Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity

Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

(2020) Duhyeong Hwang et al.   ADVANCED DRUG DELIVERY REVIEWS

scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

(2019) Jennifer Ocasio et al.   Nature Communications

Poly(2-oxazoline)s based biomaterials: A comprehensive and critical update

(2018) Thomas Lorson et al.   BIOMATERIALS

Antiretroviral concentrations and surrogate measures of efficacy in the brain tissue and CSF of preclinical species

(2018) Nithya Srinivas et al.   XENOBIOTICA

A functional genomics approach to identify pathways of drug resistance in medulloblastoma

(2018) Kelsey C. Bertrand et al.   Acta Neuropathologica Communications

Co-delivery of paclitaxel and cisplatin in poly(2-oxazoline) polymeric micelles: Implications for drug loading, release, pharmacokinetics and outcome of ovarian and breast cancer treatments

(2018) Xiaomeng Wan et al.   BIOMATERIALS

Clinical development of a poly(2-oxazoline) (POZ) polymer therapeutic for the treatment of Parkinson’s disease – Proof of concept of POZ as a versatile polymer platform for drug development in multiple therapeutic indications

(2017) Randall W. Moreadith et al.   EUROPEAN POLYMER JOURNAL

Albumin nanoparticles for glutathione-responsive release of cisplatin: New opportunities for medulloblastoma

(2017) Giuseppina Catanzaro et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The effect of nanoparticle size on the ability to cross the blood–brain barrier: an in vivo study

(2017) Oshra Betzer et al.   Nanomedicine

Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma

(2017) Forrest M. Kievit et al.   Nanomedicine-Nanotechnology Biology and Medicine

Irreversible growth plate fusions in children with medulloblastoma treated with a targeted hedgehog pathway inhibitor

(2017) Giles W. Robinson et al.   Oncotarget

A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity

(2016) Zhijian He et al.   BIOMATERIALS

Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype

(2016) Timothy N. Phoenix et al.   CANCER CELL

ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation

(2016) Patrick Y. Lang et al.   DEVELOPMENT

Nano carriers for drug transport across the blood–brain barrier

(2016) Xinming Li et al.   JOURNAL OF DRUG TARGETING

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

(2016) Tadas Rimkus et al.   Cancers

Formulations for children: problems and solutions

(2015) Hannah K. Batchelor et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice

(2015) Scott E. Williams et al.   DEVELOPMENT

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

(2015) Giles W. Robinson et al.   JOURNAL OF CLINICAL ONCOLOGY

Nanoparticle mediated silencing of DNA repair sensitizes pediatric brain tumor cells to γ-irradiation

(2015) Forrest M. Kievit et al.   Molecular Oncology

Systemic toxicity induced by paclitaxel in vivo is associated with the solvent cremophor EL through oxidative stress-driven mechanisms

(2014) Fernanda C. Campos et al.   FOOD AND CHEMICAL TOXICOLOGY

Phase I Study of Vismodegib in Children with Recurrent or Refractory Medulloblastoma: A Pediatric Brain Tumor Consortium Study

(2013) A. Gajjar et al.   CLINICAL CANCER RESEARCH

Differential cell responses to nanoparticle docetaxel and small molecule docetaxel at a sub-therapeutic dose range

(2013) Edina C. Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects

(2012) Richard A. Graham et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Polyether based amphiphiles for delivery of active components

(2012) Shilpi Gupta et al.   POLYMER

Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists

(2011) C. Metcalfe et al.   CANCER RESEARCH

Influence of formulation variables on the biodistribution of multifunctional block copolymer micelles

(2011) Humphrey Fonge et al.   JOURNAL OF CONTROLLED RELEASE

A Polymeric Nanoparticle Encapsulated Small-Molecule Inhibitor of Hedgehog Signaling (NanoHHI) Bypasses Secondary Mutational Resistance to Smoothened Antagonists

(2011) V. Chenna et al.   MOLECULAR CANCER THERAPEUTICS

Nab-paclitaxel for the treatment of breast cancer: efficacy, safety, and approval

(2011) Yutaka Yamamoto et al.   OncoTargets and Therapy

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

(2010) Katrin Knop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Doubly amphiphilic poly(2-oxazoline)s as high-capacity delivery systems for hydrophobic drugs

(2010) Robert Luxenhofer et al.   BIOMATERIALS

Cancer nanotechnology: application of nanotechnology in cancer therapy

(2010) Ranjita Misra et al.   DRUG DISCOVERY TODAY

Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes

(2009) Geneviève Gaucher et al.   JOURNAL OF CONTROLLED RELEASE

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure

(2008) Hiromichi Kimura et al.   CANCER CELL

Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma

(2008) Ulrich Schüller et al.   CANCER CELL