Vagal Afferent Innervation of the Airways in Health and Disease

TRPM8 function and expression in vagal sensory neurons and afferent nerves innervating guinea pig esophagus

(2015) Xiaoyun Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Morphologic Characterization of Nerves in Whole-Mount Airway Biopsies

(2015) Peter W. West et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human Trachealis and Main Bronchi Smooth Muscle Are Normoresponsive in Asthma

(2015) Gijs Ijpma et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

P2X3 receptors and sensitization of autonomic reflexes

(2015) Anthony P. Ford et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Sensory input to the central nervous system from the lungs and airways: A prominent role for purinergic signalling via P2X2/3 receptors

(2015) Dirk Adriaensen et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Vagal Sensory Neuron Subtypes that Differentially Control Breathing

(2015) Rui B. Chang et al.   CELL

Effects of Aerosolized Adenosine 5′-Triphosphate in Smokers and Patients With COPD

(2015) Ozen K. Basoglu et al.   CHEST

Cough hypersensitivity syndrome: clinical measurement is the key to progress

(2015) Alyn H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

A synergistic effect of simultaneous TRPA1 and TRPV1 activations on vagal pulmonary C-fiber afferents

(2015) Yu-Jung Lin et al.   JOURNAL OF APPLIED PHYSIOLOGY

Distinct Brainstem and Forebrain Circuits Receiving Tracheal Sensory Neuron Inputs Revealed Using a Novel Conditional Anterograde Transsynaptic Viral Tracing System

(2015) A. E. McGovern et al.   JOURNAL OF NEUROSCIENCE

P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

(2015) Rayid Abdulqawi et al.   LANCET

Clinical features of the urge-to-cough in patients with chronic cough

(2015) Emma Hilton et al.   RESPIRATORY MEDICINE

Abraham Guz memorial: Still unresolved hypotheses: Lung reflexes and perceptions of breathing

(2015) Mark I.M. Noble   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Vagotomy reverses established allergen-induced airway hyperreactivity to methacholine in the mouse

(2015) M. Allen McAlexander et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

The expression profile of acid-sensing ion channel (ASIC) subunits ASIC1a, ASIC1b, ASIC2a, ASIC2b, and ASIC3 in the esophageal vagal afferent nerve subtypes

(2014) Svetlana Dusenkova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Tissue Optical Clearing, Three-Dimensional Imaging, and Computer Morphometry in Whole Mouse Lungs and Human Airways

(2014) Gregory D. Scott et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Evidence for multiple sensory circuits in the brain arising from the respiratory system: an anterograde viral tract tracing study in rodents

(2014) Alice E. McGovern et al.   Brain Structure & Function

Anatomy and Neurophysiology of Cough

(2014) Brendan J. Canning et al.   CHEST

Attentional Modulation of Reflex Cough

(2014) Thomas Janssens et al.   CHEST

Non-neuronal cholinergic airway epithelium biology

(2014) Wolfgang Kummer et al.   CURRENT OPINION IN PHARMACOLOGY

Prostaglandin D2and the role of the DP1, DP2and TP receptors in the control of airway reflex events

(2014) Sarah A. Maher et al.   EUROPEAN RESPIRATORY JOURNAL

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

(2014) A. H. Morice et al.   EUROPEAN RESPIRATORY JOURNAL

Functionally connected brain regions in the network activated during capsaicin inhalation

(2014) Michael J. Farrell et al.   HUMAN BRAIN MAPPING

Piezo2 is required for Merkel-cell mechanotransduction

(2014) Seung-Hyun Woo et al.   NATURE

Cough-related neural processing in the brain: A roadmap for cough dysfunction?

(2014) Ayaka Ando et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways

(2014) D. Trankner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Learning to breathe: Habituation of Hering–Breuer inflation reflex emerges with postnatal brainstem maturation

(2014) Mathias Dutschmann et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Breathing hot humid air induces airway irritation and cough in patients with allergic rhinitis

(2014) Mehdi Khosravi et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Selective inhibition of vagal afferent nerve pathways regulating cough using Nav 1.7 shRNA silencing in guinea pig nodose ganglia

(2013) Yukiko Muroi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Spectrum of myelinated pulmonary afferents (II)

(2013) Jun Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Brain Activity Associated with Placebo Suppression of the Urge-to-Cough in Humans

(2013) Jennifer Leech et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

High-resolution measurement of electrically-evoked vagus nerve activity in the anesthetized dog

(2013) Paul B Yoo et al.   Journal of Neural Engineering

Laryngeal and tracheal afferent nerve stimulation evokes swallowing in anaesthetized guinea pigs

(2013) Takanori Tsujimura et al.   JOURNAL OF PHYSIOLOGY-LONDON

Acid-sensing ion channels in pain and disease

(2013) John A. Wemmie et al.   NATURE REVIEWS NEUROSCIENCE

The Sensory Neurons of Touch

(2013) Victoria E. Abraira et al.   NEURON

Role of TRPA1 and TRPV1 in the ROS-dependent sensory irritation of superior laryngeal capsaicin-sensitive afferents by cigarette smoke in anesthetized rats

(2013) Bi-Yu Liu et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Chronic cough and pain: Janus faces in sensory neurobiology?

