Polyploidy formation in cancer cells: how a Trojan horse is born

Polyploidy in Cardiomyocytes

(2020) Wouter Derks et al.   CIRCULATION RESEARCH

Studies of Non-Protective Autophagy Provide Evidence that Recovery from Therapy-Induced Senescence is Independent of Early Autophagy

(2020) Tareq Saleh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitotic slippage is determined by p31comet and the weakening of the spindle-assembly checkpoint

(2020) Tsun Ming Lok et al.   ONCOGENE

BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis

(2020) Jasdeep Mann et al.   Scientific Reports

Tamoxifen is a candidate first‐in‐class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells—Unrecognized players in tumorigenesis

(2020) Shai White‐Gilbertson et al.   Cancer Medicine

“Mitotic Slippage” and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres

(2020) Kristine Salmina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells

(2020) Agnieszka Bojko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Paradoxes of cancer: Survival at the brink

(2020) Jekaterina Erenpreisa et al.   SEMINARS IN CANCER BIOLOGY

Polyploidy and the mitosis path to epidermal cell fate

(2019) Alberto Gandarillas et al.   CELL CYCLE

The Cancer Aneuploidy Paradox: In the Light of Evolution

(2019) Kristine Salmina et al.   Genes

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy

(2019) Tian Tian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of heterogeneous environment and docetaxel gradient in the emergence of polyploid, mesenchymal and resistant prostate cancer cells

(2019) Ke-Chih Lin et al.   CLINICAL & EXPERIMENTAL METASTASIS

A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade

(2019) Xiaoxia Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Context is everything: aneuploidy in cancer

(2019) Uri Ben-David et al.   NATURE REVIEWS GENETICS

Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers

(2019) Ahmed Gomaa et al.   Scientific Reports

Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models

(2019) Tony Yeung et al.   Oncotarget

The Benzimidazole-Based Anthelmintic Parbendazole: A Repurposed Drug Candidate That Synergizes with Gemcitabine in Pancreatic Cancer

(2019) Rosalba Florio et al.   Cancers

Prostatic Adenocarcinoma With Focal Pleomorphic Giant Cell Features

(2018) Abdullah M. Alharbi et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity

(2018) David Díaz-Carballo et al.   CANCER RESEARCH

Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line

(2018) Małgorzata Milczarek et al.   FOOD AND CHEMICAL TOXICOLOGY

Dexamethasone alleviates pemetrexed-induced senescence in Non-Small-Cell Lung Cancer

(2018) Haiyan Ge et al.   FOOD AND CHEMICAL TOXICOLOGY

The impact of mitotic errors on cell proliferation and tumorigenesis

(2018) Michelle S. Levine et al.   GENES & DEVELOPMENT

Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo

(2018) Aditya Parekh et al.   ONCOGENE

Protective Effects of Fullerene C60 Nanoparticles and Virgin Olive Oil against Genotoxicity Induced by Cyclophosphamide in Rats

(2018) Fayza M. Aly et al.   Oxidative Medicine and Cellular Longevity

The Dualistic Origin of Human Tumors

(2018) Jinsong Liu   SEMINARS IN CANCER BIOLOGY

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer

(2018) Ryosuke Tanino et al.   Oncotarget

Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

(2018) Bela Ozsvari et al.   Aging-US

Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution

(2018) Ana C. Henriques et al.   CANCER LETTERS

Environmental stresses induce karyotypic instability in colorectal cancer cells

(2018) Zhihao Tan et al.   MOLECULAR BIOLOGY OF THE CELL

Solving the Polyploid Mystery in Health and Disease

(2018) K.J. Gjelsvik et al.   TRENDS IN GENETICS

Consequences of mitotic slippage for antimicrotubule drug therapy

(2017) Bing Cheng et al.   ENDOCRINE-RELATED CANCER

Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase II mouse oocyte quality

(2017) Roohi Jeelani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting therapy-resistant cancer stem cells by hyperthermia

(2017) A. L. Oei et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Multinucleated Giant Cancer Cells Produced in Response to Ionizing Radiation Retain Viability and Replicate Their Genome

(2017) Razmik Mirzayans et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vinblastine and antihelmintic mebendazole potentiate temozolomide in resistant gliomas

