LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes

Acetylation reduces SOX9 nuclear entryand ACANgene transactivation in human chondrocytes

(2016) Michal Bar Oz et al.   AGING CELL

The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis

(2016) Mona Dvir-Ginzberg et al.   Current Rheumatology Reports

Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2α

(2015) Wuyin Li et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells

(2014) Wei Jiang et al.   Scientific Reports

Cartilage Repair Using Human Embryonic Stem Cell-Derived Chondroprogenitors

(2014) Aixin Cheng et al.   Stem Cells Translational Medicine

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

(2013) Petra Simic et al.   EMBO Molecular Medicine

Aggrecanase and Aggrecan Degradation in Osteoarthritis: A Review

(2013) K Huang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway

(2012) DaWu Wang et al.   AGE

Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice

(2012) Odile Gabay et al.   ANNALS OF THE RHEUMATIC DISEASES

A Wnt/β-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes

(2012) Bin Ma et al.   ARTHRITIS AND RHEUMATISM

SIRT1 – An Anti-Inflammatory Pathway at the Crossroads Between Metabolic Disease and Atherosclerosis

(2012) Stephan Winnik et al.   Current Vascular Pharmacology

The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes

(2012) Takehiko Matsushita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway

(2012) Hyun-Dae Lim et al.   JOURNAL OF PINEAL RESEARCH

Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes

(2011) Mona Dvir-Ginzberg et al.   ARTHRITIS AND RHEUMATISM

75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes

(2011) Hanna Oppenheimer et al.   ARTHRITIS AND RHEUMATISM

Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity

(2011) Ming Lei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of Gsk3β in cartilage induces osteoarthritic features through activation of the canonical Wnt signaling pathway

(2011) R.L. Miclea et al.   OSTEOARTHRITIS AND CARTILAGE

SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway

(2010) Viktoria Gagarina et al.   ARTHRITIS AND RHEUMATISM

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

(2010) Norifumi Fujita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Directed differentiation of human embryonic stem cells toward chondrocytes

(2010) Rachel A Oldershaw et al.   NATURE BIOTECHNOLOGY

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

(2009) Takeshi Yoshizaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SIRT1 regulation of apoptosis of human chondrocytes

(2009) Koji Takayama et al.   ARTHRITIS AND RHEUMATISM

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9

(2009) Yuji Nakamaru et al.   FASEB JOURNAL

Lymphoid Enhancer Binding Factor 1 Regulates Transcription through Gene Looping

(2009) K. Yun et al.   JOURNAL OF IMMUNOLOGY

Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase

(2008) Mona Dvir-Ginzberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt–β-catenin signaling in the pathogenesis of osteoarthritis

(2008) Maripat Corr   Nature clinical practice. Rheumatology