(2013) Jessica O'Neill et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Chronic cough as a neuropathic disorder

(2013) Kian Fan Chung et al.   Lancet Respiratory Medicine

TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors

(2012) Tina Marie Lieu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Bronchoconstriction Triggered by Breathing Hot Humid Air in Patients with Asthma

(2012) Don Hayes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neuroepithelial Bodies as Mechanotransducers in the Intrapulmonary Airway Epithelium

(2012) Robrecht Lembrechts et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Touch sense

(2012) Yann Roudaut et al.   Channels

Comparison of TRPA1-versus TRPV1-mediated cough in guinea pigs

(2012) Mariana Brozmanova et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Volitional control of reflex cough

(2012) Karen W. Hegland et al.   JOURNAL OF APPLIED PHYSIOLOGY

Independent transmission of convergent visceral primary afferents in the solitary tract nucleus

(2012) Stuart J. McDougall et al.   JOURNAL OF NEUROPHYSIOLOGY

A role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibres

(2012) Letitia A. Weigand et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activation of mouse bronchopulmonary C-fibres by serotonin and allergen-ovalbumin challenge

(2012) Carl Potenzieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

The neural crest- and placodes-derived afferent innervation of the mouse esophagus

(2012) L. Surdenikova et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Neural correlates coding stimulus level and perception of capsaicin-evoked urge-to-cough in humans

(2012) Michael J. Farrell et al.   NEUROIMAGE

Cough-related neurons in the nucleus tractus solitarius of decerebrate cats

(2012) A. Haji et al.   NEUROSCIENCE

Transneuronal tracing of airways-related sensory circuitry using herpes simplex virus 1, strain H129

(2012) A.E. McGovern et al.   NEUROSCIENCE

Stimulus response latency of cough and expiration reflex depends on breathing in the rabbit

(2012) S. Varechova et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Transient receptor potential channels mediate the tussive response to prostaglandin E2and bradykinin

(2012) Megan Grace et al.   THORAX

Brainstem respiratory networks: building blocks and microcircuits

(2012) Jeffrey C. Smith et al.   TRENDS IN NEUROSCIENCES

Neurotrophin and GDNF family ligand receptor expression in vagal sensory nerve subtypes innervating the adult guinea pig respiratory tract

(2011) TinaMarie Lieu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Understanding the Rhythm of Breathing: So Near, Yet So Far

(2011) Jack L. Feldman et al.   Annual Review of Physiology

Distinct tachykinin NK1receptor function in primate nucleus tractus solitarius neurons is dysregulated after second-hand tobacco smoke exposure

(2011) Shin-ichi Sekizawa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Expression of mechanogated two-pore domain potassium channels in mouse lungs: special reference to mechanosensory airway receptors

(2011) Robrecht Lembrechts et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Investigation of the Neural Control of Cough and Cough Suppression in Humans Using Functional Brain Imaging

(2011) S. B. Mazzone et al.   JOURNAL OF NEUROSCIENCE

Selective silencing of NaV1.7 decreases excitability and conduction in vagal sensory neurons

(2011) Yukiko Muroi et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPV1 Marks Synaptic Segregation of Multiple Convergent Afferents at the Rat Medial Solitary Tract Nucleus

(2011) James H. Peters et al.   PLoS One

Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways

(2011) F. D'Autreaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitivity of bronchopulmonary receptors to cold and heat mediated by transient receptor potential cation channel subtypes in an ex vivo rat lung preparation

(2011) Yun Zhou et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Sensing pulmonary oxidative stress by lung vagal afferents

(2011) Thomas E. Taylor-Clark et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Regulation of acid signaling in rat pulmonary sensory neurons by protease-activated receptor-2

(2010) Qihai Gu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Innervation of tracheal parasympathetic ganglia by esophageal cholinergic neurons: evidence from anatomic and functional studies in guinea pigs

(2010) Stuart B. Mazzone et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Encoding of the cough reflex in anesthetized guinea pigs

(2010) Brendan J. Canning et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Extracellular Adenosine Triphosphate and Chronic Obstructive Pulmonary Disease

(2010) Marek Lommatzsch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An essential component to brainstem cough gating identified in anesthetized guinea pigs

(2010) Brendan J. Canning et al.   FASEB JOURNAL

Sympathetic nerve-dependent regulation of mucosal vascular tone modifies airway smooth muscle reactivity

(2010) Stuart B. Mazzone et al.   JOURNAL OF APPLIED PHYSIOLOGY

Transgene expression and effective gene silencing in vagal afferent neuronsin vivousing recombinant adeno-associated virus vectors

(2010) M. Kollarik et al.   JOURNAL OF PHYSIOLOGY-LONDON

Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs

(2010) Christina Nassenstein et al.   JOURNAL OF PHYSIOLOGY-LONDON

Thrombin and trypsin directly activate vagal C-fibres in mouse lung via protease-activated receptor-1

