Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula

Activity-Dependent Plasticity of Axo-axonic Synapses at the Axon Initial Segment

(2020) Alejandro Pan-Vazquez et al.   NEURON

Anatomical and single-cell transcriptional profiling of the murine habenular complex

(2020) Michael L Wallace et al.   eLife

Circuits and functions of the lateral habenula in health and in disease

(2020) Hailan Hu et al.   NATURE REVIEWS NEUROSCIENCE

Transcriptional and Spatial Resolution of Cell Types in the Mammalian Habenula

(2020) Yoshiko Hashikawa et al.   NEURON

The Dorsal Lateral Habenula-Interpeduncular Nucleus Pathway Is Essential for Left-Right-Dependent Decision Making in Zebrafish

(2020) Bor-Wei Cherng et al.   Cell Reports

The Zebrafish Dorsolateral Habenula Is Required for Updating Learned Behaviors

(2020) Fabrizio Palumbo et al.   Cell Reports

Punishment-Predictive Cues Guide Avoidance through Potentiation of Hypothalamus-to-Habenula Synapses

(2019) Massimo Trusel et al.   NEURON

A hypothalamus-habenula circuit controls aversion

(2019) Iakovos Lazaridis et al.   MOLECULAR PSYCHIATRY

Neuronal Dynamics Regulating Brain and Behavioral State Transitions

(2019) Aaron S. Andalman et al.   CELL

Stress transforms lateral habenula reward responses into punishment signals

(2019) Steven J. Shabel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A neural circuit for comorbid depressive symptoms in chronic pain

(2019) Wenjie Zhou et al.   NATURE NEUROSCIENCE

Silent synapses dictate cocaine memory destabilization and reconsolidation

(2019) William J. Wright et al.   NATURE NEUROSCIENCE

Three Rostromedial Tegmental Afferents Drive Triply Dissociable Aspects of Punishment Learning and Aversive Valence Encoding

(2019) Hao Li et al.   NEURON

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors

(2019) Ignas Cerniauskas et al.   NEURON

Cortical Synaptic AMPA Receptor Plasticity during Motor Learning

(2019) Richard H. Roth et al.   NEURON

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

(2018) Yihui Cui et al.   NATURE

Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses

(2018) Tara A. LeGates et al.   NATURE

Stochastic synaptic plasticity underlying compulsion in a model of addiction

(2018) Vincent Pascoli et al.   NATURE

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting

(2018) Ankit Awasthi et al.   SCIENCE

Thalamic functions in distributed cognitive control

(2017) Michael M. Halassa et al.   NATURE NEUROSCIENCE

Lateral habenula integration of proactive and retroactive information mediates behavioral flexibility

(2017) P.M. Baker et al.   NEUROSCIENCE

Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward

(2016) A. M. Stamatakis et al.   JOURNAL OF NEUROSCIENCE

Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice

(2016) Salvatore Lecca et al.   NATURE MEDICINE

Stress weakens prefrontal networks: molecular insults to higher cognition

(2015) Amy F T Arnsten   NATURE NEUROSCIENCE

Excitatory Transmission to the Lateral Habenula Is Critical for Encoding and Retrieval of Spatial Memory

(2015) Victor Mathis et al.   NEUROPSYCHOPHARMACOLOGY

An excitatory synapse hypothesis of depression

(2015) Scott M. Thompson et al.   TRENDS IN NEUROSCIENCES

Ongoing behavioral state information signaled in the lateral habenula guides choice flexibility in freely moving rats

(2015) Phillip M. Baker et al.   Frontiers in Behavioral Neuroscience

The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview

(2014) Salvatore Lecca et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pathological circuit function underlying addiction and anxiety disorders

(2014) Andreas Lüthi et al.   NATURE NEUROSCIENCE

Single rodent mesohabenular axons release glutamate and GABA

(2014) David H Root et al.   NATURE NEUROSCIENCE

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

(2014) Amy S Chuong et al.   NATURE NEUROSCIENCE

Deep brain optical measurements of cell type–specific neural activity in behaving mice

(2014) Guohong Cui et al.   Nature Protocols

GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment

(2014) S. J. Shabel et al.   SCIENCE

What's better for me? Fundamental role for lateral habenula in promoting subjective decision biases

(2013) Colin M Stopper et al.   NATURE NEUROSCIENCE

Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance

(2012) Alice M Stamatakis et al.   NATURE NEUROSCIENCE

Neuromodulation of Thought: Flexibilities and Vulnerabilities in Prefrontal Cortical Network Synapses

(2012) Amy F.T. Arnsten et al.   NEURON

Input to the Lateral Habenula from the Basal Ganglia Is Excitatory, Aversive, and Suppressed by Serotonin

(2012) Steven J. Shabel et al.   NEURON

Disconnection and reconnection: the morphological basis of (mal)adaptation to stress

(2012) Nuno Sousa et al.   TRENDS IN NEUROSCIENCES

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

(2011) Bo Li et al.   NATURE

The context counts: Congruent learning and testing environments prevent memory retrieval impairment following stress

(2009) Lars Schwabe et al.   COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE

Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress

(2009) A. B. Hains et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses

(2008) Gina G. Turrigiano   CELL

Decision Making in Recurrent Neuronal Circuits

(2008) Xiao-Jing Wang   NEURON