Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

N-glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization

(2020) Sayad Md. Didarul Alam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Basal‐like and classical cells coexist in pancreatic cancer revealed by single‐cell analysis on biopsy‐derived pancreatic cancer organoids from the classical subtype

(2020) Natalia Juiz et al.   FASEB JOURNAL

Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2

(2020) Shinako Kakuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A multi-GPU biclustering algorithm for binary datasets

(2020) Aurelio Lopez-Fernandez et al.   JOURNAL OF PARALLEL AND DISTRIBUTED COMPUTING

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

(2019) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Structure and function of extracellular O-GlcNAc

(2019) Mitsutaka Ogawa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

QUBIC2: a novel and robust biclustering algorithm for analyses and interpretation of large-scale RNA-Seq data

(2019) Juan Xie et al.   BIOINFORMATICS

EBIC: an evolutionary-based parallel biclustering algorithm for pattern discovery

(2018) Patryk Orzechowski et al.   BIOINFORMATICS

Dynamic Ligand Discrimination in the Notch Signaling Pathway

(2018) Nagarajan Nandagopal et al.   CELL

Notch signaling molecule is involved in the invasion of MiaPaCa2 cells induced by CoCl2 via regulating epithelial‑mesenchymal transition

(2018) Ding‑Wei Chen et al.   Molecular Medicine Reports

Structural Divergence in O-GlcNAc Glycans Displayed on Epidermal Growth Factor-like Repeats of Mammalian Notch1

(2018) Mitsutaka Ogawa et al.   MOLECULES

Expression of Notch receptors and their ligands in pancreatic ductal adenocarcinoma

(2018) Hai‑Yan Song et al.   Experimental and Therapeutic Medicine

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Multiple Roles for O-Glycans in Notch Signalling

(2018) Shweta Varshney et al.   FEBS LETTERS

Higher notch expression implies poor survival in pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

(2018) Jianbin Ye et al.   PANCREATOLOGY

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

(2017) Shogo Sawaguchi et al.   eLife

A GPU-accelerated algorithm for biclustering analysis and detection of condition-dependent coexpression network modules

(2017) Anindya Bhattacharya et al.   Scientific Reports

Leptin-Notch signaling axis is involved in pancreatic cancer progression

(2016) Adriana Harbuzariu et al.   Oncotarget

Pancreatic cancer

(2016) Jorg Kleeff et al.   Nature Reviews Disease Primers

Efficient Gene Disruption in Cultured Primary Human Endothelial Cells by CRISPR/Cas9Novelty and Significance

(2015) Parwiz Abrahimi et al.   CIRCULATION RESEARCH

The multiple roles of epidermal growth factor repeatO-glycans in animal development

(2015) Amanda R Haltom et al.   GLYCOBIOLOGY

Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer

(2015) S Zhang et al.   ONCOGENE

CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites

(2014) Yuki Naito et al.   BIOINFORMATICS

Epithelial Notch signaling is a limiting step for pancreatic carcinogenesis

(2014) Marsha M Thomas et al.   BMC CANCER

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

(2014) Panagiotis Ntziachristos et al.   CANCER CELL

Antibodies That DetectO-Linked β-d-N-Acetylglucosamine on the Extracellular Domain of Cell Surface Glycoproteins

(2014) Yuko Tashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Outcomes in operative management of pancreatic cancer

(2014) Lindsay A. Bliss et al.   JOURNAL OF SURGICAL ONCOLOGY

The NOTCH Ligand JAGGED2 Promotes Pancreatic Cancer Metastasis Independent of NOTCH Signaling Activation

(2014) Y. Hu et al.   MOLECULAR CANCER THERAPEUTICS

Differential Effects of Tissue Culture Coating Substrates on Prostate Cancer Cell Adherence, Morphology and Behavior

(2014) Michelle S. Liberio et al.   PLoS One

Autosomal recessive Adams–Oliver syndrome caused by homozygous mutation in EOGT, encoding an EGF domain-specific O-GlcNAc transferase

(2013) Idan Cohen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Notch inhibitors for cancer treatment

(2013) Ingrid Espinoza et al.   PHARMACOLOGY & THERAPEUTICS

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Notch signaling in pancreatic cancer: oncogene or tumor suppressor?

(2013) Jacqueline L. Avila et al.   TRENDS IN MOLECULAR MEDICINE

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

(2013) Lucio Miele et al.   OncoTargets and Therapy

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

Notch1 Functions as a Tumor Suppressor in a Model of K-ras–Induced Pancreatic Ductal Adenocarcinoma

(2010) Linda Hanlon et al.   CANCER RESEARCH

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Inhibition of γ-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma

(2009) Ruben Plentz et al.   GASTROENTEROLOGY

Mutation of the fucose-specific β1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine

(2008) Sally L. Dunwoodie   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Conditional ablation of Notch signaling in pancreatic development

(2008) H. Nakhai et al.   DEVELOPMENT

O-LinkedN-Acetylglucosamine Is Present on the Extracellular Domain of Notch Receptors

(2008) Aiko Matsuura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY