Formulations for children: problems and solutions

Manipulation of drugs to achieve the required dose is intrinsic to paediatric practice but is not supported by guidelines or evidence

(2013) Roberta H Richey et al.   BMC Pediatrics

The Bad Taste of Medicines: Overview of Basic Research on Bitter Taste

(2013) Julie A. Mennella et al.   CLINICAL THERAPEUTICS

Relative bioavailability of a newly developed pediatric formulation of bosentan vs. the adult formulation

(2013) Marcelo M. Gutierrez et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Acceptance of uncoated mini-tablets in young children: results from a prospective exploratory cross-over study

(2012) Natalie Spomer et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Delivery of Inhaled Drugs for Infants and Small Children: A Commentary on Present and Future Needs

(2012) James B. Fink   CLINICAL THERAPEUTICS

Comparative Fasting Bioavailability of Dispersible and Conventional Tablets of Risperidone: A Single-Dose, Randomized-Sequence, Open-Label, Two-Period Crossover Study in Healthy Male Chinese Volunteers

(2012) Mingzhu Huang et al.   CLINICAL THERAPEUTICS

A Randomized, Open-Label, 5-Period, Balanced Crossover Study to Evaluate the Relative Bioavailability of Eltrombopag Powder for Oral Suspension (PfOS) and Tablet Formulations and the Effect of a High-Calcium Meal on Eltrombopag Pharmacokinetics When Administered With or 2 Hours Before or After PfOS

(2012) Mary Beth Wire et al.   CLINICAL THERAPEUTICS

Educational Paper: Formulation-related issues in pediatric clinical pharmacology

(2012) Catherine Tuleu et al.   EUROPEAN JOURNAL OF PEDIATRICS

Direct measurement of ear canal volume in a pediatric population: Can we explain its individual variation in terms of age and body weight?

(2012) Heil Noh et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

The STEP (Safety and Toxicity of Excipients for Paediatrics) database. Part 1—A need assessment study

(2012) Smita Salunke et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A benefit/risk approach towards selecting appropriate pharmaceutical dosage forms – An application for paediatric dosage form selection

(2012) Tom Sam et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Paediatric Intramuscular Injections for Developing World Settings

(2012) Marie Clancy nee Walters et al.   Journal of Transcultural Nursing

Abstract B194: Phase 1 relative bioavailability study of a prototype oral solution (OS) formulation of the investigational Aurora A kinase (AAK) inhibitor alisertib (MLN8237) in reference to a powder-in-capsule (PIC) formulation in patients with advanced solid tumors.

(2012) G. S. Falchook et al.   MOLECULAR CANCER THERAPEUTICS

Effects of the abrupt switch from solution to modified-release granule formulation of valproate

(2011) A. Verrotti et al.   ACTA NEUROLOGICA SCANDINAVICA

Pharmacokinetic and Pharmacodynamic Characteristics of a New Pediatric Formulation of Artemether-Lumefantrine in African Children with Uncomplicated Plasmodium falciparum Malaria

(2011) Abdoulaye A. Djimdé et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics and safety of a new paediatric fixed-dose combination of zidovudine/lamivudine/nevirapine in HIV-infected children

(2011) Kulkanya Chokephaibulkit et al.   ANTIVIRAL THERAPY

Bioequivalence of dispersed stavudine: opened versus closed capsule dosing

(2011) Steve Innes et al.   ANTIVIRAL THERAPY

Prescribing for children – taste and palatability affect adherence to antibiotics: a review

(2011) Dave Baguley et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Tolerability and pharmacokinetic profile of a sunitinib powder formulation in pediatric patients with refractory solid tumors: a Children’s Oncology Group study

(2011) Steven G. DuBois et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Pharmacokinetics of Antiretroviral Drug Varies With Formulation in the Target Population of Children With HIV-1

(2011) P Kasirye et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacokinetics, Pharmacodynamics, and Comparative Bioavailability of Single, Oral 2-mg Doses of Dexamethasone Liquid and Tablet Formulations: A Randomized, Controlled, Crossover Study in Healthy Adult Volunteers

(2011) Christian Queckenberg et al.   CLINICAL THERAPEUTICS

Pharmacokinetic Comparison of Orally Disintegrating and Conventional Donepezil Formulations in Healthy Korean Male Subjects: A Single-Dose, Randomized, Open-Label, 2-Sequence, 2-Period Crossover Study