(2010) Kevin Kwong et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tiotropium Bromide Step-Up Therapy for Adults with Uncontrolled Asthma

(2010) Stephen P. Peters et al.   NEW ENGLAND JOURNAL OF MEDICINE

Blockade of airway sensory nerves and dyspnea in humans

(2010) Nausherwan K. Burki et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Effect of viral upper respiratory tract infection on the urge-to-cough sensation

(2010) Peter V. Dicpinigaitis et al.   RESPIRATORY MEDICINE

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Characterization of the Vagal Motor Neurons Projecting to the Guinea Pig Airways and Esophagus

(2010) Alice E. McGovern et al.   Frontiers in Neurology

Mechanisms of eosinophil major basic protein-induced hyperexcitability of vagal pulmonary chemosensitive neurons

(2009) Qihai Gu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TRPA1 Agonists Evoke Coughing in Guinea Pig and Human Volunteers

(2009) Mark A. Birrell et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prostaglandin E2Mediates Cough via the EP3Receptor

(2009) Sarah A. Maher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cardiovascular and baroreceptor functions of the paratrigeminal nucleus for pressor effects in non-anaesthetized rats

(2009) L.O. Sousa et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Discharge rate profiles of paratrigeminal nucleus neurons throughout a pressor event in non-anaesthetized rats

(2009) L.O. Sousa et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents

(2009) E Andrè et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of protease-activated receptor 2 activation on single TRPV1 channel activities in rat vagal pulmonary sensory neurons

(2009) Qihai Gu et al.   EXPERIMENTAL PHYSIOLOGY

Selective Expression of a Sodium Pump Isozyme by Cough Receptors and Evidence for Its Essential Role in Regulating Cough

(2009) S. B. Mazzone et al.   JOURNAL OF NEUROSCIENCE

Convergence of Cranial Visceral Afferents within the Solitary Tract Nucleus

(2009) S. J. McDougall et al.   JOURNAL OF NEUROSCIENCE

Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels

(2009) Thomas E. Taylor-Clark et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prostanoids and the Cough Reflex

(2009) Sarah A. Maher et al.   LUNG

Nitrooleic Acid, an Endogenous Product of Nitrative Stress, Activates Nociceptive Sensory Nerves via the Direct Activation of TRPA1

(2009) T. E. Taylor-Clark et al.   MOLECULAR PHARMACOLOGY

Effects of cervical vagus nerve stimulation on amygdala-evoked responses of the medial prefrontal cortex neurons in rat

(2009) Olga Lyubashina et al.   NEUROSCIENCE RESEARCH

Effect of increasing temperature on TRPV1-mediated responses in isolated rat pulmonary sensory neurons

(2008) Dan Ni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

P2X2 receptors differentiate placodal vs. neural crest C-fiber phenotypes innervating guinea pig lungs and esophagus

(2008) Kevin Kwong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Differential effects of airway afferent nerve subtypes on cough and respiration in anesthetized guinea pigs

(2008) Yang-Ling Chou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Transient Receptor Potential Ankyrin 1 Mediates Toluene Diisocyanate–Evoked Respiratory Irritation

(2008) Thomas E. Taylor-Clark et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A Rat Model of Chronic Gastric Sensorimotor Dysfunction Resulting From Transient Neonatal Gastric Irritation

(2008) Lian–Sheng Liu et al.   GASTROENTEROLOGY

Neurochemical pattern of the complex innervation of neuroepithelial bodies in mouse lungs

(2008) Inge Brouns et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Adenosine induces a cholinergic tracheal reflex contraction in guinea pigs in vivo via an adenosine A1 receptor-dependent mechanism

(2008) Sandra M. Reynolds et al.   JOURNAL OF APPLIED PHYSIOLOGY

Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat

(2008) Guangfan Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Voltage-gated sodium channels in nociceptiveversusnon-nociceptive nodose vagal sensory neurons innervating guinea pig lungs

(2008) Kevin Kwong et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs

(2008) Christina Nassenstein et al.   JOURNAL OF PHYSIOLOGY-LONDON

Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal

(2008) T. E. Taylor-Clark et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPM8 Mechanism of Autonomic Nerve Response to Cold in Respiratory Airway

(2008) Hong Xing et al.   Molecular Pain

Transient receptor potential channels: targeting pain at the source

(2008) Ardem Patapoutian et al.   NATURE REVIEWS DRUG DISCOVERY

Neurosensory mechanotransduction

(2008) Martin Chalfie   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

(2008) S. Materazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping supramedullary pathways involved in cough using functional brain imaging: Comparison with pain

(2008) Stuart B. Mazzone et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The expiration reflex from the trachea and bronchi

(2007) M. Tatar et al.   EUROPEAN RESPIRATORY JOURNAL

Calcitonin gene-related peptide affects synaptic and membrane properties of bronchial parasympathetic neurons

(2007) Radhika Kajekar et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Brainstem circuitry of tracheal–bronchial cough: c-fos study in anesthetized cats

(2007) Jan Jakus et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY