An immune epigenetic insight to COVID-19 infection

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study

(2020) Joseph T Wu et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

On the origin and continuing evolution of SARS-CoV-2

(2020) Xiaolu Tang et al.   National Science Review

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Angiotensin‐converting enzyme 2 in severe acute respiratory syndrome coronavirus and SARS‐CoV‐2: A double‐edged sword?

(2020) Tiantian Yan et al.   FASEB JOURNAL

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

(2020) Yonggang Zhou et al.   National Science Review

Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients

(2020) Amr H. Sawalha et al.   CLINICAL IMMUNOLOGY

COVID-19 pathophysiology: A review

(2020) Koichi Yuki et al.   CLINICAL IMMUNOLOGY

Is a “Cytokine Storm” Relevant to COVID-19?

(2020) Pratik Sinha et al.   JAMA Internal Medicine

Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

(2020) Matthijs Kox et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibition of HDAC Enzymes Contributes to Differential Expression of Pro-Inflammatory Proteins in the TLR-4 Signaling Cascade

(2020) Ulrike Weiss et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic modification is regulated by the interaction of influenza A virus nonstructural protein-1 with the de novo DNA methyltransferase DNMT3B and subsequent transport to the cytoplasm for K48-linked polyubiquitination

(2019) Shi Liu et al.   JOURNAL OF VIROLOGY

Epigenetic control of the angiotensin-converting enzyme in endothelial cells during inflammation

(2019) Thomas Mudersbach et al.   PLoS One

Middle East Respiratory Syndrome Coronavirus-Encoded Accessory Proteins Impair MDA5-and TBK1-Mediated Activation of NF-��B

(2019) Jeong Yoon Lee et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Modulation of Type-I Interferon Response by hsa-miR-374b-5p During Japanese Encephalitis Virus Infection in Human Microglial Cells

(2019) Meghana Rastogi et al.   Frontiers in Cellular and Infection Microbiology

The Porcine Deltacoronavirus Replication Organelle Comprises Double-Membrane Vesicles and Zippered Endoplasmic Reticulum with Double-Membrane Spherules

(2019) Nicole Doyle et al.   Viruses-Basel

The DOT1L inhibitor Pinometostat decreases the host-response against infections: Considerations about its use in human therapy

(2019) Laura Marcos-Villar et al.   Scientific Reports

Epigenetics and the dynamics of chromatin during adenovirus infections

(2019) Kelsey L. Lynch et al.   FEBS LETTERS

Epigenetic stabilization of DC and DC precursor classical activation by TNFα contributes to protective T cell polarization

(2019) Alison J. Eastman et al.   Science Advances

Immuno-metabolic changes in herpes virus infection

(2018) Debprasad Chattopadhyay et al.   CYTOKINE

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

(2018) Vineet D. Menachery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival

(2018) Shaoni Bhattacharjee et al.   Cell Death & Disease

Viral miRNAs Alter Host Cell miRNA Profiles and Modulate Innate Immune Responses

(2018) Afsar R. Naqvi et al.   Frontiers in Immunology

A motif in HSP90 and P23 that links molecular chaperones to efficient estrogen receptor α methylation by the lysine methyltransferase SMYD2

(2018) Wolfgang M. J. Obermann   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of NF-κB Activity: A Viral Immune Evasion Mechanism

(2018) Liyao Deng et al.   Viruses-Basel

Epigenetic control of influenza virus: role of H3K79 methylation in interferon-induced antiviral response

(2018) Laura Marcos-Villar et al.   Scientific Reports

Epigenetics and Metabolism in Health and Disease

(2018) Evangelia Tzika et al.   Frontiers in Genetics

Epigenome-wide analysis of DNA methylation in lung tissue shows concordance with blood studies and identifies tobacco smoke-inducible enhancers

