The endocannabinoid system in the amygdala and modulation of fear

Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10‐2474

(2020) Maria‐João Bonifácio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening

(2020) David J. Marcus et al.   NEURON

The endocannabinoid hydrolase FAAH is an allosteric enzyme

(2020) Enrico Dainese et al.   Scientific Reports

2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics

(2020) Gaurav Bedse et al.   BIOLOGICAL PSYCHIATRY

Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

(2020) Elliot D. Mock et al.   Nature Chemical Biology

G-Protein-Coupled Receptors in Astrocyte–Neuron Communication

(2020) Paulo Kofuji et al.   NEUROSCIENCE

Function and mechanisms of memory destabilization and reconsolidation after retrieval

(2020) Satoshi KIDA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Cannabinoid modulation of corticolimbic activation to threat in trauma-exposed adults: a preliminary study

(2020) Christine A. Rabinak et al.   PSYCHOPHARMACOLOGY

Influence of Δ9-tetrahydrocannabinol on long-term neural correlates of threat extinction memory retention in humans

(2019) Mira Z. Hammoud et al.   NEUROPSYCHOPHARMACOLOGY

Astrocytic Endocannabinoids Mediate Hippocampal Transient Heterosynaptic Depression

(2019) Nathan A. Smith et al.   NEUROCHEMICAL RESEARCH

Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial

(2019) Leah M. Mayo et al.   BIOLOGICAL PSYCHIATRY

Structural and Functional Remodeling of Amygdala GABAergic Synapses in Associative Fear Learning

(2019) Yu Kasugai et al.   NEURON

A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents

(2019) Rati Kailash Prasad Tripathi   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans

(2019) Heidi C. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral repeated-dose toxicity studies of BIA 10–2474 in beagle dogs

(2019) Jerry F. Hardisty et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement

(2018) Adar Adamsky et al.   CELL

Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD

(2018) Sharon Fidelman et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction

(2018) Roger Marek et al.   NATURE NEUROSCIENCE

Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

(2018) Roger Marek et al.   NATURE NEUROSCIENCE

Fatty-acid–binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses

(2018) Samir Haj-Dahmane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fear extinction requires infralimbic cortex projections to the basolateral amygdala

(2018) Daniel W. Bloodgood et al.   Translational Psychiatry

Inhibition of Diacylglycerol Lipase Impairs Fear Extinction in Mice

(2018) Victoria S. Cavener et al.   Frontiers in Neuroscience

Upregulation of Anandamide Hydrolysis in the Basolateral Complex of Amygdala Reduces Fear Memory Expression and Indices of Stress and Anxiety

(2018) Maria Morena et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of fear learning and extinction: synaptic plasticity–fear memory connection

(2018) Natalia V. Luchkina et al.   PSYCHOPHARMACOLOGY

The Endocannabinoid System and Oligodendrocytes in Health and Disease

(2018) Alexander A. Ilyasov et al.   Frontiers in Neuroscience

Histaminergic Neurotransmission as a Gateway for the Cognitive Effect of Oleoylethanolamide in Contextual Fear Conditioning

(2017) Gustavo Provensi et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Ramelteon Improves Post-traumatic Stress Disorder-Like Behaviors Exhibited by Fatty Acid-Binding Protein 3 Null Mice

(2017) Yasushi Yabuki et al.   MOLECULAR NEUROBIOLOGY

Synapse-specific astrocyte gating of amygdala-related behavior

(2017) Mario Martin-Fernandez et al.   NATURE NEUROSCIENCE

Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?

(2017) Cecilia J Hillard   NEUROPSYCHOPHARMACOLOGY

Enhancing Endocannabinoid Neurotransmission Augments The Efficacy of Extinction Training and Ameliorates Traumatic Stress-Induced Behavioral Alterations in Rats

(2017) Maria Morena et al.   NEUROPSYCHOPHARMACOLOGY

Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder

(2017) Matthew N Hill et al.   NEUROPSYCHOPHARMACOLOGY

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

(2017) Annelot C. M. van Esbroeck et al.   SCIENCE

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure

(2017) Rebecca J. Bluett et al.   Nature Communications

FAAHGene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence

(2016) Primavera A. Spagnolo et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain

(2016) Emma Leishman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Anxiety, Stress, and Fear Response in Mice With Reduced Endocannabinoid Levels

(2016) Imke Jenniches et al.   BIOLOGICAL PSYCHIATRY

FAAH inhibitors in the limelight, but regrettably

(2016) Christophe Mallet et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Involvement of the infralimbic cortex and CA1 hippocampal area in reconsolidation of a contextual fear memory through CB1 receptors: Effects of CP55,940

(2016) Fabiana Santana et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Bridging the Gap : Towards a cell-type specific understanding of neural circuits underlying fear behaviors

(2016) K.M. McCullough et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Renewal of extinguished fear activates ventral hippocampal neurons projecting to the prelimbic and infralimbic cortices in rats

(2016) Qian Wang et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Projection-Specific Dynamic Regulation of Inhibition in Amygdala Micro-Circuits

(2016) Elisabeth Vogel et al.   NEURON

Direct Ventral Hippocampal-Prefrontal Input Is Required for Anxiety-Related Neural Activity and Behavior

(2016) Nancy Padilla-Coreano et al.   NEURON

Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse

(2016) J.F. Oliveira da Cruz et al.   NEUROSCIENCE

2-arachidonoylglycerol signaling impairs short-term fear extinction

(2016) N D Hartley et al.   Translational Psychiatry

Microglial Cells as a Link between Cannabinoids and the Immune Hypothesis of Psychiatric Disorders

(2016) Sabrina F. Lisboa et al.   Frontiers in Neurology

Fatty Acid-binding Proteins (FABPs) Are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)

(2015) Matthew W. Elmes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fatty Acid Amide Hydrolase C385A Variant Affects Brain Binding of the Positron Emission Tomography Tracer [11C]CURB

(2015) Isabelle Boileau et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Revisiting the Role of Infralimbic Cortex in Fear Extinction with Optogenetics

(2015) F. H. Do-Monte et al.   JOURNAL OF NEUROSCIENCE

Basomedial amygdala mediates top-down control of anxiety and fear

(2015) Avishek Adhikari et al.   NATURE

The endocannabinoid system in guarding against fear, anxiety and stress

(2015) Beat Lutz et al.   NATURE REVIEWS NEUROSCIENCE

Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids

(2015) Ozge Gunduz-Cinar et al.   NEUROPSYCHOPHARMACOLOGY

2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons

(2015) Alvaro Llorente-Berzal et al.   PSYCHOPHARMACOLOGY

FAAH genetic variation enhances fronto-amygdala function in mouse and human

(2015) Iva Dincheva et al.   Nature Communications

Combination of fluoxetine and extinction treatments forms a unique synaptic protein profile that correlates with long-term fear reduction in adult mice

(2014) Dina Popova et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Fatty Acid-binding Protein 5 (FABP5) Regulates Cognitive Function Both by Decreasing Anandamide Levels and by Activating the Nuclear Receptor Peroxisome Proliferator-activated Receptor β/δ (PPARβ/δ) in the Brain

(2014) Shuiliang Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting cells with single vectors using multiple-feature Boolean logic

(2014) Lief E Fenno et al.   NATURE METHODS

Cell-specific STORM super-resolution imaging reveals nanoscale organization of cannabinoid signaling

(2014) Barna Dudok et al.   NATURE NEUROSCIENCE

Long-Range Connectivity Defines Behavioral Specificity of Amygdala Neurons

(2014) Verena Senn et al.   NEURON

Astrocytes in endocannabinoid signalling

(2014) M. Navarrete et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Effects of endocannabinoid and endovanilloid systems on aversive memory extinction

(2013) Daniela Laricchiuta et al.   BEHAVIOURAL BRAIN RESEARCH

Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders

(2013) Carola Schaefer et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Transport of endocannabinoids across the plasma membrane and within the cell

(2013) Christopher J. Fowler   FEBS Journal

Cannabinoid CB1 Receptor in Dorsal Telencephalic Glutamatergic Neurons: Distinctive Sufficiency for Hippocampus-Dependent and Amygdala-Dependent Synaptic and Behavioral Functions

(2013) S. Ruehle et al.   JOURNAL OF NEUROSCIENCE

Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study

(2013) A Neumeister et al.   MOLECULAR PSYCHIATRY

Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression

(2013) Julien Courtin et al.   NATURE

The contextual brain: implications for fear conditioning, extinction and psychopathology

(2013) Stephen Maren et al.   NATURE REVIEWS NEUROSCIENCE

From Pavlov to PTSD: The extinction of conditioned fear in rodents, humans, and anxiety disorders

(2013) Michael B. VanElzakker et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Cannabinoid modulation of prefrontal–limbic activation during fear extinction learning and recall in humans

(2013) Christine A. Rabinak et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Fear Extinction Causes Target-Specific Remodeling of Perisomatic Inhibitory Synapses

(2013) Stéphanie Trouche et al.   NEURON

Acute and chronic effects of selective serotonin reuptake inhibitor treatment on fear conditioning: Implications for underlying fear circuits

(2013) N.S. Burghardt et al.   NEUROSCIENCE

Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks

(2013) Matthew N. Hill et al.   PSYCHONEUROENDOCRINOLOGY

Amygdala FAAH and anandamide: mediating protection and recovery from stress

(2013) Ozge Gunduz-Cinar et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Computational search for hypotheses concerning the endocannabinoid contribution to the extinction of fear conditioning

