Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History

Dulaglutide exerts beneficial anti atherosclerotic effects in ApoE knockout mice with diabetes: the earlier, the better

(2021) Junpei Sanada et al.   Scientific Reports

Semaglutide (SUSTAIN and PIONEER) reduces cardiovascular events in type 2 diabetes across varying cardiovascular risk

(2020) Mansoor Husain et al.   DIABETES OBESITY & METABOLISM

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Characteristics and Outcomes of Patients With Diabetes and COVID-19 in Association With Glucose-Lowering Medication

(2020) Yuchen Chen et al.   DIABETES CARE

Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study

(2020) Bertrand Cariou et al.   DIABETOLOGIA

Metformin users with diabetes and individuals without diabetes were at lower risk of overall cancer incidence than metformin non-users with diabetes based on the Korean NHIS-HEALS cohort

(2020) Ye-Seul Kim et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

COVID-19 and Diabetes Mellitus: May Old Anti-diabetic Agents Become the New Philosopher’s Stone?

(2020) Theano Penlioglou et al.   Diabetes Therapy

Enhanced Release of Glucose Into the Intraluminal Space of the Intestine Associated With Metformin Treatment as Revealed by [18F]Fluorodeoxyglucose PET-MRI

(2020) Yasuko Morita et al.   DIABETES CARE

Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes

(2020) Xu Cheng et al.   Cell Metabolism

Metformin usage and the risk of colorectal cancer: a national cohort study

(2020) Jae-woo Lee et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Relationships are between metformin use and survival in pancreatic cancer patients concurrent with diabetes

(2020) Yu-Qi Shi et al.   MEDICINE

Dose‐dependent accumulation of glucose in the intestinal wall and lumen induced by metformin as revealed by 18 F‐labelled fluorodeoxyglucose positron emission tomography‐ MRI

(2020) Jun Ito et al.   DIABETES OBESITY & METABOLISM

Notable Underlying Mechanism for Pancreatic β-Cell Dysfunction and Atherosclerosis: Pleiotropic Roles of Incretin and Insulin Signaling

(2020) Hideaki Kaneto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Efficacy and Cardiovascular Safety of GLP-1 Receptor Analogues

(2020) Anoop Mohamed Iqbal et al.   Current Drug Safety

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

(2019) Satish Patel et al.   Cell Metabolism

Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study

(2019) John W. Apolzan et al.   ANNALS OF INTERNAL MEDICINE

Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice

(2019) Atsushi Obata et al.   DIABETOLOGIA

Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial

(2019) Hertzel C Gerstein et al.   LANCET

Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

(2019) Mansoor Husain et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials

(2019) Søren L Kristensen et al.   Lancet Diabetes & Endocrinology

Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes

(2019) Joshua Demb et al.   Clinical and Translational Gastroenterology

Endothelial GLP-1 (Glucagon-Like Peptide-1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice With Experimental Arterial Hypertension

(2019) Johanna Helmstädter et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GDF15 mediates the effects of metformin on body weight and energy balance

(2019) Anthony P. Coll et al.   NATURE

Protective effects of the SGLT2 inhibitor luseogliflozin on pancreatic β-cells in db/db mice: The earlier and longer, the better

(2018) Tomohiko Kimura et al.   DIABETES OBESITY & METABOLISM

Trends in cause-specific mortality among adults with and without diagnosed diabetes in the USA: an epidemiological analysis of linked national survey and vital statistics data

(2018) Edward W Gregg et al.   LANCET

Mechanisms of metformin action: In and out of the gut

(2018) Takahiro Minamii et al.   Journal of Diabetes Investigation

Down-regulation of vascular GLP-1 receptor expression in human subjects with obesity

(2018) Tomohiko Kimura et al.   Scientific Reports

The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases

(2018) Vicky W.W. Tsai et al.   Cell Metabolism

Effects of Liraglutide on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus With or Without History of Myocardial Infarction or Stroke

(2018) Subodh Verma et al.   CIRCULATION

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

GDF15 and energy balance: homing in on a mechanism

(2017) Irene Cimino et al.   NATURE MEDICINE

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

(2017) Hao Wu et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

(2017) Paul J Emmerson et al.   NATURE MEDICINE

Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice

(2017) Masahiro Konishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sustained expression of GLP-1 receptor differentially modulates β-cell functions in diabetic and nondiabetic mice

(2016) Fumiyo Kubo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic β-cells in obese type 2 diabetic db/db mice

(2016) Seizo Okauchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Growth Differentiation Factor 15 as a Novel Biomarker for Metformin

(2016) Hertzel C. Gerstein et al.   DIABETES CARE

Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE)

(2016) Tomoya Mita et al.   DIABETES CARE

Tofogliflozin Improves Insulin Resistance in Skeletal Muscle and Accelerates Lipolysis in Adipose Tissue in Male Mice