(2017) Franciele Cristina Kipper et al.   INVESTIGATIONAL NEW DRUGS

The evolutionary significance of polyploidy

(2017) Yves Van de Peer et al.   NATURE REVIEWS GENETICS

PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma

(2017) V Colicchia et al.   ONCOGENE

Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells

(2017) N Niu et al.   ONCOGENE

Entosis Is Induced by Glucose Starvation

(2017) Jens C. Hamann et al.   Cell Reports

Mitosis can drive cell cannibalism through entosis

(2017) Joanne Durgan et al.   eLife

Enhanced efficacy of 5-fluorouracil in combination with a dual histone deacetylase and phosphatidylinositide 3-kinase inhibitor (CUDC-907) in colorectal cancer cells

(2017) NehadM Alajez et al.   Saudi Journal of Gastroenterology

Squamous Cell Cancers: A Unified Perspective on Biology and Genetics

(2016) G. Paolo Dotto et al.   CANCER CELL

Dual Chromatin and Cytoskeletal Remodeling by SETD2

(2016) In Young Park et al.   CELL

Disentangling the aneuploidy and senescence paradoxes: a study of triploid breast cancers non-responsive to neoadjuvant therapy

(2016) B. I. Gerashchenko et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Antiproliferative Fate of the Tetraploid Formed after Mitotic Slippage and Its Promotion; A Novel Target for Cancer Therapy Based on Microtubule Poisons

(2016) Yuji Nakayama et al.   MOLECULES

Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice

(2016) Halina Was et al.   Oncotarget

Linking genomic reorganization to tumor initiation via the giant cell cycle

(2016) N Niu et al.   Oncogenesis

Wound-Induced Polyploidy Is Required for Tissue Repair

(2016) Vicki P. Losick   Advances in Wound Care

Solar ultraviolet radiation: properties, characteristics and amounts observed in Brazil and South America

(2015) Marcelo de Paula Corrêa   ANAIS BRASILEIROS DE DERMATOLOGIA

Radiation-induced homotypic cell fusions of innately resistant glioblastoma cells mediate their sustained survival and recurrence

(2015) E. Kaur et al.   CARCINOGENESIS

Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide

(2015) Anda Huna et al.   CELL CYCLE

Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication

(2015) C. I. Swanson et al.   DEVELOPMENT

The number of polyploid giant cancer cells and epithelial-mesenchymal transition-related proteins are associated with invasion and metastasis in human breast cancer

(2015) Fei Fei et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression

(2015) David Kozono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all

(2015) Arlene L. Oei et al.   Radiation Oncology

A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype

(2015) Verena Rohnalter et al.   Oncotarget

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

(2015) Grazyna Mosieniak et al.   NEOPLASIA

Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1

(2015) Barbara Jonchère et al.   Oncotarget

Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe

(2015) Elodie A. Pérès et al.   Oncotarget

Polyploid Formation Shapes Flowering Plant Diversity

(2014) Samuel V. Scarpino et al.   AMERICAN NATURALIST

Polyploid giant cancer cells with budding and the expression of cyclin E, S-phase kinase-associated protein 2, stathmin associated with the grading and metastasis in serous ovarian tumor

(2014) Hongcheng Lv et al.   BMC CANCER

Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers

(2014) Zhanna V Chitikova et al.   CELL CYCLE

Oral cancer/endothelial cell fusion experiences nuclear fusion and acquisition of enhanced survival potential

(2014) Kai Song et al.   EXPERIMENTAL CELL RESEARCH

Smokeless tobacco increases aneuploidy in oral HPV16 E6/E7-transformed keratinocytesin vitro

(2014) Marina Merne et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Survivin safeguards chromosome numbers and protects from aneuploidy independently from p53

(2014) Ralf Wiedemuth et al.   Molecular Cancer

Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics

(2014) Sharad Sharma et al.   Molecular Oncology

Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma

(2014) Carolyn S Lee et al.   NATURE GENETICS

EMT and Acquisition of Stem Cell-Like Properties Are Involved in Spontaneous Formation of Tumorigenic Hybrids between Lung Cancer and Bone Marrow-Derived Mesenchymal Stem Cells

(2014) Mei-Hua Xu et al.   PLoS One

CoCl2, a Mimic of Hypoxia, Induces Formation of Polyploid Giant Cells with Stem Characteristics in Colon Cancer

(2014) Laura M. Lopez-Sánchez et al.   PLoS One

Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention

(2014) D. Lissa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer

(2014) Jermaine Coward et al.   Frontiers in Oncology

Sperm-Associated Antigen 4, a Novel Hypoxia-Inducible Factor 1 Target, Regulates Cytokinesis, and Its Expression Correlates with the Prognosis of Renal Cell Carcinoma

