标题
Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 4, Pages 1742
出版商
MDPI AG
发表日期
2021-02-10
DOI
10.3390/ijms22041742
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Role of Inflammation in the Pathogenesis of Osteoarthritis
- (2020) Yoke Yue Chow et al. MEDIATORS OF INFLAMMATION
- Structure and Function of Human Matrix Metalloproteinases
- (2020) Helena Laronha et al. Cells
- Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
- (2020) Doo Ri Park et al. Nature Communications
- Randomized, Double‐Blind, Placebo‐Controlled Trial of Intra‐articular CNTX ‐4975 ( trans‐ capsaicin) for Pain Associated With Osteoarthritis of the Knee
- (2019) Randall M. Stevens et al. Arthritis & Rheumatology
- Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key
- (2019) Paola Castrogiovanni et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Contribution of Infrapatellar Fat Pad and Synovial Membrane to Knee Osteoarthritis Pain
- (2019) Elisa Belluzzi et al. Biomed Research International
- MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes
- (2019) Zafar Rasheed et al. Scientific Reports
- Runx2 plays a central role in Osteoarthritis development
- (2019) Di Chen et al. Journal of Orthopaedic Translation
- Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics
- (2018) Nazir M. Khan et al. PHARMACOLOGICAL RESEARCH
- CGRP blockade by galcanezumab was not associated with reductions in signs and symptoms of knee osteoarthritis in a randomized clinical trial
- (2018) Y. Jin et al. OSTEOARTHRITIS AND CARTILAGE
- Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis
- (2018) Margreet Kloppenburg et al. ANNALS OF THE RHEUMATIC DISEASES
- Effectiveness of low-dose radiation therapy on symptoms in patients with knee osteoarthritis: a randomised, double-blinded, sham-controlled trial
- (2018) Elien A M Mahler et al. ANNALS OF THE RHEUMATIC DISEASES
- Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
- (2018) Spencer L James et al. LANCET
- LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes
- (2017) Jinan Elayyan et al. FASEB JOURNAL
- Resveratrol inhibits the IL-1β-induced expression of MMP-13 and IL-6 in human articular chondrocytes via TLR4/MyD88-dependent and -independent signaling cascades
- (2017) Hailun Gu et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach
- (2017) Hiroshi Nara et al. JOURNAL OF MEDICINAL CHEMISTRY
- Downregulation of microRNA-9 increases matrix metalloproteinase-13 expression levels and facilitates osteoarthritis onset
- (2017) Hongxin Zhang et al. Molecular Medicine Reports
- Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol‑treated osteoarthritis chondrocytes via the Wnt/β‑catenin signaling pathways
- (2017) Shuan Liu et al. Experimental and Therapeutic Medicine
- LncRNA-UCA1 enhances MMP-13 expression by inhibiting miR- 204-5p in human chondrocytes
- (2017) Guodong Wang et al. Oncotarget
- DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes
- (2017) Atsushi Takahashi et al. Scientific Reports
- Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review
- (2016) Carlos J. Meheux et al. ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
- Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors
- (2016) Hiroshi Nara et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Histone deacetylase 3 suppresses Erk phosphorylation and matrix metalloproteinase (Mmp)-13 activity in chondrocytes
- (2016) Lomeli R. Carpio et al. CONNECTIVE TISSUE RESEARCH
- Monoclonal antibodies for the treatment of osteoarthritis
- (2016) Shuang Zheng et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1
- (2016) Kazuhiro Yamamoto et al. MATRIX BIOLOGY
- MicroRNA-9 regulates the development of knee osteoarthritis through the NF-kappaB1 pathway in chondrocytes
- (2016) Ronghe Gu et al. MEDICINE
- MicroRNA-320 regulates matrix metalloproteinase-13 expression in chondrogenesis and interleukin-1β-induced chondrocyte responses
- (2016) F. Meng et al. OSTEOARTHRITIS AND CARTILAGE
- The Role of MicroRNAs and Their Targets in Osteoarthritis
- (2016) Gregory R. Sondag et al. Current Rheumatology Reports
- Osteoarthritis
- (2016) Johanne Martel-Pelletier et al. Nature Reviews Disease Primers
- Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 ‘Sponge’ in Human Cartilage Degradation
- (2016) Qiang Liu et al. Scientific Reports
- Biologic basis of osteoarthritis
- (2015) Charles J. Malemud CURRENT OPINION IN RHEUMATOLOGY
- MicroRNA-16-5p Controls Development of Osteoarthritis by Targeting SMAD3 in Chondrocytes
- (2015) Lisong Li et al. CURRENT PHARMACEUTICAL DESIGN
- Potential clinical implications of recent matrix metalloproteinase inhibitor design strategies