(2016) Atsushi Obata et al.   ENDOCRINOLOGY

Metformin for cancer prevention: a reason for optimism

(2016) Andrew T Chan   LANCET ONCOLOGY

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

(2016) Steven P. Marso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

(2016) Steven P. Marso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Short-term selective alleviation of glucotoxicity and lipotoxicity ameliorates the suppressed expression of key β-cell factors under diabetic conditions

(2015) Naoki Shimo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alogliptin, a Dipeptidyl Peptidase 4 Inhibitor, Prevents the Progression of Carotid Atherosclerosis in Patients With Type 2 Diabetes: The Study of Preventive Effects of Alogliptin on Diabetic Atherosclerosis (SPEAD-A)

(2015) Tomoya Mita et al.   DIABETES CARE

Role of Pancreatic Transcription Factors in Maintenance of Mature β-Cell Function

(2015) Hideaki Kaneto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preserving Mafa Expression in Diabetic Islet β-Cells Improves Glycemic Controlin Vivo

(2015) Taka-aki Matsuoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective effects of pioglitazone and/or liraglutide on pancreatic β-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes

(2015) Tomohiko Kimura et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Combination of DPP-4 inhibitor and PPARγ agonist exerts protective effects on pancreatic β-cells in diabetic db/db mice through the augmentation of IRS-2 expression

(2015) Hidenori Hirukawa et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Minireview: Autophagy in Pancreatic β-Cells and Its Implication in Diabetes

(2015) Hirotaka Watada et al.   MOLECULAR ENDOCRINOLOGY

Appropriate therapy for type 2 diabetes mellitus in view of pancreatic β-cell glucose toxicity: “the earlier, the better”

(2015) Hideaki Kaneto et al.   Journal of Diabetes

Insulin Receptor Substrate-2 (Irs2) in Endothelial Cells Plays a Crucial Role in Insulin Secretion

(2014) Shinji Hashimoto et al.   DIABETES

Pancreatic  -Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment

(2014) A. Bartolome et al.   DIABETES

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   DIABETES CARE

MafA is critical for maintenance of the mature beta cell phenotype in mice

(2014) Wataru Nishimura et al.   DIABETOLOGIA

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass

(2014) Ryan K. Mitchell et al.   HUMAN MOLECULAR GENETICS

Paradoxical insights into whole body metabolic adaptations following SGLT2 inhibition

(2014) William T. Cefalu   JOURNAL OF CLINICAL INVESTIGATION

Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production

(2014) Aurora Merovci et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients

(2014) Ele Ferrannini et al.   JOURNAL OF CLINICAL INVESTIGATION

The global implications of diabetes and cancer

(2014) Yuankai Shi et al.   LANCET

Type 2 diabetes and risk of pancreatic adenocarcinoma

(2014) Ahmadur Rahman   LANCET ONCOLOGY

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass

(2013) Iseki Takamoto et al.   DIABETOLOGIA

A Novel Function of Onecut1 Protein as a Negative Regulator ofMafAGene Expression

(2013) Kaoru Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Latest insights into the risk of cancer in diabetes

(2013) Hiroshi Noto et al.   Journal of Diabetes Investigation

Diabetes treatments and cancer risk: the importance of considering aspects of drug exposure

(2013) Jeremy J Walker et al.   Lancet Diabetes & Endocrinology

Vildagliptin preserves the mass and function of pancreatic β cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

(2012) S. Hamamoto et al.   DIABETES OBESITY & METABOLISM

Cancer Risk in Diabetic Patients Treated with Metformin: A Systematic Review and Meta-analysis

(2012) Hiroshi Noto et al.   PLoS One

Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces intimal thickening after vascular injury

(2011) Hiromasa Goto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle

(2011) Tetsuya Kubota et al.   Cell Metabolism

The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

(2011) M. Shimoda et al.   DIABETOLOGIA

Metformin and cancer: new applications for an old drug

(2011) Taxiarchis V. Kourelis et al.   MEDICAL ONCOLOGY

Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice

(2010) Satoshi Kawashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of MafA Expression in Pancreatic  -Cells in db/db Mice With Diabetes

(2010) T.-a. Matsuoka et al.   DIABETES

Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4

(2010) M. Arakawa et al.   DIABETES

A role for autophagy in β-cell life and death

(2010) Matilde Masini et al.   Islets

β-cell autophagy: A novel mechanism regulating β-cell function and mass- Lessons from β-cell-specific Atg7-deficient mice

(2010) Yoshio Fujitani et al.   Islets

Autophagy in human type 2 diabetes pancreatic beta cells

(2009) M. Masini et al.   DIABETOLOGIA

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

(2009) Luan Shu et al.   HUMAN MOLECULAR GENETICS

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation

(2008) Zhengyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE