Sustained high expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells

NRF2-driven redox metabolism takes center stage in cancer metabolism from an outside-in perspective

(2020) Eun-Ji Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Potential Applications of NRF2 Modulators in Cancer Therapy

(2020) Emiliano Panieri et al.   Antioxidants

Arsenite induces testicular oxidative stress in vivo and in vitro leading to ferroptosis

(2020) Pan Meng et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis

(2020) Sen Wei et al.   ENVIRONMENTAL RESEARCH

Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes

(2020) Jing Wu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway

(2019) Zhi-li Jia et al.   CHEMOSPHERE

High NF-E2-related factor 2 expression predicts poor prognosis in patients with lung cancer: a meta-analysis of cohort studies

(2019) Qianlei Yang et al.   FREE RADICAL RESEARCH

Aucubin, a natural iridoid glucoside, attenuates oxidative stress-induced testis injury by inhibiting JNK and CHOP activation via Nrf2 up-regulation

(2019) Bo Ma et al.   PHYTOMEDICINE

Thioarsenite Detection and Implications for Arsenic Transport in Groundwater

(2019) Richard T. Wilkin et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Role of mitochondrial DNA in oxidative damage induced by sodium arsenite in human bronchial epithelial cells

(2019) Jing Wu et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes

(2019) Xiafang Wu et al.   Oxidative Medicine and Cellular Longevity

Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway

(2019) Sen Wei et al.   JOURNAL OF HAZARDOUS MATERIALS

Enhanced glycometabolism as a mechanism of NQO1 potentiated growth of NSCLC revealed by metabolomic profiling

(2018) Xuefang Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

NRF2 addiction in cancer cells

(2018) Hiroshi Kitamura et al.   CANCER SCIENCE

Ferroptosis is newly characterized form of neuronal cell death in response to arsenite exposure

(2018) Qianghu Tang et al.   NEUROTOXICOLOGY

N 6 -methyladenosine mediates the cellular proliferation and apoptosis via microRNAs in arsenite-transformed cells

(2018) Shiyan Gu et al.   TOXICOLOGY LETTERS

Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control

(2018) Shuya Kasai et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer

(2017) Shasha Tao et al.   MOLECULAR CARCINOGENESIS

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses

(2017) L Torrente et al.   ONCOGENE

Downregulation of NAD(P)H:quinone oxidoreductase 1 inhibits proliferation, cell cycle and migration of cholangiocarcinoma cells

(2017) Siriwoot Butsri et al.   Oncology Letters

Dual-negative expression of Nrf2 and NQO1 predicts superior outcomes in patients with non-small cell lung cancer

(2017) Ying-Hui Tong et al.   Oncotarget

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer

(2017) Elsa B Krall et al.   eLife

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

(2017) Michael John Kerins et al.   ANTIOXIDANTS & REDOX SIGNALING

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction

(2016) Chao Zhang et al.   Oncotarget

Clinicopathological significance of nuclear factor (erythroid-2)-related factor 2 (Nrf2) expression in gastric cancer

(2015) Yota Kawasaki et al.   BMC CANCER

High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma

(2015) Xuelian Cui et al.   BMC CANCER

Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma

(2015) Mingxin Zhang et al.   BMC CANCER

Hypermethylation of the Keap1 gene inactivates its function, promotes Nrf2 nuclear accumulation, and is involved in arsenite-induced human keratinocyte transformation

(2015) Dapeng Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dual roles of NRF2 in tumor prevention and progression: Possible implications in cancer treatment

(2015) Eui Jung Moon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells

(2015) Xu Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

Mutant p53 confers chemoresistance in non-small cell lung cancer by upregulating Nrf2

(2015) Min-Che Tung et al.   Oncotarget

NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix

(2014) Yue Ma et al.   BMC CANCER

Old, new and emerging functions of caspases

(2014) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

Significance of NQO1 overexpression for prognostic evaluation of gastric adenocarcinoma

(2014) Lijuan Lin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Clinical implications of high NQO1 expression in breast cancers

(2014) Yang Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

NAD(P)H:quinone oxidoreductase-1 overexpression predicts poor prognosis in small cell lung cancer

(2014) XUELIAN CUI et al.   ONCOLOGY REPORTS

Groundwater Arsenic Contamination Throughout China

(2013) L. Rodriguez-Lado et al.   SCIENCE

High arsenic in rice is associated with elevated genotoxic effects in humans

(2013) Mayukh Banerjee et al.   Scientific Reports

Public Health Responses to Arsenic in Rice and Other Foods

(2013) Ana Navas-Acien et al.   JAMA Internal Medicine

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance

(2012) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis

(2012) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

(2012) Yosuke Hirotsu et al.   NUCLEIC ACIDS RESEARCH

NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones

(2011) David Siegel et al.   BIOCHEMICAL PHARMACOLOGY

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

(2011) P. A. Konstantinopoulos et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The cell cycle and cancer

(2011) Gareth H Williams et al.   JOURNAL OF PATHOLOGY

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

(2010) Nicole F. Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

(2010) Albena T. Dinkova-Kostova et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

(2009) S. Homma et al.   CLINICAL CANCER RESEARCH

Biological Responses to Arsenic Compounds

(2009) Leonidas C. Platanias   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

(2008) T. Ohta et al.   CANCER RESEARCH

Arsenic-induced malignant transformation of human keratinocytes: Involvement of Nrf2

(2008) Jingbo Pi et al.   FREE RADICAL BIOLOGY AND MEDICINE