Axon death signalling in Wallerian degeneration among species and in disease

Rapid depletion of ESCRT protein Vps4 underlies injury-induced autophagic impediment and Wallerian degeneration

(2019) Haiqiong Wang et al.   Science Advances

Dying Neurons Utilize Innate Immune Signaling to Prime Glia for Phagocytosis during Development

(2019) Colleen N. McLaughlin et al.   DEVELOPMENTAL CELL

Genetic inhibition of CRMP2 phosphorylation delays Wallerian degeneration after optic nerve injury

(2019) Yuki Kinoshita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence

(2019) Marshall Lukacs et al.   EXPERIMENTAL NEUROLOGY

Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia

(2019) Peter Huppke et al.   EXPERIMENTAL NEUROLOGY

Injured Axons Instruct Schwann Cells to Build Constricting Actin Spheres to Accelerate Axonal Disintegration

(2019) Adrien Vaquié et al.   Cell Reports

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis

(2018) Owen M Peters et al.   HUMAN MOLECULAR GENETICS

PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2

(2018) Muriel Desbois et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary Traumatic Axonopathy in Mice Subjected to Impact Acceleration: A Reappraisal of Pathology and Mechanisms with High-Resolution Anatomical Methods

(2018) Nikolaos K. Ziogas et al.   JOURNAL OF NEUROSCIENCE

Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration

(2018) Jonathan E. Farley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maintenance mechanisms of circuit-integrated axons

(2018) Vittoria Mariano et al.   CURRENT OPINION IN NEUROBIOLOGY

Regulation of neuronal/axonal degeneration by ZNRF1 ubiquitin ligase

(2018) Toshiyuki Araki et al.   NEUROSCIENCE RESEARCH

Palmitoylation enables MAPK-dependent proteostasis of axon survival factors

(2018) Daniel W. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic opportunities and pitfalls in the treatment of axon degeneration

(2018) David J. Simon et al.   CURRENT OPINION IN NEUROLOGY

Phosphatidylserine is a marker for axonal debris engulfment but its exposure can be decoupled from degeneration

(2018) Vered Shacham-Silverberg et al.   Cell Death & Disease

Editorial: Axonopathy in Neurodegenerative Disease

(2018) Robert W. Burgess et al.   Frontiers in Neuroscience

NAD Metabolism in Cancer Therapeutics

(2018) Keisuke Yaku et al.   Frontiers in Oncology

GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration

(2017) Shuji Wakatsuki et al.   JOURNAL OF CELL BIOLOGY

Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy

(2017) Elliot Turkiew et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly

(2017) Lukas J. Neukomm et al.   NEURON

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

(2017) Tsai-Yi Lu et al.   Nature Communications

Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons

(2017) Yousuf O. Ali et al.   Scientific Reports

Sarm1 Deletion, but Not Wld S , Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

(2017) Jonathan Gilley et al.   Cell Reports

Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling

(2017) Michael Krieg et al.   eLife

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

(2017) Lauren J Walker et al.   eLife

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice

(2016) Stefanie Geisler et al.   BRAIN

Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lackingSarm1

(2016) Nils Henninger et al.   BRAIN

TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance

(2016) M. R. C. Bhattacharya et al.   JOURNAL OF NEUROSCIENCE

Traumatic Axonal Injury: Mechanisms and Translational Opportunities

(2016) Ciaran S. Hill et al.   TRENDS IN NEUROSCIENCES

Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity

(2016) Maria D. Purice et al.   Nature Communications

An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2

(2016) Yuya Yamagishi et al.   Cell Reports

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

(2016) Yo Sasaki et al.   eLife

Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration

(2016) Jian-Nan Zhang et al.   Scientific Reports

Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit

(2015) Jing Yang et al.   CELL

Live Imaging of Calcium Dynamics during Axon Degeneration Reveals Two Functionally Distinct Phases of Calcium Influx

(2015) M. E. Vargas et al.   JOURNAL OF NEUROSCIENCE

Wallerian Degeneration in the Optic Nerve Stretch-Injury Model of Traumatic Brain Injury: A Stereological Analysis

(2015) William L. Maxwell et al.   JOURNAL OF NEUROTRAUMA

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress

(2015) Kai Ruan et al.   Nature Communications

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons

(2015) Jonathan Gilley et al.   Cell Reports

Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca 2+ Influx but Only Modestly Influenced by Mitochondria

(2015) Andrea Loreto et al.   Cell Reports

Changes in Neurofilament and Microtubule Distribution following Focal Axon Compression

(2015) Adam J. Fournier et al.   PLoS One

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

(2014) M Di Stefano et al.   CELL DEATH AND DIFFERENTIATION

Drosophila Models of Neuronal Injury

(2014) T. M. Rooney et al.   ILAR JOURNAL

Calcium Release from Intra-Axonal Endoplasmic Reticulum Leads to Axon Degeneration through Mitochondrial Dysfunction

(2014) R. Villegas et al.   JOURNAL OF NEUROSCIENCE

Wallerian degeneration: an emerging axon death pathway linking injury and disease

(2014) Laura Conforti et al.   NATURE REVIEWS NEUROSCIENCE

Rapid in vivo forward genetic approach for identifying axon death genes inDrosophila

(2014) Lukas J. Neukomm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse cellular and molecular modes of axon degeneration

(2014) Lukas J. Neukomm et al.   TRENDS IN CELL BIOLOGY

Characterization of the definitive classical calpain family of vertebrates using phylogenetic, evolutionary and expression analyses

(2014) D. J. Macqueen et al.   Open Biology

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2

(2013) J. Gilley et al.   JOURNAL OF NEUROSCIENCE

Sodium and Potassium Currents Influence Wallerian Degeneration of Injured Drosophila Axons

(2013) B. Mishra et al.   JOURNAL OF NEUROSCIENCE

Maintaining energy homeostasis is an essential component of WldS-mediated axon protection

(2013) Hua Shen et al.   NEUROBIOLOGY OF DISEASE

Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration

(2013) Marek Ma et al.   NEUROBIOLOGY OF DISEASE

Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin

(2013) Jing Yang et al.   NEURON

Mitochondrial swelling and microtubule depolymerization are associated with energy depletion in axon degeneration

(2013) J.Y. Park et al.   NEUROSCIENCE

Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo

(2013) Stefan Milde et al.   Scientific Reports

The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction

(2013) Elisabetta Babetto et al.   Cell Reports

Subcellular Localization Determines the Stability and Axon Protective Capacity of Axon Survival Factor Nmnat2

(2013) Stefan Milde et al.   PLOS BIOLOGY

T-cell death following immune activation is mediated by mitochondria-localized SARM

(2012) P Panneerselvam et al.   CELL DEATH AND DIFFERENTIATION

A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat in Maintaining Axonal Integrity

(2012) Yanshan Fang et al.   CURRENT BIOLOGY

WldS Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca2+ Buffering

(2012) Michelle A. Avery et al.   CURRENT BIOLOGY

Axon degeneration in Parkinson's disease

(2012) Robert E. Burke et al.   EXPERIMENTAL NEUROLOGY

Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types

(2012) Rosario Villegas et al.   Neural Development

Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention

(2012) W. Grisold et al.   NEURO-ONCOLOGY

Intra-axonal calcium changes after axotomy in wild-type and slow Wallerian degeneration axons

(2012) R. Adalbert et al.   NEUROSCIENCE

SCG10 is a JNK target in the axonal degeneration pathway

(2012) J. E. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons

(2012) K. Xu et al.   SCIENCE

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

(2012) Xin Xiong et al.   PLOS BIOLOGY

A Monument of Inefficiency: The Presumed Course of the Recurrent Laryngeal Nerve in Sauropod Dinosaurs

(2011) Mathew J. Wedel   ACTA PALAEONTOLOGICA POLONICA

Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore

(2011) S. A. Barrientos et al.   JOURNAL OF NEUROSCIENCE

Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning

(2010) S. M. Martin et al.   DEVELOPMENT

Axonal Degeneration Is Blocked by Nicotinamide Mononucleotide Adenylyltransferase (Nmnat) Protein Transduction into Transected Axons

(2010) Yo Sasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting NMNAT1 to Axons and Synapses Transforms Its Neuroprotective Potency In Vivo

(2010) E. Babetto et al.   JOURNAL OF NEUROSCIENCE

Overexpression of Wldsor Nmnat2 in mauthner cells by single-cell electroporation delays axon degeneration in live zebrafish

(2010) Yan Feng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration

(2010) Gerd Meyer zu Horste et al.   NEUROBIOLOGY OF DISEASE

Calpain as a therapeutic target in traumatic brain injury

(2010) Kathryn E. Saatman et al.   Neurotherapeutics

Mechanisms of acute axonal degeneration in the optic nerve in vivo

(2010) J. Knoferle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system

(2009) James C. Vickers et al.   BRAIN RESEARCH BULLETIN

WldSrequires Nmnat1 enzymatic activity and N16–VCP interactions to suppress Wallerian degeneration

(2009) Michelle A. Avery et al.   JOURNAL OF CELL BIOLOGY

Non-Nuclear WldS Determines Its Neuroprotective Efficacy for Axons and Synapses In Vivo

(2009) B. Beirowski et al.   JOURNAL OF NEUROSCIENCE

Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum

(2009) W. Matsuda et al.   JOURNAL OF NEUROSCIENCE

Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration In Vivo

(2009) Y. Sasaki et al.   JOURNAL OF NEUROSCIENCE

A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

(2009) Bradley R Miller et al.   NATURE NEUROSCIENCE

Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity

(2009) Tingting Yan et al.   NEUROCHEMISTRY INTERNATIONAL

Stretch growth of integrated axon tracts: Extremes and exploitations

(2009) Douglas H. Smith   PROGRESS IN NEUROBIOLOGY