Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids

Toward a translational approach to targeting the endocannabinoid system in posttraumatic stress disorder: A critical review of preclinical research

(2015) Santiago Papini et al.   BIOLOGICAL PSYCHOLOGY

BDNF Interacts with Endocannabinoids to Regulate Cocaine-Induced Synaptic Plasticity in Mouse Midbrain Dopamine Neurons

(2015) P. Zhong et al.   JOURNAL OF NEUROSCIENCE

Neuronal circuits for fear and anxiety

(2015) Philip Tovote et al.   NATURE REVIEWS NEUROSCIENCE

Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

(2015) N. Singewald et al.   PHARMACOLOGY & THERAPEUTICS

Translational evidence for a role of endocannabinoids in the etiology and treatment of posttraumatic stress disorder

(2015) Alexander Neumeister et al.   PSYCHONEUROENDOCRINOLOGY

FAAH genetic variation enhances fronto-amygdala function in mouse and human

(2015) Iva Dincheva et al.   Nature Communications

Prefrontal inputs to the amygdala instruct fear extinction memory formation

(2015) O. Bukalo et al.   Science Advances

Inhibition of FAAH, TRPV1, and COX2 by NSAID–serotonin conjugates

(2014) Tyler M. Rose et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders

(2014) Olena Bukalo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Combination of fluoxetine and extinction treatments forms a unique synaptic protein profile that correlates with long-term fear reduction in adult mice

(2014) Dina Popova et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Multiple Mechanistically Distinct Modes of Endocannabinoid Mobilization at Central Amygdala Glutamatergic Synapses

(2014) Teniel S. Ramikie et al.   NEURON

Interaction between the Cholecystokinin and Endogenous Cannabinoid Systems in Cued Fear Expression and Extinction Retention

(2014) Mallory E Bowers et al.   NEUROPSYCHOPHARMACOLOGY

Endocannabinoid Signaling within the Basolateral Amygdala Integrates Multiple Stress Hormone Effects on Memory Consolidation

(2014) Piray Atsak et al.   NEUROPSYCHOPHARMACOLOGY

The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis

(2014) Andrea Navarria et al.   PHARMACOLOGICAL RESEARCH

Genetic Disruption of 2-Arachidonoylglycerol Synthesis Reveals a Key Role for Endocannabinoid Signaling in Anxiety Modulation

(2014) Brian C. Shonesy et al.   Cell Reports

Two weeks of pretreatment with escitalopram facilitates extinction learning in healthy individuals

(2013) Eric Bui et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study

(2013) A Neumeister et al.   MOLECULAR PSYCHIATRY

Prefrontal single-unit firing associated with deficient extinction in mice

(2013) Paul J. Fitzgerald et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Fear Extinction Causes Target-Specific Remodeling of Perisomatic Inhibitory Synapses

(2013) Stéphanie Trouche et al.   NEURON

Caloric Restriction Enhances Fear Extinction Learning in Mice

(2013) Megan C Riddle et al.   NEUROPSYCHOPHARMACOLOGY

Acute and chronic effects of selective serotonin reuptake inhibitor treatment on fear conditioning: Implications for underlying fear circuits

(2013) N.S. Burghardt et al.   NEUROSCIENCE

Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks

(2013) Matthew N. Hill et al.   PSYCHONEUROENDOCRINOLOGY

Amygdala FAAH and anandamide: mediating protection and recovery from stress

(2013) Ozge Gunduz-Cinar et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

N-Arachidonoyl-serotonin in the basolateral amygdala increases anxiolytic behavior in the elevated plus maze

(2012) Catherine S. John et al.   BEHAVIOURAL BRAIN RESEARCH

Fear extinction and BDNF: translating animal models of PTSD to the clinic

(2012) R. Andero et al.   GENES BRAIN AND BEHAVIOR

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

(2012) O Gunduz-Cinar et al.   MOLECULAR PSYCHIATRY

Stimulation of serotonin 2A receptors facilitates consolidation and extinction of fear memory in C57BL/6J mice

(2012) Gongliang Zhang et al.   NEUROPHARMACOLOGY

Genetic Strain Differences in Learned Fear Inhibition Associated with Variation in Neuroendocrine, Autonomic and Amygdala Dendritic Phenotypes

(2012) Marguerite C Camp et al.   NEUROPSYCHOPHARMACOLOGY

Genetic Dissection of the Role of Cannabinoid Type-1 Receptors in the Emotional Consequences of Repeated Social Stress in Mice

(2012) Sarah Dubreucq et al.   NEUROPSYCHOPHARMACOLOGY

Acute Stress Increases Circulating Anandamide and Other N-Acylethanolamines in Healthy Humans