(2017) Theresa Ryan Stueve et al.   HUMAN MOLECULAR GENETICS

The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses

(2017) Barbara Hummel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses

(2017) Barbara Hummel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells

(2017) Michael Poppe et al.   PLoS Pathogens

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

(2016) Bonnie R. Joubert et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ebola virus encodes a miR-155 analog to regulate importin-α5 expression

(2016) Yuanwu Liu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy is involved in regulating influenza A virus RNA and protein synthesis associated with both modulation of Hsp90 induction and mTOR/p70S6K signaling pathway

(2016) Ge Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Chronic hepatitis B virus and hepatitis C virus infections and cancer: synergy between viral and host factors

(2015) V. Schinzari et al.   CLINICAL MICROBIOLOGY AND INFECTION

The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses

(2015) Gernot Wolf et al.   GENES & DEVELOPMENT

Epigenetic modifications of the immune system in health and disease

(2015) Yuuki Obata et al.   IMMUNOLOGY AND CELL BIOLOGY

Promoter Hypermethylation Profiling Identifies Subtypes of Head and Neck Cancer with Distinct Viral, Environmental, Genetic and Survival Characteristics

(2015) Javed Hussain Choudhury et al.   PLoS One

Comprehensive DNA methylation analysis of hepatitis B virus genome in infected liver tissues

(2015) Surbhi Jain et al.   Scientific Reports

Epstein-Barr Virus Proteins EBNA3A and EBNA3C Together Induce Expression of the Oncogenic MicroRNA Cluster miR-221/miR-222 and Ablate Expression of Its Target p57KIP2

(2015) Quentin Bazot et al.   PLoS Pathogens

HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells

(2015) Jonathan E Reeder et al.   eLife

T cell-mediated immune response to respiratory coronaviruses

(2014) Rudragouda Channappanavar et al.   IMMUNOLOGIC RESEARCH

Regulatory role of TRIM21 in the type-I interferon pathway in Japanese encephalitis virus-infected human microglial cells

(2014) Gunjan Manocha et al.   Journal of Neuroinflammation

The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection

(2014) Christopher Schliehe et al.   NATURE IMMUNOLOGY

Systematic CpT (ApG) Depletion and CpG Excess Are Unique Genomic Signatures of Large DNA Viruses Infecting Invertebrates

(2014) Mohita Upadhyay et al.   PLoS One

Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus

(2014) Ming Yip et al.   Virology Journal

Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

(2014) V. D. Menachery et al.   mBio

HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene

(2013) Marjorie Pion et al.   AIDS

Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress

(2013) Nicola E. Clarke et al.   CLINICAL SCIENCE

Hepatitis Virus Infection Affects DNA Methylation in Mice With Humanized Livers

(2013) Yasuyuki Okamoto et al.   GASTROENTEROLOGY

Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication

(2013) Ayami Sato et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

miR-146a facilitates replication of dengue virus by dampening interferon induction by targeting TRAF6

(2013) Siyu Wu et al.   JOURNAL OF INFECTION

Rational Design of a Flavivirus Vaccine by Abolishing Viral RNA 2'-O Methylation

(2013) S.-H. Li et al.   JOURNAL OF VIROLOGY

Genomic and Epigenomic Cross-talks in the Regulatory Landscape of miRNAs in Breast Cancer

(2013) Devyani Samantarrai et al.   MOLECULAR CANCER RESEARCH

Reactivation of latent HIV by histone deacetylase inhibitors

(2013) Kotaro Shirakawa et al.   TRENDS IN MICROBIOLOGY

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Proteins 3, 4, and 6 Induce Double-Membrane Vesicles

(2013) M. M. Angelini et al.   mBio

Sequestration by IFIT1 Impairs Translation of 2′O-unmethylated Capped RNA

(2013) Matthias Habjan et al.   PLoS Pathogens

Adenovirus Evasion of Interferon-Mediated Innate Immunity by Direct Antagonism of a Cellular Histone Posttranslational Modification

(2012) G.J. Fonseca et al.   Cell Host & Microbe

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

Orderly order in protein intrinsic disorder distribution: disorder in 3500 proteomes from viruses and the three domains of life