(2013) Kumi Shoji et al.   AMERICAN JOURNAL OF PATHOLOGY

Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal

(2013) Jekaterina Erenpreisa et al.   Cancer Cell International

Generation of erythroid cells from fibroblasts and cancer cells in vitro and in vivo

(2013) Shiwu Zhang et al.   CANCER LETTERS

ERCC1 function in nuclear excision and interstrand crosslink repair pathways is mediated exclusively by the ERCC1-202 isoform

(2013) Luc Friboulet et al.   CELL CYCLE

DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells

(2013) Thomas R. Jackson et al.   CELL CYCLE

Immortality of cancers

(2013) Peter Duesberg et al.   CELL CYCLE

Mitosis and apoptosis: how is the balance set?

(2013) Caroline H Topham et al.   CURRENT OPINION IN CELL BIOLOGY

Tissue Repair through Cell Competition and Compensatory Cellular Hypertrophy in Postmitotic Epithelia

(2013) Yoichiro Tamori et al.   DEVELOPMENTAL CELL

Radiation-induced mitotic cell death and glioblastoma radioresistance: A new regulating pathway controlled by integrin-linked kinase, hypoxia-inducible factor 1alpha and survivin in U87 cells

(2013) Olivia Lanvin et al.   EUROPEAN JOURNAL OF CANCER

Hyperthermia versus Oncothermia: Cellular Effects in Complementary Cancer Therapy

(2013) Gabriella Hegyi et al.   Evidence-based Complementary and Alternative Medicine

Synergistic effect of hydrogen peroxide on polyploidization during the megakaryocytic differentiation of K562 leukemia cells by PMA

(2013) Yoshihiro Ojima et al.   EXPERIMENTAL CELL RESEARCH

Number of glioma polyploid giant cancer cells (PGCCs) associated with vasculogenic mimicry formation and tumor grade in human glioma

(2013) Yang Qu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of mTOR Pathway Sensitizes Acute Myeloid Leukemia Cells to Aurora Inhibitors by Suppression of Glycolytic Metabolism

(2013) L.-L. Liu et al.   MOLECULAR CANCER RESEARCH

Hypoxia regulates the sperm associated antigen 4 (SPAG4) via HIF, which is expressed in renal clear cell carcinoma and promotes migration and invasion in vitro

(2013) Karl Xaver Knaup et al.   MOLECULAR CARCINOGENESIS

Volume increase and spatial shifts of chromosome territories in nuclei of radiation-induced polyploidizing tumour cells

(2013) Jutta Schwarz-Finsterle et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Generation of cancer stem-like cells through the formation of polyploid giant cancer cells

(2013) S Zhang et al.   ONCOGENE

iTRAQ-Based Proteomic Analysis of Polyploid Giant Cancer Cells and Budding Progeny Cells Reveals Several Distinct Pathways for Ovarian Cancer Development

(2013) Shiwu Zhang et al.   PLoS One

Histopathology and cytotoxicity as biomarkers in treated rats with cadmium and some therapeutic agents

(2013) Amal I. El-Refaiy et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Telomere-Driven Tetraploidization Occurs in Human Cells Undergoing Crisis and Promotes Transformation of Mouse Cells

(2012) Teresa Davoli et al.   CANCER CELL

Mechanisms of Ploidy Increase in Human Cancers: A New Role for Cell Cannibalism

(2012) M. Krajcovic et al.   CANCER RESEARCH

Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence

(2012) Elise McKenna et al.   CELL CYCLE

Endoreplication and polyploidy: insights into development and disease

(2012) D. T. Fox et al.   DEVELOPMENT

Polyploidy road to therapy-induced cellular senescence and escape

(2012) Qin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular control of animal cell cytokinesis

(2012) Juan Pablo Fededa et al.   NATURE CELL BIOLOGY

Production of Diploid Male Gametes in Arabidopsis by Cold-Induced Destabilization of Postmeiotic Radial Microtubule Arrays

(2012) N. De Storme et al.   PLANT PHYSIOLOGY

Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles

(2012) RUTH MAGAYE et al.   Experimental and Therapeutic Medicine

Epigenomics in cancer management

(2012) Fabricio Costa   Cancer Management and Research

Polyploid tumour cells elicit paradiploid progeny through depolyploidizing divisions and regulated autophagic degradation