(2011) Kyoung-Ah Kim et al.   CLINICAL THERAPEUTICS

1FC1.2 A Novel Rufinamide Oral Liquid/Suspension Formulation for Lennox-Gastaut Syndrome Patients

(2011) D. Critchley   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Needle-free and microneedle drug delivery in children: A case for disease-modifying antirheumatic drugs (DMARDs)

(2011) Utpal U. Shah et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Oral Lyophylizate Formulation of Desmopressin: Superior Pharmacodynamics Compared to Tablet Due to Low Food Interaction

(2011) A. De Guchtenaere et al.   JOURNAL OF UROLOGY

Latanoprost Systemic Exposure in Pediatric and Adult Patients with Glaucoma: A Phase 1, Open-Label Study

(2011) Susan Raber et al.   OPHTHALMOLOGY

Paediatric pharmacology: Remember the excipients

(2011) Valentina Fabiano et al.   PHARMACOLOGICAL RESEARCH

Bioequivalence and pharmacokinetic comparison of two mycophenolate mofetil formulations in healthy Chinese male volunteers: An open-label, randomized-sequence, single-dose, two-way crossover study

(2010) Qian Zhang et al.   CLINICAL THERAPEUTICS

Tear Film Volume and Protein Analysis in Full-term Newborn Infants

(2010) M Esmaeelpour et al.   CORNEA

Preparation of parenteral medicines in clinical areas: how can the risks be managed - a UK perspective?

(2010) Alison M Beaney   JOURNAL OF CLINICAL NURSING

Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects

(2010) Salim Abdulla et al.   MALARIA JOURNAL

Prevalence of Eye Disease in Early Childhood and Associated FactorsFindings from the Millennium Cohort Study

(2010) Phillippa M. Cumberland et al.   OPHTHALMOLOGY

A Chewable Pediatric Fixed-dose Combination Tablet of Stavudine, Lamivudine, and Nevirapine

(2010) Nirun Vanprapar et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Safety of "inert" additives or excipients in paediatric medicines

(2009) M. C Nahata   Archives of Disease in Childhood-Fetal and Neonatal Edition

A single-dose, three-period, six-sequence crossover study comparing the bioavailability of solution, suspension, and enteric-coated tablets of magnesium valproate in healthy Mexican volunteers under fasting conditions

(2009) Gabriel Marcelín-Jiménez et al.   CLINICAL THERAPEUTICS

Pharmacokinetic and bioequivalence comparison between orally disintegrating and conventional tablet formulations of flurbiprofen: A single-dose, randomized-sequence, open-label, two-period crossover study in healthy chinese male volunteers

(2009) Yan-Mei Liu et al.   CLINICAL THERAPEUTICS

Identified Safety Risks With Splitting and Crushing Oral Medications

(2009) Susan Paparella   Journal of Emergency Nursing

Minitablets: New Modality to Deliver Medicines to Preschool-Aged Children

(2009) S. A. Thomson et al.   PEDIATRICS

The economics of pediatric formulation development for off-patent drugs

(2008) Christopher-Paul Milne et al.   CLINICAL THERAPEUTICS

Pharmacokinetic and bioequivalence comparison of a single 100-mg dose of cefteram pivoxil powder suspension and tablet formulations: a randomized-sequence, open-label, two-period crossover study in healthy chinese adult male volunteers

(2008) Jianjun Zou et al.   CLINICAL THERAPEUTICS

Bioequivalence assay between orally disintegrating and conventional tablet formulations in healthy volunteers

(2008) Yara Popst Armando et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of fixed dose combination tablets containing zidovudine and lamivudine for paediatric applications

(2008) E. Kayitare et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Barrier Function and Water-Holding and Transport Properties of Infant Stratum Corneum Are Different from Adult and Continue to Develop through the First Year of Life

(2008) Janeta Nikolovski et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transabdominal Ultrasound of Rectum as a Diagnostic Tool in Childhood Constipation

(2008) Iben Moeller Joensson et al.   JOURNAL OF UROLOGY

Pediatric Drugs-A Review of Commercially Available Oral Formulations

(2007) Robert G. Strickley et al.   JOURNAL OF PHARMACEUTICAL SCIENCES