Mesenchymal Stem Cells: A Friend or Foe in Immune-Mediated Diseases

Mesenchymal stem cells suppress CD8+T cell-mediated activation by suppressing natural killer group 2, member D protein receptor expression and secretion of prostaglandin E2, indoleamine 2, 3-dioxygenase and transforming growth factor-β

(2014) Mingfen Li et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interferon-Gamma Modification of Mesenchymal Stem Cells: Implications of Autologous and Allogeneic Mesenchymal Stem Cell Therapy in Allotransplantation

(2014) Kisha Nandini Sivanathan et al.   Stem Cell Reviews and Reports

Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation

(2013) Maria Ester Bernardo et al.   Cell Stem Cell

Stem Cell-Based Therapy for Spinal Cord Injury

(2013) Vladislav Volarevic et al.   CELL TRANSPLANTATION

Multipotent stromal cells skew monocytes towards an anti-inflammatory interleukin-10-producing phenotype by production of interleukin-6

(2013) S. M. Melief et al.   HAEMATOLOGICA

Novel Mechanism of Inhibition of Dendritic Cells Maturation by Mesenchymal Stem Cells via Interleukin-10 and the JAK1/STAT3 Signaling Pathway

(2013) Wen-hua Liu et al.   PLoS One

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages

(2013) Sara M. Melief et al.   STEM CELLS

Concise review: Adult mesenchymal stromal cell therapy for inflammatory diseases: How well are we joining the dots?

(2013) Matthew D. Griffin et al.   STEM CELLS

Concise Review: Two negative feedback loops place mesenchymal stem/stromal cells at the center of early regulators of inflammation

(2013) Darwin J. Prockop   STEM CELLS

Mesenchymal stem cells: a double-edged sword in regulating immune responses

(2012) W Li et al.   CELL DEATH AND DIFFERENTIATION

Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction

(2012) Beatrice Del Papa et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mesenchymal Stromal Cells Improve Survival During Sepsis in the Absence of Heme Oxygenase-1: The Importance of Neutrophils

(2012) Sean R. R. Hall et al.   STEM CELLS

Mesenchymal stem cells and autoimmune diseases

(2011) Francesco Dazzi et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF- B signaling in resident macrophages

(2011) H. Choi et al.   BLOOD

Human stem cell research and regenerative medicine--present and future

(2011) V. Volarevic et al.   BRITISH MEDICAL BULLETIN

Mesenchymal stem cell inhibition of T-helper 17 cell- differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor

(2011) Michelle M. Duffy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

Human MSC Suppression Correlates With Cytokine Induction of Indoleamine 2,3-Dioxygenase and Bystander M2 Macrophage Differentiation

(2011) Moïra François et al.   MOLECULAR THERAPY

Exploring the Role of Soluble Factors Associated with Immune Regulatory Properties of Mesenchymal Stem Cells

(2011) Ênio José Bassi et al.   Stem Cell Reviews and Reports

Toll-Like Receptor-3-Activated Human Mesenchymal Stromal Cells Significantly Prolong the Survival and Function of Neutrophils

(2011) Marco A. Cassatella et al.   STEM CELLS

The immunomodulatory capacity of mesenchymal stem cells

(2011) Antje Gebler et al.   TRENDS IN MOLECULAR MEDICINE

Mesenchymal stem cell effects on T-cell effector pathways

(2011) Michelle M Duffy et al.   Stem Cell Research & Therapy

Interleukin-1 receptor antagonist (IL-1Ra) and IL-1Ra producing mesenchymal stem cells as modulators of diabetogenesis

(2010) Vladislav Volarevic et al.   AUTOIMMUNITY

Mesenchymal Stem Cells Inhibit Human Th17 Cell Differentiation and Function and Induce a T Regulatory Cell Phenotype

(2010) S. Ghannam et al.   JOURNAL OF IMMUNOLOGY

Tissue-resident mesenchymal stem cells attract peripheral blood neutrophils and enhance their inflammatory activity in response to microbial challenge

(2010) Sven Brandau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype

(2010) Ruth S. Waterman et al.   PLoS One

Evidence for the Involvement of Galectin-3 in Mesenchymal Stem Cell Suppression of Allogeneic T-Cell Proliferation

(2010) M. Sioud et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Epithelial-Mesenchymal Transition-Derived Cells Exhibit Multilineage Differentiation Potential Similar to Mesenchymal Stem Cells

(2010) Venkata Lokesh Battula et al.   STEM CELLS

Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications

(2010) Soufiane Ghannam et al.   Stem Cell Research & Therapy

MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2

(2009) G. M. Spaggiari et al.   BLOOD

Cell contact, prostaglandin E2and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25Highforkhead box P3+regulatory T cells

(2009) K. English et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression

(2009) Guangwen Ren et al.   STEM CELLS

Galectin-1 and Semaphorin-3A Are Two Soluble Factors Conferring T-Cell Immunosuppression to Bone Marrow Mesenchymal Stem Cell

(2009) Yves Lepelletier et al.   STEM CELLS AND DEVELOPMENT

Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction

(2008) M. Rafei et al.   BLOOD

How Do Mesenchymal Stromal Cells Suppress T Cells?

(2008) Armand Keating   Cell Stem Cell

Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide

(2008) Guangwen Ren et al.   Cell Stem Cell

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Leukemia inhibitory factor: Role in human mesenchymal stem cells mediated immunosuppression

(2008) Aisha Nasef et al.   CELLULAR IMMUNOLOGY

The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes

(2008) S. Tabera et al.   HAEMATOLOGICA

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

(2008) Krisztián Németh et al.   NATURE MEDICINE

Reciprocal Interactions Between Human Mesenchymal Stem Cells and γδ T Cells Or Invariant Natural Killer T Cells

(2008) Ignazia Prigione et al.   STEM CELLS

Bone Marrow-Derived Mesenchymal Stem Cells Induce Both Polyclonal Expansion and Differentiation of B Cells Isolated from Healthy Donors and Systemic Lupus Erythematosus Patients

(2007) Elisabetta Traggiai et al.   STEM CELLS

Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+Regulatory T Cells

(2007) Zohair Selmani et al.   STEM CELLS

Human Mesenchymal Stem Cells Inhibit Neutrophil Apoptosis: A Model for Neutrophil Preservation in the Bone Marrow Niche

(2007) Lizzia Raffaghello et al.   STEM CELLS