(2012) Andrea Dlugos et al.   NEUROPSYCHOPHARMACOLOGY

Endocannabinoid system and mood disorders: Priming a target for new therapies

(2012) Vincenzo Micale et al.   PHARMACOLOGY & THERAPEUTICS

Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memory

(2012) C. A. Hartley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear

(2012) Olivier Deschaux et al.   PSYCHOPHARMACOLOGY

Individual differences in recovery from traumatic fear

(2012) Andrew Holmes et al.   TRENDS IN NEUROSCIENCES

Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress

(2011) Mohammed R. Milad et al.   Annual Review of Psychology

Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice

(2011) Sudhir N. Umathe et al.   BEHAVIOURAL BRAIN RESEARCH

Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus

(2011) T. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fear Erasure in Mice Requires Synergy Between Antidepressant Drugs and Extinction Training

(2011) N. N. Karpova et al.   SCIENCE

Inhibitor of Fatty Acid Amide Hydrolase Normalizes Cardiovascular Function in Hypertension without Adverse Metabolic Effects

(2010) Grzegorz Godlewski et al.   CHEMISTRY & BIOLOGY

BDNF Evokes Release of Endogenous Cannabinoids at Layer 2/3 Inhibitory Synapses in the Neocortex

(2010) Fouad Lemtiri-Chlieh et al.   JOURNAL OF NEUROPHYSIOLOGY

Genetic Deletion of Fatty Acid Amide Hydrolase Alters Emotional Behavior and Serotonergic Transmission in the Dorsal Raphe, Prefrontal Cortex and Hippocampus

(2010) Francis Rodriguez Bambico et al.   NEUROPSYCHOPHARMACOLOGY

Chronic treatment with fluoxetine prevents the return of extinguished auditory-cued conditioned fear

(2010) Olivier Deschaux et al.   PSYCHOPHARMACOLOGY

Antidepressant response to chronic citalopram treatment in eight inbred mouse strains

(2010) Jianwei Jiao et al.   PSYCHOPHARMACOLOGY

Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice

(2010) Tommaso Cassano et al.   PSYCHOPHARMACOLOGY

Induction of Fear Extinction with Hippocampal-Infralimbic BDNF

(2010) J. Peters et al.   SCIENCE

Lack of CB1receptor activity impairs serotonergic negative feedback

(2009) Ester Aso et al.   JOURNAL OF NEUROCHEMISTRY

Long-Term Fluoxetine Treatment Modulates Cannabinoid Type 1 Receptor-Mediated Inhibition of Adenylyl Cyclase in the Rat Prefrontal Cortex through 5-Hydroxytryptamine1A Receptor-Dependent Mechanisms

(2009) S. Mato et al.   MOLECULAR PHARMACOLOGY

Stress, memory and the amygdala

(2009) Benno Roozendaal et al.   NATURE REVIEWS NEUROSCIENCE

Repeated Homotypic Stress Elevates 2-Arachidonoylglycerol Levels and Enhances Short-Term Endocannabinoid Signaling at Inhibitory Synapses in Basolateral Amygdala

(2009) Sachin Patel et al.   NEUROPSYCHOPHARMACOLOGY

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids

(2009) Matthew N. Hill et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Perineuronal Nets Protect Fear Memories from Erasure

(2009) N. Gogolla et al.   SCIENCE

Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders - the case of yohimbine

(2009) Andrew Holmes et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Divergent Effects of Genetic Variation in Endocannabinoid Signaling on Human Threat- and Reward-Related Brain Function

(2008) Ahmad R. Hariri et al.   BIOLOGICAL PSYCHIATRY

Immunohistochemical localization of CB1 cannabinoid receptors in frontal cortex and related limbic areas in obese Zucker rats: Effects of chronic fluoxetine treatment

(2008) J. Zarate et al.   BRAIN RESEARCH

Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents

(2008) Matthew N. Hill et al.   JOURNAL OF NEURAL TRANSMISSION

Switching on and off fear by distinct neuronal circuits

(2008) Cyril Herry et al.   NATURE

Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels

(2008) Vincenzo Micale et al.   NEUROPSYCHOPHARMACOLOGY

Serum Endocannabinoid Content is Altered in Females with Depressive Disorders: A Preliminary Report

(2008) M. Hill et al.   PHARMACOPSYCHIATRY

Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin

(2008) B. D. Heifets et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of adolescent fluoxetine treatment on fear-, anxiety- or stress-related behaviors in C57BL/6J or BALB/cJ mice

(2008) Maxine Norcross et al.   PSYCHOPHARMACOLOGY