan et al. Jove-Journal of Visualized Experiments
- Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks
- (2016) Venkatesh Mallikarjun et al. EBioMedicine
- Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease
- (2015) A. Caccamo et al. JOURNAL OF NEUROSCIENCE
- Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease
- (2015) Elizabeta Gjoneska et al. NATURE
- Autophagy in Alzheimer’s disease
- (2015) Ameneh Zare-shahabadi et al. REVIEWS IN THE NEUROSCIENCES
- Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
- (2013) Thomas H. Marsilje et al. JOURNAL OF MEDICINAL CHEMISTRY
- Alzheimer disease in the United States (2010-2050) estimated using the 2010 census
- (2013) L. E. Hebert et al. NEUROLOGY
- U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease
- (2013) B. Bai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AlzPathway: a comprehensive map of signaling pathways of Alzheimer’s disease
- (2012) Satoshi Mizuno et al. BMC Systems Biology
- Drug repositioning for Alzheimer's disease
- (2012) Anne Corbett et al. NATURE REVIEWS DRUG DISCOVERY
- The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy
- (2011) Eun-Ju Lee et al. Autophagy
- PREDICT: a method for inferring novel drug indications with application to personalized medicine
- (2011) A. Gottlieb et al. Molecular Systems Biology
- An experimental comparison of cross-validation techniques for estimating the area under the ROC curve
- (2010) Antti Airola et al. COMPUTATIONAL STATISTICS & DATA ANALYSIS
- Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy
- (2010) Hong-Wen Tang et al. EMBO JOURNAL
- Cell “Self-Eating” (Autophagy) Mechanism in Alzheimer's Disease
- (2010) Sarah F. Funderburk et al. MOUNT SINAI JOURNAL OF MEDICINE
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons
- (2009) J. Chang et al. JOURNAL OF CELL SCIENCE
- A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging
- (2008) J. A. Miller et al. JOURNAL OF NEUROSCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search