- (2015) Sabrina Amar et al. Expert Review of Proteomics
- Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis
- (2015) Peter G. Ruminski et al. JOURNAL OF MEDICINAL CHEMISTRY
- MiR-29a and MiR-140 Protect Chondrocytes against the Anti-Proliferation and Cell Matrix Signaling Changes by IL-1β
- (2015) MOLECULES AND CELLS
- Roadmap for regulation
- (2015) Casey E. Romanoski et al. NATURE
- Expression profile of long noncoding RNAs in cartilage from knee osteoarthritis patients
- (2015) M. Fu et al. OSTEOARTHRITIS AND CARTILAGE
- Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2
- (2015) Shurei Sugita et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The alternative role of DNA methylation in splicing regulation
- (2015) Galit Lev Maor et al. TRENDS IN GENETICS
- Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-β signalling pathway
- (2015) Erfan Aref-Eshghi et al. ARTHRITIS RESEARCH & THERAPY
- MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes
- (2015) Fotini Kostopoulou et al. ARTHRITIS RESEARCH & THERAPY
- MicroRNA-602 and MicroRNA-608 Regulate Sonic Hedgehog Expression via Target Sites in the Coding Region in Human Chondrocytes
- (2015) Nahid Akhtar et al. Arthritis & Rheumatology
- Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage
- (2014) Wang Hui et al. ANNALS OF THE RHEUMATIC DISEASES
- Effect of microRNA-145 on IL-1β-induced cartilage degradation in human chondrocytes
- (2014) Bo Yang et al. FEBS LETTERS
- The Recognition of Collagen and Triple-helical Toolkit Peptides by MMP-13
- (2014) Joanna-Marie Howes et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effective knock down of matrix metalloproteinase-13 by an intra-articular injection of small interfering RNA (siRNA) in a murine surgically-induced osteoarthritis model
- (2014) Ryuichiro Akagi et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis
- (2014) Jinsoo Song et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Integrins and chondrocyte–matrix interactions in articular cartilage
- (2014) Richard F. Loeser MATRIX BIOLOGY
- Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis
- (2014) Reiji Higashiyama et al. Modern Rheumatology
- Association between adiponectin and cartilage degradation in human osteoarthritis
- (2014) P.-J. Francin et al. OSTEOARTHRITIS AND CARTILAGE
- Effective knock down of MMP13 and ADAMTS5 by intra-articular injection of small interference RNA (siRNA) in a surgically induced osteoarthritis model of mice
- (2014) H. Hoshi et al. OSTEOARTHRITIS AND CARTILAGE
- Intra-Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof-of-Concept Clinical Trial
- (2014) Chris Hyunchul Jo et al. STEM CELLS
- p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis
- (2014) Didier Philipot et al. ARTHRITIS RESEARCH & THERAPY
- Effect of osteopontin on TIMP-1 and TIMP-2 mRNA in chondrocytes of human knee osteoarthritis in vitro
- (2014) FANG-JIE ZHANG et al. Experimental and Therapeutic Medicine
- Brief Report: Stress-Inducible Nuclear Protein 1 Regulates Matrix Metalloproteinase 13 Expression in Human Articular Chondrocytes
- (2014) Raghunatha R. Yammani et al. Arthritis & Rheumatology
- MicroRNA-127-5p Regulates Matrix Metalloproteinase 13 Expression and Interleukin-1β-Induced Catabolic Effects in Human Chondrocytes
- (2013) Su Jin Park et al. ARTHRITIS AND RHEUMATISM
- MicroRNA-181b regulates articular chondrocytes differentiation and cartilage integrity
- (2013) Jinsoo Song et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Epidemiology and burden of osteoarthritis
- (2013) A. Litwic et al. BRITISH MEDICAL BULLETIN
- MicroRNA-9 regulates survival of chondroblasts and cartilage integrity by targeting protogenin
- (2013) Jinsoo Song et al. Cell Communication and Signaling
- The expression of intronic miRNAs, miR-483 and miR-483*, and their host gene, Igf2, in murine osteoarthritis cartilage
- (2013) Yuebin Qi et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites
- (2013) Ko Hashimoto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Natural RNA circles function as efficient microRNA sponges
- (2013) Thomas B. Hansen et al. NATURE
- Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes
- (2013) L.A. Vonk et al. OSTEOARTHRITIS AND CARTILAGE
- On the classification of long non-coding RNAs
- (2013) Lina Ma et al. RNA Biology
- Epigenetic Mechanisms and Non-coding RNAs in Osteoarthritis
- (2013) Matt J. Barter et al. Current Rheumatology Reports
- Long Noncoding RNA Related to Cartilage Injury Promotes Chondrocyte Extracellular Matrix Degradation in Osteoarthritis
- (2013) Qiang Liu et al. Arthritis & Rheumatology
- Development of a Neutralizing Antibody Specific for the Active Form of Matrix Metalloproteinase-13
- (2012) Shoichi Naito et al. BIOCHEMISTRY
- Inhibition Effect of Curcumin on TNF-a and MMP-13 Expression Induced by Advanced Glycation End Products in Chondrocytes
- (2012) Qingshan Yang et al. PHARMACOLOGY
- Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes
- (2011) Mona Dvir-Ginzberg et al. ARTHRITIS AND RHEUMATISM
- Selective non zinc binding inhibitors of MMP13
- (2011) Chris De Savi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes
- (2011) Makoto Hirata et al. HUMAN MOLECULAR GENETICS
- E74-like Factor 3 (ELF3) Impacts on Matrix Metalloproteinase 13 (MMP13) Transcriptional Control in Articular Chondrocytes under Proinflammatory Stress
- (2011) Miguel Otero et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery and Evaluation of a Non-Zn Chelating, Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitor for Potential Intra-articular Treatment of Osteoarthritis
- (2011) Christian Gege et al. JOURNAL OF MEDICINAL CHEMISTRY
- Genetics and epigenetics of osteoarthritis
- (2011) Louise N. Reynard et al. MATURITAS
- Anabolic/Catabolic Balance in Pathogenesis of Osteoarthritis: Identifying Molecular Targets
- (2011) Michael B. Mueller et al. PM&R
- Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice
- (2010) Lin Xu et al. ARTHRITIS AND RHEUMATISM
- MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes
- (2010) Nahid Akhtar et al. ARTHRITIS AND RHEUMATISM
- Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: Confirmation by multivariate analysis that modulation of type ii collagen and aggrecan degradation pepti
- (2010) Steven Settle et al. ARTHRITIS AND RHEUMATISM
- Retrospective Analysis of Infection Rate After Early Reoperation in Total Hip Arthroplasty
- (2010) Hussein Darwiche et al. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
- Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases
- (2010) Takayuki Shiomi et al. PATHOLOGY INTERNATIONAL
- Is obesity a risk factor for progressive radiographic knee osteoarthritis?
- (2009) J. Niu et al. ARTHRITIS AND RHEUMATISM
- Matrix metalloproteinase 13âdeficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development
- (2009) C. B. Little et al. ARTHRITIS AND RHEUMATISM
- Expression of MicroRNA-146a in osteoarthritis cartilage
- (2009) Keiichiro Yamasaki et al. ARTHRITIS AND RHEUMATISM
- To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition
- (2009) Jennifer A. Jacobsen et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
- (2009) Mark E. Schnute et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes
- (2009) Ginette Tardif et al. BMC MUSCULOSKELETAL DISORDERS
- A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes
- (2009) Sohee Hong et al. FASEB JOURNAL
- Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice
- (2009) E. N. Blaney Davidson et al. JOURNAL OF IMMUNOLOGY
- Lymphoid Enhancer Binding Factor 1 Regulates Transcription through Gene Looping
- (2009) K. Yun et al. JOURNAL OF IMMUNOLOGY
- N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis
- (2009) Elisa Nuti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13†
- (2009) Lauren G. Monovich et al. JOURNAL OF MEDICINAL CHEMISTRY
- Long non-coding RNAs: insights into functions
- (2009) Tim R. Mercer et al. NATURE REVIEWS GENETICS
- Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-α and matrix metalloproteinase-13 in human chondrocytes
- (2009) Zafar Rasheed et al. ARTHRITIS RESEARCH & THERAPY
- Differential upregulation of the three transforming growth factor beta isoforms in human osteoarthritic cartilage
- (2008) M Pombo-Suarez et al. ANNALS OF THE RHEUMATIC DISEASES
- Structural Bases for Substrate and Inhibitor Recognition by Matrix Metalloproteinases
- (2008) Loretta Aureli et al. CURRENT MEDICINAL CHEMISTRY
- Joint Diseases and Matrix Metalloproteinases: A Role for MMP-13
- (2008) Hironari Takaishi et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Role of the hemopexin domain of matrix metalloproteinases in cell migration
- (2008) Antoine Dufour et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Quinazolinones and Pyrido[3,4-d]pyrimidin-4-ones as Orally Active and Specific Matrix Metalloproteinase-13 Inhibitors for the Treatment of Osteoarthritis
- (2008) Jie Jack Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways
- (2008) M. Zhang et al. OSTEOARTHRITIS AND CARTILAGE
- Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation
- (2008) Kelvin S. C. Cheung et al. RHEUMATOLOGY INTERNATIONAL
- Deadenylation is a widespread effect of miRNA regulation
- (2008) A. Eulalio et al. RNA
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