(2011) Jekaterina Erenpreisa et al.   CELL BIOLOGY INTERNATIONAL

Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5

(2011) Santiago Rello-Varona et al.   CELL CYCLE

Substrate-specific regulation of ubiquitination by the anaphase-promoting complex

(2011) Ling Song et al.   CELL CYCLE

Yeast cell morphology and sexual reproduction – A short overview and some considerations

(2011) Michael Knop   COMPTES RENDUS BIOLOGIES

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tumorigenic polyploid cells contain elevated ROS and ARE selectively targeted by antioxidant treatment

(2011) Meejeon Roh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Does formaldehyde induce aneuploidy?

(2011) G. Speit et al.   MUTAGENESIS

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

A non-genetic route to aneuploidy in human cancers

(2011) Matej Krajcovic et al.   NATURE CELL BIOLOGY

RNA interference targeting survivin exerts antitumoral effects in vitro and in established glioma xenografts in vivo

(2011) S. Hendruschk et al.   NEURO-ONCOLOGY

Epigenetic diet: impact on the epigenome and cancer

(2011) Tabitha M Hardy et al.   Epigenomics

Hazardous Compounds in Tobacco Smoke

(2011) Reinskje Talhout et al.   International Journal of Environmental Research and Public Health

Evolution of Tumor Metabolism might Reflect Carcinogenesis as a Reverse Evolution process (Dismantling of Multicellularity)

(2011) Khalid O. Alfarouk et al.   Cancers

Epigenetic Effects and Molecular Mechanisms of Tumorigenesis Induced by Cigarette Smoke: An Overview

(2011) Rong-Jane Chen et al.   Journal of Oncology

Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints

(2010) Michal Sabisz et al.   BIOCHEMICAL PHARMACOLOGY

Aneuploidy as an early mechanistic event in metal carcinogenesis

(2010) Sandra S. Wise et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy

(2010) Teresa Davoli et al.   CELL

Cytokinesis and cancer

(2010) Antonia P. Sagona et al.   FEBS LETTERS

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Mad2 inhibits the mitotic kinesin MKlp2

(2010) Sang Hyun Lee et al.   JOURNAL OF CELL BIOLOGY

p53-Dependent Induction of Prostate Cancer Cell Senescence by the PIM1 Protein Kinase

(2010) M. Zemskova et al.   MOLECULAR CANCER RESEARCH

DNA copy number loss and allelic imbalance at 2p16 in lung cancer associated with asbestos exposure

(2009) E Kettunen et al.   BRITISH JOURNAL OF CANCER

Targeting Heat Shock Protein 90 Overrides the Resistance of Lung Cancer Cells by Blocking Radiation-Induced Stabilization of Hypoxia-Inducible Factor-1α

(2009) Woo-Young Kim et al.   CANCER RESEARCH

Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization

(2009) Patrick Steigemann et al.   CELL

The role of meiotic cohesin REC8 in chromosome segregation in γ irradiation-induced endopolyploid tumour cells

(2009) Jekaterina Erenpreisa et al.   EXPERIMENTAL CELL RESEARCH

Endoreplication: polyploidy with purpose

(2009) H. O. Lee et al.   GENES & DEVELOPMENT

The role of aneuploidy in promoting and suppressing tumors: Figure 1.

(2009) Beth A.A. Weaver et al.   JOURNAL OF CELL BIOLOGY

9-bromonoscapine-induced mitotic arrest of cigarette smoke condensate-transformed breast epithelial cells

(2009) Aruna S. Jaiswal et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis

(2009) S. Peddibhotla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endopolyploidy in irradiated p53-deficient tumour cell lines: Persistence of cell division activity in giant cells expressing Aurora-B kinase

(2008) Jekaterina Erenpreisa et al.   CELL BIOLOGY INTERNATIONAL

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

(2008) Pierre-Emmanuel Puig et al.   CELL BIOLOGY INTERNATIONAL

Endocycling cells do not apoptose in response to DNA rereplication genotoxic stress

(2008) S. Mehrotra et al.   GENES & DEVELOPMENT

The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles

(2008) N. Zielke et al.   GENES & DEVELOPMENT

Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells

(2008) Malgorzata A. Sliwinska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The cell biology of cell-in-cell structures

(2008) Michael Overholtzer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY