Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential

Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice

(2021) Nga T. Nguyen et al.   ARCHIVES OF TOXICOLOGY

A mitochondrial journey through acetaminophen hepatotoxicity

(2020) Anup Ramachandran et al.   FOOD AND CHEMICAL TOXICOLOGY

Mitochondrial depolarization and repolarization in the early stages of acetaminophen hepatotoxicity in mice

(2020) Kenneth W. Dunn et al.   TOXICOLOGY

Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen

(2020) Gary Eichenbaum et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A critical review of the acetaminophen preclinical carcinogenicity and tumor promotion data and their implications for its carcinogenic hazard potential

(2020) Jay Murray et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

An Integrated Approach Using Publicly Available Resources for Identifying and Characterizing Chemicals of Potential Toxicity Concern: Proof-of-Concept with Chemicals That Affect Cancer Pathways

(2019) Shoba Iyer et al.   TOXICOLOGICAL SCIENCES

Delayed Treatment with 4-Methylpyrazole Protects against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun N-Terminal Kinase

(2019) Jephte Y Akakpo et al.   TOXICOLOGICAL SCIENCES

The role of apoptosis in acetaminophen hepatotoxicity

(2018) Hartmut Jaeschke et al.   FOOD AND CHEMICAL TOXICOLOGY

Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives

(2018) Anup Ramachandran et al.   GENE EXPRESSION

DNA Damage Response Regulates Initiation of Liver Regeneration Following Acetaminophen Overdose

(2018) Prachi Borude et al.   GENE EXPRESSION

Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups

(2018) Weihsueh Chiu   ALTEX-Alternatives to Animal Experimentation

Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective

(2018) Toby J. Athersuch et al.   Toxicology Research

A Framework for Systematic Evaluation and Quantitative Integration of Mechanistic Data in Assessments of Potential Human Carcinogens

(2018) Daniele S Wikoff et al.   TOXICOLOGICAL SCIENCES

Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature

(2017) Thomas M. Caparrotta et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity

(2017) Kuo Du et al.   FOOD AND CHEMICAL TOXICOLOGY

Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers

(2017) Michael H. Court et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IARC use of oxidative stress as key mode of action characteristic for facilitating cancer classification: Glyphosate case example illustrating a lack of robustness in interpretative implementation

(2017) James S. Bus   REGULATORY TOXICOLOGY AND PHARMACOLOGY

How well can carcinogenicity be predicted by high throughput “characteristics of carcinogens” mechanistic data?

(2017) Richard A. Becker et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Improving the International Agency for Research on Cancer's consideration of mechanistic evidence

(2017) Julie Goodman et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The role of MAP2 kinases and p38 kinase in acute murine liver injury models

(2017) Jun Zhang et al.   Cell Death & Disease

Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity

(2016) Kuo Du et al.   ARCHIVES OF TOXICOLOGY

Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen

(2016) Anne van Rongen et al.   CLINICAL PHARMACOKINETICS

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src

(2016) Sanda Win et al.   HEPATOLOGY

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

(2016) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space

(2016) Richard Judson et al.   TOXICOLOGICAL SCIENCES

Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential

(2016) Kuo Du et al.   Redox Biology

Can paracetamol (acetaminophen) be administered to patients with liver impairment?

(2015) Kelly L. Hayward et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis

(2015) Martyn T. Smith et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver

(2015) Jiangting Hu et al.   TOXICOLOGICAL SCIENCES

Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury

(2015) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

(2015) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells

(2015) Yuchao Xie et al.   XENOBIOTICA

Acetaminophen Attenuates Obesity-Related Renal Injury Through ER-Mediated Stress Mechanisms

(2014) Cuifen Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome

(2014) Mitchell R. McGill et al.   HEPATOLOGY

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy

(2014) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes

(2014) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

(2013) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver

(2013) Hong-Min Ni et al.   Redox Biology

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans

(2012) Marlon J.A. Jetten et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

(2012) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Acetaminophen-induced differentiation of human breast cancer stem cells and inhibition of tumor xenograft growth in mice

(2011) Masaya Takehara et al.   BIOCHEMICAL PHARMACOLOGY

Acetaminophen-cysteine adducts during therapeutic dosing and following overdose

(2011) Kennon J Heard et al.   BMC GASTROENTEROLOGY

Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition

(2011) Amanda LoGuidice et al.   HEPATOLOGY

Activation of autophagy protects against acetaminophen-induced hepatotoxicity

(2011) Hong-Min Ni et al.   HEPATOLOGY

Acute kidney injury in patients admitted to a liver intensive therapy unit with paracetamol-induced hepatotoxicity

(2011) A. O'Riordan et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity

(2011) Anup Ramachandran et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation

(2011) C. David Williams et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acetaminophen: Beyond Pain and Fever-Relieving

(2011) Eric R. Blough et al.   Frontiers in Pharmacology

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

(2010) Anup Ramachandran et al.   FREE RADICAL RESEARCH

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

(2010) Mitchell R. McGill et al.   HEPATOLOGY

Lysosomal Iron Mobilization and Induction of the Mitochondrial Permeability Transition in Acetaminophen-Induced Toxicity to Mouse Hepatocytes

(2010) Kazuyoshi Kon et al.   TOXICOLOGICAL SCIENCES

The Oxygen Tension Modulates Acetaminophen-Induced Mitochondrial Oxidant Stress and Cell Injury in Cultured Hepatocytes

(2010) Hui-Min Yan et al.   TOXICOLOGICAL SCIENCES

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

(2010) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

(2009) Chieko Saito et al.   HEPATOLOGY

Acetaminophen normalizes glucose homeostasis in mouse models for diabetes

(2008) Howard G. Shertzer et al.   BIOCHEMICAL PHARMACOLOGY

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

(2008) Hayato Nakagawa et al.   GASTROENTEROLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paracetamol (Acetaminophen): mechanisms of action

(2008) BRIAN J. ANDERSON   PEDIATRIC ANESTHESIA

Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: Effect on HMG-CoA synthase

(2008) Kelly K. Andringa et al.   TOXICOLOGY LETTERS

Acetaminophen inhibits prostanoid synthesis by scavenging the PGHS-activator peroxynitrite

(2007) Stefan Schildknecht et al.   FASEB JOURNAL