Dynamin-related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-anchored Mitochondrial Fission Factor

The Mechanoenzymatic Core of Dynamin-related Protein 1 Comprises the Minimal Machinery Required for Membrane Constriction

(2015) Christopher A. Francy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity

(2015) Patrick J. Macdonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiolipin's propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission

(2015) Natalia Stepanyants et al.   MOLECULAR BIOLOGY OF THE CELL

The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1

(2015) Raymond Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamin-related Protein 1 (Drp1) Promotes Structural Intermediates of Membrane Division

(2014) Begoña Ugarte-Uribe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission

(2014) Patrick J. Macdonald et al.   MOLECULAR BIOLOGY OF THE CELL

Specific Interaction with Cardiolipin Triggers Functional Activation of Dynamin-Related Protein 1

(2014) Itsasne Bustillo-Zabalbeitia et al.   PLoS One

Dynamin Assembly Strategies and Adaptor Proteins in Mitochondrial Fission

(2013) Huyen T. Bui et al.   CURRENT BIOLOGY

Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein

(2013) Chris Fröhlich et al.   EMBO JOURNAL

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

(2013) Yu-Chin Su et al.   HUMAN MOLECULAR GENETICS

Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules

(2013) Stefan Strack et al.   JOURNAL OF CELL BIOLOGY

Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration

(2013) Xing Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission

(2013) S. Koirala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances into the understanding of mitochondrial fission

(2012) Kirstin Elgass et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Allosteric Modulation of Drp1 Mechanoenzyme Assembly and Mitochondrial Fission by the Variable Domain

(2012) Stefan Strack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity

(2012) X. Qi et al.   JOURNAL OF CELL SCIENCE

Mitochondrial morphology and cardiovascular disease

(2010) S.-B. Ong et al.   CARDIOVASCULAR RESEARCH

Small Molecule Inhibitors of Mitochondrial Division: Tools that Translate Basic Biological Research into Medicine

(2010) Laura L. Lackner et al.   CHEMISTRY & BIOLOGY

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

A Lethalde NovoMutation in the Middle Domain of the Dynamin-related GTPase Drp1 Impairs Higher Order Assembly and Mitochondrial Division

(2010) Chuang-Rung Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission

(2010) Jason A Mears et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Mutation in the Mitochondrial Fission Gene Dnm1l Leads to Cardiomyopathy

(2010) Houman Ashrafian et al.   PLoS Genetics

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

(2009) Junko Wakabayashi et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial fission and fusion dynamics: the long and short of it

(2008) S B Berman et al.   CELL DEATH AND DIFFERENTIATION

Template-directed Assembly of Signaling Proteins: A Novel Drug Screening and Research Tool

(2008) Anthony L. Shrout et al.   Chemical Biology & Drug Design

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells

(2008) Shilpa Gandre-Babbe et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial fragmentation in neurodegeneration

(2008) Andrew B. Knott et al.   NATURE REVIEWS NEUROSCIENCE