Fatty Acid-binding Proteins (FABPs) Are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)

Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

(2014) Orrin Devinsky et al.   EPILEPSIA

Fatty Acid-binding Protein 5 (FABP5) Regulates Cognitive Function Both by Decreasing Anandamide Levels and by Activating the Nuclear Receptor Peroxisome Proliferator-activated Receptor β/δ (PPARβ/δ) in the Brain

(2014) Shuiliang Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Fatty Acid Binding Proteins Elevates Brain Anandamide Levels and Produces Analgesia

(2014) Martin Kaczocha et al.   PLoS One

Involvement of Fatty Acid Amide Hydrolase and Fatty Acid Binding Protein 5 in the Uptake of Anandamide by Cell Lines with Different Levels of Fatty Acid Amide Hydrolase Expression: A Pharmacological Study

(2014) Emmelie Björklund et al.   PLoS One

Crystallographic study of FABP5 as an intracellular endocannabinoid transporter

(2014) Benoît Sanson et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Impact of enzymatic and alkaline hydrolysis on CBD concentration in urine

(2013) Mateus M. Bergamaschi et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Exogenous Delta9-Tetrahydrocannabinol Influences Circulating Endogenous Cannabinoids in Humans

(2013) Carmen Walter et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

The Endocannabinoid System and the Brain

(2012) Raphael Mechoulam et al.   Annual Review of Psychology

A Water-Based Mechanism of Specificity and Resistance for Lapatinib with ErbB Family Kinases

(2012) Yulin Huang et al.   BIOCHEMISTRY

A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis

(2012) R. M. Langford et al.   JOURNAL OF NEUROLOGY

Analysis of cannabinoids in laser-microdissected trichomes of medicinal Cannabis sativa using LCMS and cryogenic NMR

(2012) Nizar Happyana et al.   PHYTOCHEMISTRY

Targeting Fatty Acid Binding Protein (FABP) Anandamide Transporters – A Novel Strategy for Development of Anti-Inflammatory and Anti-Nociceptive Drugs

(2012) William T. Berger et al.   PLoS One

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

(2012) F M Leweke et al.   Translational Psychiatry

Endocannabinoid tone versus constitutive activity of cannabinoid receptors

(2011) Allyn C. Howlett et al.   BRITISH JOURNAL OF PHARMACOLOGY

Binding of δ9-tetrahydrocannabinol and diazepam to human serum albumin

(2011) Gabriella Fanali et al.   IUBMB LIFE

Fatty Acid-binding Proteins TransportN-Acylethanolamines to Nuclear Receptors and Are Targets of Endocannabinoid Transport Inhibitors

(2011) Martin Kaczocha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implementation and evaluation of a docking-rescoring method using molecular footprint comparisons

(2011) Trent E. Balius et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)

(2011) X. Min et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of cannabinoids and cannabinoid-enrichedCannabisextracts on TRP channels and endocannabinoid metabolic enzymes

(2010) Luciano De Petrocellis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Docking Validation Resources: Protein Family and Ligand Flexibility Experiments

(2010) Sudipto Mukherjee et al.   Journal of Chemical Information and Modeling

The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors

(2010) Felipe V. Gomes et al.   PSYCHOPHARMACOLOGY

Quantitative Prediction of Fold Resistance for Inhibitors of EGFR

(2009) Trent E. Balius et al.   BIOCHEMISTRY

Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors

(2009) TV Zanelati et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

Molecular Identification of Albumin and Hsp70 as Cytosolic Anandamide-Binding Proteins

(2009) Sergio Oddi et al.   CHEMISTRY & BIOLOGY

Enhancement of the hypotensive effects of intrathecally injected endocannabinoids by the entourage compound palmitoylethanolamide

(2009) María del Carmen García et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lipid Droplets Are Novel Sites ofN-Acylethanolamine Inactivation by Fatty Acid Amide Hydrolase-2

(2009) Martin Kaczocha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures

(2009) Mauro Mileni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of intracellular carriers for the endocannabinoid anandamide

(2009) M. Kaczocha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

(2009) Angelo A. Izzo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

(2008) Masato Furuhashi et al.   NATURE REVIEWS DRUG DISCOVERY

The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors

(2008) Barbara Costa et al.   PAIN

Human Microglial Cells Synthesize Albumin in Brain

(2008) Sung-Min Ahn et al.   PLoS One

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

(2008) M. Mileni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin

(2007) R G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY