Vitamin D Signaling in Gastro-Rheumatology: From Immuno-Modulation to Potential Clinical Applications

Cathelicidin Mediates a Protective Role of Vitamin D in Ulcerative Colitis and Human Colonic Epithelial Cells

(2020) John Gubatan et al.   INFLAMMATORY BOWEL DISEASES

Key Vitamin D Target Genes with Functions in the Immune System

(2020) Oona Koivisto et al.   Nutrients

Pathophysiological Role and Therapeutic Implications of Vitamin D in Autoimmunity: Focus on Chronic Autoimmune Diseases

(2020) Mattia Bellan et al.   Nutrients

Seasonal changes of circulating 25-hydroxyvitamin D correlate with the lower gut microbiome composition in inflammatory bowel disease patients

(2020) Katarina Soltys et al.   Scientific Reports

Paradoxical gastrointestinal effects of interleukin-17 blockers

(2020) Marine Fauny et al.   ANNALS OF THE RHEUMATIC DISEASES

The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis

(2020) Hiroyuki Tsukazaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Update on Vitamin D Metabolism

(2020) Federica Saponaro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Why do so many trials of vitamin D supplementation fail?

(2020) Barbara J Boucher   Endocrine Connections

Efficacy of Oral Vitamin Supplementation in Inflammatory Rheumatic Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2020) Yann Nguyen et al.   Nutrients

Impact of Mediterranean Diet on Disease Activity and Gut Microbiota Composition of Rheumatoid Arthritis Patients

(2020) Andrea Picchianti Diamanti et al.   Microorganisms

Paneth Cell Alertness to Pathogens Maintained by Vitamin D Receptors

(2020) Rong Lu et al.   GASTROENTEROLOGY

Environmental Risk Factors for Inflammatory Bowel Diseases: an Umbrella Review of Meta-analyses

(2019) Daniele Piovani et al.   GASTROENTEROLOGY

Vitamin D differentially regulates colon stem cells in patient‐derived normal and tumor organoids

(2019) Asunción Fernández‐Barral et al.   FEBS Journal

Systematic review with meta-analysis: association of vitamin D status with clinical outcomes in adult patients with inflammatory bowel disease

(2019) John Gubatan et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The relationship of serum vitamin D receptor levels with disease activity and clinical parameters in patients with ankylosing spondylitis

(2019) Turgut Kültür   Turkish Journal of Physical Medicine and Rehabilitation

The Effect of Vitamin D on Intestinal Inflammation and Faecal Microbiota in Patients with Ulcerative Colitis

(2018) Mayur Garg et al.   Journal of Crohns & Colitis

Vitamin D administration leads to a shift of the intestinal bacterial composition in Crohn's disease patients, but not in healthy controls

(2018) Holger Schäffler et al.   Journal of Digestive Diseases

Infectious Agents and Inflammation: The Role of Microbiota in Autoimmune Arthritis

(2018) Andrea Picchianti-Diamanti et al.   Frontiers in Microbiology

The Gut Microbiota Regulates Endocrine Vitamin D Metabolism through Fibroblast Growth Factor 23

(2018) Stephanie A. Bora et al.   Frontiers in Immunology

Bacterial steroid hydroxylases: enzyme classes, their functions and comparison of their catalytic mechanisms

(2018) Maciej Szaleniec et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

On cell death in the intestinal epithelium and its impact on gut homeostasis

(2018) J. Magarian Blander   CURRENT OPINION IN GASTROENTEROLOGY

Analysis of Gut Microbiota in Rheumatoid Arthritis Patients: Disease-Related Dysbiosis and Modifications Induced by Etanercept

(2018) Andrea Picchianti-Diamanti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vitamin D and the gut microbiome: a systematic review of in vivo studies

(2018) Mary Waterhouse et al.   EUROPEAN JOURNAL OF NUTRITION

Lack of Vitamin D Receptor Leads to Hyperfunction of Claudin-2 in Intestinal Inflammatory Responses

(2018) Yong-guo Zhang et al.   INFLAMMATORY BOWEL DISEASES

Efficacy of vitamin D in treatment of inflammatory bowel disease

(2018) Jinzhong Li et al.   MEDICINE

1,25-dihydroxyvitamin D3 -induced dendritic cells suppress experimental autoimmune encephalomyelitis by increasing proportions of the regulatory lymphocytes and reducing T helper type 1 and type 17 cells

(2017) Zhongxiang Xie et al.   IMMUNOLOGY

Inhibition of Autophagic Degradation Process Contributes to Claudin-2 Expression Increase and Epithelial Tight Junction Dysfunction in TNF-α Treated Cell Monolayers

