Mesenchymal Stem Cell-Based Therapy for Stroke: Current Understanding and Challenges
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Title
Mesenchymal Stem Cell-Based Therapy for Stroke: Current Understanding and Challenges
Authors
Keywords
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Journal
Frontiers in Cellular Neuroscience
Volume 15, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-02-09
DOI
10.3389/fncel.2021.628940
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Note: Only part of the references are listed.- Bone Marrow-Derived NCS-01 Cells Advance a Novel Cell-Based Therapy for Stroke
- (2020) John Brown et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Autologous Mesenchymal Stem Cells Improve Motor Recovery in Subacute Ischemic Stroke: a Randomized Clinical Trial
- (2020) Assia Jaillard et al. Translational Stroke Research
- Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1
- (2020) Nancy Tseng et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress
- (2020) Xiaomo Wu et al. Stem Cell Research & Therapy
- Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases
- (2020) Deqiang Han et al. Stem Cells International
- Recent Advances in Cell-Based Therapies for Ischemic Stroke
- (2020) Satoshi Suda et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Impact of aging and comorbidities on ischemic stroke outcomes in preclinical animal models: A translational perspective
- (2020) Eduardo Candelario-Jalil et al. EXPERIMENTAL NEUROLOGY
- Exosomes derived from bone marrow mesenchymal stem cells harvested from type two diabetes rats promotes neurorestorative effects after stroke in type two diabetes rats
- (2020) Poornima Venkat et al. EXPERIMENTAL NEUROLOGY
- A Phase 2 Randomized, Sham-Controlled Trial of Internal Carotid Artery Infusion of Autologous Bone Marrow–Derived ALD-401 Cells in Patients With Recent Stable Ischemic Stroke (RECOVER-Stroke)
- (2019) Sean I. Savitz et al. CIRCULATION
- Combined Adipose Tissue-Derived Mesenchymal Stem Cell Therapy and Rehabilitation in Experimental Stroke
- (2019) Jingwei Mu et al. Frontiers in Neurology
- Mesenchymal Stem Cell-Derived Extracellular Vesicle Therapy for Stroke: Challenges and Progress
- (2019) Oh Young Bang et al. Frontiers in Neurology
- Endovascular Stroke Therapy
- (2019) Wade S. Smith Neurotherapeutics
- Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury
- (2019) Zheng Gang Zhang et al. Nature Reviews Neurology
- Aging and ischemic stroke
- (2019) Mohammed Yousufuddin et al. Aging-US
- Cell therapy for ischemic stroke: Are differences in preclinical and clinical study design responsible for the translational loss of efficacy?
- (2019) Li‐li Cui et al. ANNALS OF NEUROLOGY
- Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke
- (2019) Kaiming Liu et al. MICROVASCULAR RESEARCH
- Glia-Like Cells from Late-Passage Human MSCs Protect Against Ischemic Stroke Through IGFBP-4
- (2019) Jeong-Woo Son et al. MOLECULAR NEUROBIOLOGY
- Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
- (2019) Fernando Laso-García et al. Frontiers in Neurology
- Hypoxic preconditioning improves the survival and neural effects of transplanted mesenchymal stem cells via CXCL12/CXCR4 signalling in a rat model of cerebral infarction
- (2019) Yueqiang Hu et al. CELL BIOCHEMISTRY AND FUNCTION
- Intra-arterial stem cell therapy modulates neuronal calcineurin and confers neuroprotection after ischemic stroke
- (2019) Jackson Saraf et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Intravenous delivery of adipose tissue-derived mesenchymal stem cells improves brain repair in hyperglycemic stroke rats
- (2019) Mari Carmen Gómez-de Frutos et al. Stem Cell Research & Therapy
- Immunomodulation by Mesenchymal Stem Cells (MSCs): Mechanisms of Action of Living, Apoptotic, and Dead MSCs
- (2019) Andreas Robert Rudolf Weiss et al. Frontiers in Immunology
- Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment
- (2019) Yoda Yaghoubi et al. LIFE SCIENCES
- Preclinical translation of exosomes derived from mesenchymal stem/stromal cells
- (2019) Fanny M. Elahi et al. STEM CELLS
- Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis in vitro and in vivo: From biological characteristics to therapeutic mechanisms
- (2019) Fei Yin et al. World Journal of Stem Cells
- Efficacy of stem cell-based therapies for stroke
- (2019) Matthew R. Chrostek et al. BRAIN RESEARCH
- Human bone marrow mesenchymal stem cell-derived extracellular vesicles attenuate neuroinflammation evoked by focal brain injury in rats
- (2019) Sylwia Dabrowska et al. Journal of Neuroinflammation
- Two-year safety and clinical outcomes in chronic ischemic stroke patients after implantation of modified bone marrow–derived mesenchymal stem cells (SB623): a phase 1/2a study
- (2019) Gary K. Steinberg et al. JOURNAL OF NEUROSURGERY
- From the Lab to Patients: a Systematic Review and Meta-Analysis of Mesenchymal Stem Cell Therapy for Stroke
- (2019) Manoj M. Lalu et al. Translational Stroke Research
- Reperfusion therapy in acute ischemic stroke: dawn of a new era?
