Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models

mGluR5 antagonism increases autophagy and prevents disease progression in thezQ175mouse model of Huntington’s disease

(2017) Khaled S. Abd-Elrahman et al.   Science Signaling

mGluR5 antagonism increases autophagy and prevents disease progression in thezQ175mouse model of Huntington’s disease

(2017) Khaled S. Abd-Elrahman et al.   Science Signaling

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Chronic Pharmacological mGluR5 Inhibition Prevents Cognitive Impairment and Reduces Pathogenesis in an Alzheimer Disease Mouse Model

(2016) Alison Hamilton et al.   Cell Reports

Efficacy and Safety of Basimglurant as Adjunctive Therapy for Major Depression

(2016) Jorge A. Quiroz et al.   JAMA Psychiatry

Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach

(2015) Jihoon Nah et al.   MOLECULES AND CELLS

Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes

(2015) Alison Hamilton et al.   Molecular Brain

Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease

(2014) Alison Hamilton et al.   Molecular Brain

Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease

(2013) Fabiola M. Ribeiro et al.   HUMAN MOLECULAR GENETICS

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Neuronal Autophagy and Neurodevelopmental Disorders

(2013) Kyung-Min Lee et al.   Experimental Neurobiology

Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links

(2011) D. K. Sokol et al.   NEUROLOGY

Metabotropic Glutamate Receptor-Mediated Cell Signaling Pathways Are Altered in a Mouse Model of Huntington's Disease

(2010) F. M. Ribeiro et al.   JOURNAL OF NEUROSCIENCE

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Review: Therapy for Alzheimer's disease: how effective are current treatments?

(2009) Krista L. Lanctôt et al.   Therapeutic Advances in Neurological Disorders

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

Small molecule enhancers of autophagy for neurodegenerative diseases

(2008) Sovan Sarkar et al.   Molecular BioSystems