(2012) Bin Xue et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Identification of Host-Chromosome Binding Sites and Candidate Gene Targets for Kaposi's Sarcoma-Associated Herpesvirus LANA

(2012) F. Lu et al.   JOURNAL OF VIROLOGY

Suppression of the antiviral response by an influenza histone mimic

(2012) Ivan Marazzi et al.   NATURE

SARS Coronavirus 3b Accessory Protein Modulates Transcriptional Activity of RUNX1b

(2012) Bhavna Varshney et al.   PLoS One

The Role of Bromodomain Proteins in Regulating Gene Expression

(2012) Gabrielle A. Josling et al.   Genes

Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents

(2011) S. K. Ghosh et al.   BLOOD

An Identical miRNA of the Human JC and BK Polyoma Viruses Targets the Stress-Induced Ligand ULBP3 to Escape Immune Elimination

(2011) Yoav Bauman et al.   Cell Host & Microbe

The DNA methyltranferase Dnmt2 participates in RNA processing during cellular stress

(2011) Devi Thiagarajan et al.   Epigenetics

Kaposi's Sarcoma-Associated Herpesvirus Noncoding Polyadenylated Nuclear RNA Interacts with Virus- and Host Cell-Encoded Proteins and Suppresses Expression of Genes Involved in Immune Modulation

(2011) C. C. Rossetto et al.   JOURNAL OF VIROLOGY

The Avian Influenza Virus NS1 ESEV PDZ Binding Motif Associates with Dlg1 and Scribble To Disrupt Cellular Tight Junctions

(2011) L. Golebiewski et al.   JOURNAL OF VIROLOGY

Epigenetic Changes Mediated by MicroRNA miR29 Activate Cyclooxygenase 2 and Lambda-1 Interferon Production during Viral Infection

(2011) J. Fang et al.   JOURNAL OF VIROLOGY

Epigenetic Regulation of Learning and Memory by Drosophila EHMT/G9a

(2011) Jamie M. Kramer et al.   PLOS BIOLOGY

IL-32: A Host Proinflammatory Factor against Influenza Viral Replication Is Upregulated by Aberrant Epigenetic Modifications during Influenza A Virus Infection

(2010) W. Li et al.   JOURNAL OF IMMUNOLOGY

Epigenetic regulation of the alternatively activated macrophage phenotype

(2009) M. Ishii et al.   BLOOD

Activation of DNA Methyltransferase 1 by EBV Latent Membrane Protein 2A Leads to Promoter Hypermethylation of PTEN Gene in Gastric Carcinoma

(2009) R. Hino et al.   CANCER RESEARCH

Diverse Herpesvirus MicroRNAs Target the Stress-Induced Immune Ligand MICB to Escape Recognition by Natural Killer Cells

(2009) Daphna Nachmani et al.   Cell Host & Microbe

The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder

(2009) Roosmarijn C Drexhage et al.   Expert Review of Neurotherapeutics

SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-κB pathway in human monocyte macrophages in vitro

(2009) Susan F. Dosch et al.   VIRUS RESEARCH

Epstein-Barr Virus Latency in B Cells Leads to Epigenetic Repression and CpG Methylation of the Tumour Suppressor Gene Bim

(2009) Kostas Paschos et al.   PLoS Pathogens

KSHV LANA inhibits TGF-  signaling through epigenetic silencing of the TGF-  type II receptor

(2008) D. L. Di Bartolo et al.   BLOOD

Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A

(2008) Da-Li Zheng et al.   JOURNAL OF HEPATOLOGY

Temporal Dynamics of Cytomegalovirus Chromatin Assembly in Productively Infected Human Cells

(2008) A. Nitzsche et al.   JOURNAL OF VIROLOGY

Merkel cell polyomavirus encodes a microRNA with the ability to autoregulate viral gene expression

(2008) Gil Ju Seo et al.   VIROLOGY

The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53

(2008) Arnold J. Levine   VIROLOGY