- (2018) Sonu Bhaskar et al. BMC Neurology
- Ethical and Safety Issues of Stem Cell-Based Therapy
- (2018) Vladislav Volarevic et al. International Journal of Medical Sciences
- The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke
- (2018) Catriona J Cunningham et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Immunomodulation By Therapeutic Mesenchymal Stromal Cells (MSC) Is Triggered Through Phagocytosis of MSC By Monocytic Cells
- (2018) Samantha F.H. de Witte et al. STEM CELLS
- Cell Therapy for Chronic Stroke
- (2018) Lawrence R. Wechsler et al. STROKE
- What Do Experimental Models Teach Us About Comorbidities in Stroke?
- (2018) Sunghee Cho et al. STROKE
- Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke: Clinical Outcomes from a Phase I Safety Study
- (2018) Daniel T. Laskowitz et al. Stem Cells Translational Medicine
- The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation
- (2018) Marilyn J Cipolla et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- The prevalence of Diabetes and its effects on Stroke Outcomes; a meta-analysis and literature review
- (2018) L H Lau et al. Journal of Diabetes Investigation
- Concise Review: Intercellular Communication Via Organelle Transfer in the Biology and Therapeutic Applications of Stem Cells
- (2018) Lisa M.A. Murray et al. STEM CELLS
- Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial
- (2018) Michael A Matthay et al. Lancet Respiratory Medicine
- Diabetic aggravation of stroke and animal models
- (2017) Ashish K. Rehni et al. EXPERIMENTAL NEUROLOGY
- Fabrication of Innovative Silk/Alginate Microcarriers for Mesenchymal Stem Cell Delivery and Tissue Regeneration
- (2017) Sara Perteghella et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Controlled clinical trials of cell therapy in stroke: Meta-analysis at six months after treatment
- (2017) Olivier Detante et al. International Journal of Stroke
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- (2017) Jane Ru Choi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial
- (2017) David C Hess et al. LANCET NEUROLOGY
- Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke
- (2017) Ling Wei et al. PROGRESS IN NEUROBIOLOGY
- Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms
- (2017) Connor Stonesifer et al. PROGRESS IN NEUROBIOLOGY
- Intrinsic Mesenchymal Stem Cell Dysfunction in Diabetes Mellitus: Implications for Autologous Cell Therapy
- (2017) Mari van de Vyver STEM CELLS AND DEVELOPMENT
- Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies
- (2017) Travis J. Block et al. Stem Cell Research & Therapy
- Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles
- (2017) Agnes T. Reiner et al. Stem Cells Translational Medicine
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- The safety of autologous and metabolically fit bone marrow mesenchymal stromal cells in medically refractory Crohn's disease - a phase 1 trial with three doses
- (2016) T. Dhere et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Intravenous Injection of Clinical Grade Human MSCs after Experimental Stroke: Functional Benefit and Microvascular Effect
- (2016) Anaïck Moisan et al. CELL TRANSPLANTATION
- Clinical Trials with Mesenchymal Stem Cells: An Update
- (2016) Tiziana Squillaro et al. CELL TRANSPLANTATION
- Effect of Extracellular Vesicles on Neural Functional Recovery and Immunologic Suppression after Rat Cerebral Apoplexy
- (2016) Beilei Hu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis
- (2016) Jeffrey L. Saver et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Bone marrow mesenchymal stem cell therapy in ischemic stroke: mechanisms of action and treatment optimization strategies
