Akebia saponin E, as a novel PIKfyve inhibitor, induces lysosome-associated cytoplasmic vacuolation to inhibit proliferation of hepatocellular carcinoma cells

Lysosomal Fusion: An Efficient Mechanism Increasing Their Sequestration Capacity for Weak Base Drugs without Apparent Lysosomal Biogenesis

(2020) Nikola Skoupa et al.   Biomolecules

Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma

(2020) Christa Buechler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis

(2019) Gaurav Sharma et al.   Autophagy

TFEB mediates immune evasion and resistance to mTOR inhibition of renal cell carcinoma via induction of PD-L1

(2019) Cai Zhang et al.   CLINICAL CANCER RESEARCH

Small-molecule compounds target paraptosis to improve cancer therapy

(2019) Yujia Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Identification of PIKfyve kinase as a target in multiple myeloma

(2019) Cecilia Bonolo De Campos et al.   HAEMATOLOGICA

Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations

(2019) Ognian C. Ikonomov et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Molecular targets and anti-cancer potential of escin

(2018) Dorothy H.J. Cheong et al.   CANCER LETTERS

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

(2018) Christopher H. Choy et al.   JOURNAL OF CELL SCIENCE

Increased B3GALNT2 in hepatocellular carcinoma promotes macrophage recruitment via reducing acetoacetate secretion and elevating MIF activity

(2018) Tianxiao Yang et al.   Journal of Hematology & Oncology

Statin use and the risk of hepatocellular carcinoma in patients at high risk: A nationwide nested case-control study

(2018) Gyuri Kim et al.   JOURNAL OF HEPATOLOGY

PIKfyve regulates melanosome biogenesis

(2018) Marc C. Liggins et al.   PLoS Genetics

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Activation of LXRɑ/β by cholesterol in malignant ascites promotes chemoresistance in ovarian cancer

(2018) Soochi Kim et al.   BMC CANCER

Akebia trifoliata (Thunb.) Koidz Seed Extract Inhibits Human Hepatocellular Carcinoma Cell migration and invasion in vitro

(2018) Wen-Li Lu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anticancer effects of ginsenoside Rg3 (Review)

(2017) Mengyao Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

NOX2-Mediated TFEB Activation and Vacuolization Regulate Lysosome-Associated Cell Death Induced by Gypenoside L, a Saponin Isolated from Gynostemma pentaphyllum

(2017) Kai Zheng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Decreased expression of STING predicts poor prognosis in patients with gastric cancer

(2017) Shushu Song et al.   Scientific Reports

Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency

(2016) Lauren M. Compton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

PIKfyve inhibition increases exosome release and induces secretory autophagy

(2016) Nina Pettersen Hessvik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lysosomes as mediators of drug resistance in cancer

(2016) Benny Zhitomirsky et al.   DRUG RESISTANCE UPDATES

The Fab1/PIKfyve Phosphoinositide Phosphate Kinase Is Not Necessary to Maintain the pH of Lysosomes and of the Yeast Vacuole

(2015) Cheuk Y. Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI(5)P Regulates Autophagosome Biogenesis

(2015) Mariella Vicinanza et al.   MOLECULAR CELL

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance

(2015) Benny Zhitomirsky et al.   Oncotarget

Endoplasmic reticulum vacuolation and unfolded protein response leading to paraptosis like cell death in cyclosporine A treated cancer cervix cells is mediated by cyclophilin B inhibition

(2014) Babul Moni Ram et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Entosis, a key player in cancer cell competition

(2014) Guido Kroemer et al.   CELL RESEARCH

The signaling lipid PI(3,5)P2 stabilizes V1–Vo sector interactions and activates the V-ATPase

(2014) Sheena Claire Li et al.   MOLECULAR BIOLOGY OF THE CELL

P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration

(2013) Tetsuo Yamagishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

Cytoplasmic vacuolization during exposure to drugs and other substances

(2012) Toshihiko Aki et al.   CELL BIOLOGY AND TOXICOLOGY

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Oncosis: An important non-apoptotic mode of cell death

(2012) Priya Weerasinghe et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway

(2012) MEIJUAN CHEN et al.   ONCOLOGY REPORTS

Lysosomal Sequestration of Sunitinib: A Novel Mechanism of Drug Resistance

(2011) K. J. Gotink et al.   CLINICAL CANCER RESEARCH

Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function

(2009) Stephen K. Dove et al.   BIOCHEMICAL JOURNAL

PIKfyve Regulation of Endosome-Linked Pathways

(2009) Jane de Lartigue et al.   TRAFFIC

Apoptosis-inducing effect of Akebia saponin D from the roots of Dipsacus asper Wall in U937 cells

(2008) Seung-Il Jeong et al.   ARCHIVES OF PHARMACAL RESEARCH

Timosaponin A-III Induces Autophagy Preceding Mitochondria-Mediated Apoptosis in HeLa Cancer Cells

(2008) L.-K. Sy et al.   CANCER RESEARCH

Active Ras Triggers Death in Glioblastoma Cells through Hyperstimulation of Macropinocytosis

(2008) J. H. Overmeyer et al.   MOLECULAR CANCER RESEARCH

Regulation of the V-ATPase along the Endocytic Pathway Occurs through Reversible Subunit Association and Membrane Localization

(2008) Céline Lafourcade et al.   PLoS One