(2017) Cong Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights

(2017) J. Wesley Pike et al.   JOURNAL OF CLINICAL INVESTIGATION

Ankylosing Spondylitis and Axial Spondyloarthritis in Patients With Long-term Inflammatory Bowel Disease: Results From 20 Years of Follow-up in the IBSEN Study

(2017) Alvilde M Ossum et al.   Journal of Crohns & Colitis

Colonic transcriptional response to 1α,25(OH) 2 vitamin D 3 in African- and European-Americans

(2017) Dereck Alleyne et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Association between Vitamin D Receptor Polymorphism and Serum Vitamin D Levels in Children with Low-Energy Fractures

(2017) Michal Karpiński et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Gut microbiota interactions with the immunomodulatory role of vitamin D in normal individuals

(2017) Renata V. Luthold et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Anxiety, Depression, and the Microbiome: A Role for Gut Peptides

(2017) Gilliard Lach et al.   Neurotherapeutics

Vitamin D in autoimmune rheumatic diseases: A view inside gender differences

(2017) Massimiliano Vasile et al.   PHARMACOLOGICAL RESEARCH

Cholecalciferol decreases inflammation and improves vitamin D regulatory enzymes in lymphocytes in the uremic environment: A randomized controlled pilot trial

(2017) José Tarcisio G. Carvalho et al.   PLoS One

The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention

(2017) Michael F. Holick   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Vitamin D Deficiency in Axial Spondyloarthritis is Associated With Higher Disease Activity

(2017) Sizheng Zhao   Archives of Rheumatology

Vitamin D and immunomodulation in early rheumatoid arthritis: A randomized double-blind placebo-controlled study

(2017) Ilaria Buondonno et al.   PLoS One

Association of Vitamin D Level With Clinical Status in Inflammatory Bowel Disease: A 5-Year Longitudinal Study

(2016) Toufic A Kabbani et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Comparative effect of 25(OH)D3 and 1,25(OH)2D3 on Th17 cell differentiation

(2016) Lama Fawaz et al.   CLINICAL IMMUNOLOGY

Vitamin D deficiency in patients with either rheumatic diseases or inflammatory bowel diseases on biologic therapy

(2016) Vincenzo Bruzzese et al.   Internal and Emergency Medicine

Microbiota and chronic inflammatory arthritis: an interwoven link

(2016) Andrea Picchianti Diamanti et al.   Journal of Translational Medicine

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

(2016) Jun Wang et al.   NATURE GENETICS

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

(2016) David Ellinghaus et al.   NATURE GENETICS

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

(2016) David R Withers et al.   NATURE MEDICINE

The vitamin D status in ankylosing spondylitis in relation to intestinal inflammation, disease activity, and bone health: a cross-sectional study

(2016) E. Klingberg et al.   OSTEOPOROSIS INTERNATIONAL

Sexual Dimorphism in the Th17 Signature of Ankylosing Spondylitis

(2016) Eric Gracey et al.   Arthritis & Rheumatology

Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models

(2016) Danmei Su et al.   Frontiers in Physiology

Regulatory T Cells and Vitamin D Status in Children with Chronic Autoimmune Thyroiditis

(2016) Zeynep Şıklar et al.   Journal of Clinical Research in Pediatric Endocrinology

HLA-B27

(2015) Paul Bowness   Annual Review of Immunology

Cholecalciferol supplementation improves suppressive capacity of regulatory T-cells in young patients with new-onset type 1 diabetes mellitus — A randomized clinical trial

(2015) Gerlies Treiber et al.   CLINICAL IMMUNOLOGY

Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract

(2015) Mina Bashir et al.   EUROPEAN JOURNAL OF NUTRITION

Cell death at the intestinal epithelial front line

(2015) Maria Eugenia Delgado et al.   FEBS Journal

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

(2015) Jacob S. Lee et al.   IMMUNITY

Association Between Inflammatory Bowel Disease and Vitamin D Deficiency

(2015) Rita Del Pinto et al.   INFLAMMATORY BOWEL DISEASES

Vitamin D Deficiency Predisposes to Adherent-invasive Escherichia coli-induced Barrier Dysfunction and Experimental Colonic Injury

(2015) Amit Assa et al.   INFLAMMATORY BOWEL DISEASES

Autophagy Enhances Intestinal Epithelial Tight Junction Barrier Function by Targeting Claudin-2 Protein Degradation

(2015) Prashant K. Nighot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The epidemiology of extra-articular manifestations in ankylosing spondylitis: a population-based matched cohort study

(2014) Carmen Stolwijk et al.   ANNALS OF THE RHEUMATIC DISEASES

The Vitamin D Receptor (VDR) Is Expressed in Skeletal Muscle of Male Mice and Modulates 25-Hydroxyvitamin D (25OHD) Uptake in Myofibers

(2014) Christian M. Girgis et al.   ENDOCRINOLOGY

Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis

(2014) Shaoping Wu et al.   GUT

Protective Effect of 1,25-Dihydroxyvitamin D3 on Lipopolysaccharide-Induced Intestinal Epithelial Tight Junction Injury in Caco-2 Cell Monolayers

(2014) Shan-wen Chen et al.   INFLAMMATION

IBD Candidate Genes and Intestinal Barrier Regulation

(2014) Declan F. McCole   INFLAMMATORY BOWEL DISEASES

Intracellular distribution of the vitamin D receptor in the brain: Comparison with classic target tissues and redistribution with development

(2014) D.W. Eyles et al.   NEUROSCIENCE

HLA-B27 and Human β2-Microglobulin Affect the Gut Microbiota of Transgenic Rats

(2014) Phoebe Lin et al.   PLoS One

Systematic review of association between vitamin D levels and susceptibility and disease activity of ankylosing spondylitis

(2014) S. Zhao et al.   RHEUMATOLOGY

Impact of Diet on Human Intestinal Microbiota and Health

(2014) Anne Salonen et al.   Annual Review of Food Science and Technology

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

(2013) Ning Ding et al.   CELL

Oral vitamin D increases the frequencies of CD38+human B cells and ameliorates IL-17-producing T cells

(2013) Gennadiy Drozdenko et al.   EXPERIMENTAL DERMATOLOGY

Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease

(2013) Ashwin N. Ananthakrishnan et al.   INFLAMMATORY BOWEL DISEASES

Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis

(2013) Weicheng Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Vitamin D Regulates the Gut Microbiome and Protects Mice from Dextran Sodium Sulfate–Induced Colitis

(2013) Jot Hui Ooi et al.   JOURNAL OF NUTRITION

Vitamin D and Crohn’s Disease in the Adult Patient

(2013) Abigail Basson   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection

(2013) John R Grainger et al.   NATURE MEDICINE

Influence of Cholecalciferol Supplementation in Hemodialysis Patients on Monocyte Subsets: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2013) Eric Seibert et al.   NEPHRON CLINICAL PRACTICE

Where is the vitamin D receptor?

(2012) Yongji Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Protective role of 1,25(OH)2vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice

(2012) Hongwei Zhao et al.   BMC GASTROENTEROLOGY

A comprehensive summary of LL-37, the factotum human cathelicidin peptide

(2012) Dieter Vandamme et al.   CELLULAR IMMUNOLOGY

1,25-Dihydroxyvitamin D3 curtails the inflammatory and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism

(2012) Hannelie Korf et al.   IMMUNOBIOLOGY

Associations Between Vitamin D Receptor Polymorphisms and Susceptibility to Ulcerative Colitis and Crohnʼs Disease

(2012) Le-Ning Xue et al.   INFLAMMATORY BOWEL DISEASES

The gut microbiota in IBD

(2012) Chaysavanh Manichanh et al.   Nature Reviews Gastroenterology & Hepatology

Time for a gut check: Evidence for the hypothesis that HLA-B27 predisposes to ankylosing spondylitis by altering the microbiome

(2011) James T. Rosenbaum et al.   ARTHRITIS AND RHEUMATISM

Interleukin-22 and interleukin-22-producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis

(2011) Francesco Ciccia et al.   ARTHRITIS AND RHEUMATISM

Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline

(2011) Michael F. Holick et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

1,25-Dihydroxyvitamin D3 Ameliorates Th17 Autoimmunity via Transcriptional Modulation of Interleukin-17A

(2011) S. Joshi et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Vitamin D3 treatment of Crohn’s disease patients increases stimulated T cell IL-6 production and proliferation

(2010) M. Bendix-Struve et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Clinical trial: vitamin D3 treatment in Crohn’s disease - a randomized double-blind placebo-controlled study

(2010) S. P. Jørgensen et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Vitamin D Receptor Negatively Regulates Bacterial-Stimulated NF-κB Activity in Intestine

(2010) Shaoping Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25-Dihydroxyvitamin D3

(2010) J. Wesley Pike et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Lineage-specific Effects of 1,25-Dihydroxyvitamin D3on the Development of Effector CD4 T Cells

(2010) Matthew T. Palmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity

(2010) Diane L. Kamen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Overexpression of interleukin-23, but not interleukin-17, as an immunologic signature of subclinical intestinal inflammation in ankylosing spondylitis

(2009) Francesco Ciccia et al.   ARTHRITIS AND RHEUMATISM

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease

(2009) Tian-Tian Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Convergence of IL-1β and VDR Activation Pathways in Human TLR2/1-Induced Antimicrobial Responses

(2009) Philip T. Liu et al.   PLoS One