- (2016) Gui-hong Li et al. Neural Regeneration Research
- Clinical Outcomes of Transplanted Modified Bone Marrow–Derived Mesenchymal Stem Cells in Stroke
- (2016) Gary K. Steinberg et al. STROKE
- miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats
- (2016) Chengcheng Cui et al. Stem Cells Translational Medicine
- Recent Advances in Stem Cell-Based Therapeutics for Stroke
- (2016) Eleonora Napoli et al. Translational Stroke Research
- Increasing Dose of Autologous Bone Marrow Mononuclear Cells Transplantation Is Related to Stroke Outcome: Results from a Pooled Analysis of Two Clinical Trials
- (2016) Francisco Moniche et al. Stem Cells International
- Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis
- (2016) Aleksandra Klimczak et al. Stem Cells International
- Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue
- (2015) JUNE SEOK HEO et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury
- (2015) Yanlu Zhang et al. JOURNAL OF NEUROSURGERY
- Bone marrow-derived mesenchymal stem cells rescue injured H9c2 cells via transferring intact mitochondria through tunneling nanotubes in an in vitro simulated ischemia/reperfusion model
- (2015) HUI HAN et al. Molecular Medicine Reports
- A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
- (2015) Olvert A. Berkhemer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mesenchymal Stem Cells: A Friend or Foe in Immune-Mediated Diseases
- (2015) Marina Gazdic et al. Stem Cell Reviews and Reports
- 2015 American Heart Association/American Stroke Association Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment
- (2015) William J. Powers et al. STROKE
- The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy
- (2015) Jun Zhang et al. Stem Cell Research & Therapy
- Improving the Post-Stroke Therapeutic Potency of Mesenchymal Multipotent Stromal Cells by Cocultivation With Cortical Neurons: The Role of Crosstalk Between Cells
- (2015) Valentina A. Babenko et al. Stem Cells Translational Medicine
- Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression
- (2015) Thorsten R. Doeppner et al. Stem Cells Translational Medicine
- Mesenchymal Stem Cells: A Friend or Foe in Immune-Mediated Diseases
- (2015) Marina Gazdic et al. Stem Cell Reviews and Reports
- Intra-Arterial Transplantation of Allogeneic Mesenchymal Stem Cells Mounts Neuroprotective Effects in a Transient Ischemic Stroke Model in Rats: Analyses of Therapeutic Time Window and Its Mechanisms
- (2015) Atsuhiko Toyoshima et al. PLoS One
- Mitochondrial Transfer of Induced Pluripotent Stem Cell–Derived Mesenchymal Stem Cells to Airway Epithelial Cells Attenuates Cigarette Smoke–Induced Damage
- (2014) Xiang Li et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Mouse bone marrow-derived mesenchymal stem cells induce macrophage M2 polarization through the nuclear factor-κB and signal transducer and activator of transcription 3 pathways
- (2014) Shuo Gao et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Sex differences in stroke: The contribution of coagulation
- (2014) Meaghan Roy-O'Reilly et al. EXPERIMENTAL NEUROLOGY
- Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model
- (2014) Michele Longoni Calió et al. FREE RADICAL BIOLOGY AND MEDICINE
- Neurogenesis and Inflammation after Ischemic Stroke: What is Known and Where We Go from Here
- (2014) Matthew K Tobin et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Reparative Therapy for Acute Ischemic Stroke with Allogeneic Mesenchymal Stem Cells from Adipose Tissue: A Safety Assessment
- (2014) Exuperio Díez-Tejedor et al. Journal of Stroke & Cerebrovascular Diseases
- Meta-analysis of preclinical studies of mesenchymal stromal cells for ischemic stroke
- (2014) Q. Vu et al. NEUROLOGY