(2013) Thomas J. Anastasio   Frontiers in Computational Neuroscience

Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD

(2012) Jing Han et al.   CELL

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

(2012) Jimmy Stehberg et al.   FASEB JOURNAL

Bimodal Control of Fear-Coping Strategies by CB1 Cannabinoid Receptors

(2012) M. Metna-Laurent et al.   JOURNAL OF NEUROSCIENCE

Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure

(2012) M N Hill et al.   MOLECULAR PSYCHIATRY

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

(2012) O Gunduz-Cinar et al.   MOLECULAR PSYCHIATRY

Gating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs

(2012) Francisco Sotres-Bayon et al.   NEURON

Cannabinoid facilitation of fear extinction memory recall in humans

(2012) Christine A. Rabinak et al.   NEUROPHARMACOLOGY

Genetic Strain Differences in Learned Fear Inhibition Associated with Variation in Neuroendocrine, Autonomic and Amygdala Dendritic Phenotypes

(2012) Marguerite C Camp et al.   NEUROPSYCHOPHARMACOLOGY

Failure to extinguish fear and genetic variability in the human cannabinoid receptor 1

(2012) I Heitland et al.   Translational Psychiatry

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

(2011) J. R. Savinainen et al.   Acta Physiologica

Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress

(2011) Mohammed R. Milad et al.   Annual Review of Psychology

Polymodal activation of the endocannabinoid system in the extended amygdala

(2011) Nagore Puente et al.   NATURE NEUROSCIENCE

A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex

(2011) Hiroki Taniguchi et al.   NEURON

Reversible Gating of Endocannabinoid Plasticity in the Amygdala by Chronic Stress: A Potential Role for Monoacylglycerol Lipase Inhibition in the Prevention of Stress-Induced Behavioral Adaptation

(2011) Joshua J Sumislawski et al.   NEUROPSYCHOPHARMACOLOGY

Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus

(2011) T. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fear Erasure in Mice Requires Synergy Between Antidepressant Drugs and Extinction Training

(2011) N. N. Karpova et al.   SCIENCE

Memory for Fear Extinction Requires mGluR5-Mediated Activation of Infralimbic Neurons

(2010) Darah E. Fontanez-Nuin et al.   CEREBRAL CORTEX

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

(2010) William R Marrs et al.   NATURE NEUROSCIENCE

Endocannabinoids Potentiate Synaptic Transmission through Stimulation of Astrocytes

(2010) Marta Navarrete et al.   NEURON

Dissociable Roles of Prelimbic and Infralimbic Cortices, Ventral Hippocampus and Basolateral Amygdala in the Expression and Extinction of Conditioned Fear

(2010) Demetrio Sierra-Mercado et al.   NEUROPSYCHOPHARMACOLOGY

Biomarkers of Endocannabinoid System Activation in Severe Obesity

(2010) Jack C. Sipe et al.   PLoS One

Sustained Conditioned Responses in Prelimbic Prefrontal Neurons Are Correlated with Fear Expression and Extinction Failure

(2009) A. Burgos-Robles et al.   JOURNAL OF NEUROSCIENCE

Suppression of Amygdalar Endocannabinoid Signaling by Stress Contributes to Activation of the Hypothalamic–Pituitary–Adrenal Axis

(2009) Matthew N Hill et al.   NEUROPSYCHOPHARMACOLOGY

Repeated Homotypic Stress Elevates 2-Arachidonoylglycerol Levels and Enhances Short-Term Endocannabinoid Signaling at Inhibitory Synapses in Basolateral Amygdala

(2009) Sachin Patel et al.   NEUROPSYCHOPHARMACOLOGY

Identification of intracellular carriers for the endocannabinoid anandamide

(2009) M. Kaczocha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perineuronal Nets Protect Fear Memories from Erasure

(2009) N. Gogolla et al.   SCIENCE

The Role of Prefrontal Cortex CB1 Receptors in the Modulation of Fear Memory

(2008) H.-C. Lin et al.   CEREBRAL CORTEX

Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling

(2008) K. Kamprath et al.   GENES BRAIN AND BEHAVIOR

Impaired Fear Extinction Learning and Cortico-Amygdala Circuit Abnormalities in a Common Genetic Mouse Strain

(2008) K. Hefner et al.   JOURNAL OF NEUROSCIENCE

Chronic cannabinoid administration in vivo compromises extinction of fear memory

(2008) H.-C. Lin et al.   LEARNING & MEMORY

Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdala

(2008) S. C. Azad et al.   LEARNING & MEMORY

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

(2008) István Katona et al.   NATURE MEDICINE

Short- and long-term effects of cannabinoids on the extinction of contextual fear memory in rats

(2008) Fabrício A. Pamplona et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Endocannabinoids Mediate Neuron-Astrocyte Communication

(2008) Marta Navarrete et al.   NEURON

Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin

(2008) B. D. Heifets et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the cyclic-AMP/PKA cascade and of P/Q-type Ca++ channels in endocannabinoid-mediated long-term depression in the nucleus accumbens

(2007) Susana Mato et al.   NEUROPHARMACOLOGY

Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice

(2007) David J. Rademacher et al.   NEUROPHARMACOLOGY