- The Need for Randomization in Animal Trials: An Overview of Systematic Reviews
- (2014) Jennifer A. Hirst et al. PLoS One
- An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
- (2014) H. Clevers et al. SCIENCE
- Stem Cell-Based Therapies for Ischemic Stroke
- (2014) Lei Hao et al. Biomed Research International
- Paracrine Mechanisms of Mesenchymal Stem Cell-Based Therapy: Current Status and Perspectives
- (2013) Xiaoting Liang et al. CELL TRANSPLANTATION
- Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats
- (2013) Hongqi Xin et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Stroke-prone renovascular hypertensive rat as an animal model for stroke studies: From artery to brain
- (2013) Song-Jie Liao et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles
- (2013) Hongqi Xin et al. STEM CELLS
- Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke
- (2013) María Gutiérrez-Fernández et al. Stem Cell Research & Therapy
- Towards whole-body imaging at the single cell level using ultra-sensitive stem cell labeling with oligo-arginine modified upconversion nanoparticles
- (2012) Chao Wang et al. BIOMATERIALS
- Bone marrow stromal cells enhance the angiogenesis in ischaemic cortex after stroke: involvement of notch signalling
- (2012) Fei Guo et al. CELL BIOLOGY INTERNATIONAL
- Glibenclamide Enhances Neurogenesis and Improves Long-Term Functional Recovery after Transient Focal Cerebral Ischemia
- (2012) Francisco J Ortega et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury
- (2012) Mohammad Naimul Islam et al. NATURE MEDICINE
- Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells
- (2012) Marius Strioga et al. STEM CELLS AND DEVELOPMENT
- How mesenchymal stem cells interact with tissue immune responses
- (2012) Yufang Shi et al. TRENDS IN IMMUNOLOGY
- Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke
- (2011) O. Honmou et al. BRAIN
- Human stem cell research and regenerative medicine--present and future
- (2011) V. Volarevic et al. BRITISH MEDICAL BULLETIN
- Mesenchymal Stem Cells
- (2011) Adam R. Williams et al. CIRCULATION RESEARCH
- Safety of Intravenous Infusion of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Animals and Humans
- (2011) Jeong Chan Ra et al. STEM CELLS AND DEVELOPMENT
- Adverse Effects of Bone Marrow Stromal Cell Treatment of Stroke in Diabetic Rats
- (2011) Jieli Chen et al. STROKE
- Role of the EGFR ligand/receptor system in the secretion of angiogenic factors in mesenchymal stem cells
- (2010) Antonella De Luca et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Different Strokes for Different Folks: The Rich Diversity of Animal Models of Focal Cerebral Ischemia
- (2010) David W Howells et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- A Long-Term Follow-Up Study of Intravenous Autologous Mesenchymal Stem Cell Transplantation in Patients With Ischemic Stroke
- (2010) Jin Soo Lee et al. STEM CELLS
- Transplantation of placenta-derived mesenchymal stromal cells upon experimental stroke in rats
- (2009) Alexander Kranz et al. BRAIN RESEARCH
- Cell Therapy for Age-Related Disorders: Myocardial Infarction and Stroke – A Mini-Review
- (2008) Brent A. Williams et al. GERONTOLOGY
- Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
- (2008) Werner Hacke et al. NEW ENGLAND JOURNAL OF MEDICINE
- Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process
- (2008) Wolfgang Wagner et al. PLoS One
- Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality
- (2008) Malcolm R. Macleod et al. STROKE
- Dual-Modality Monitoring of Targeted Intraarterial Delivery of Mesenchymal Stem Cells After Transient Ischemia
- (2008) Piotr Walczak et al. STROKE
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