Inflammatory Depression—Mechanisms and Non-Pharmacological Interventions

Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression

(2020) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

High-dose omega-3 polyunsaturated fatty acid supplementation might be more superior than low-dose for major depressive disorder in early therapy period: a network meta-analysis

(2020) Xu-dong Luo et al.   BMC Psychiatry

Significance of gastrointestinal tract in the therapeutic mechanisms of exercise in depression: Synchronism between brain and intestine through GBA

(2020) Yanna Liu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The Potential Effects of Probiotics and ω-3 Fatty Acids on Chronic Low-Grade Inflammation

(2020) Ashley N. Hutchinson et al.   Nutrients

Evaluation of the arachidonic acid pathway in bipolar disorder: a systematic review

(2020) Daniela V. Bavaresco et al.   MOLECULAR BIOLOGY REPORTS

Evaluation of an Immunomodulatory Probiotic Intervention for Veterans With Co-occurring Mild Traumatic Brain Injury and Posttraumatic Stress Disorder: A Pilot Study

(2020) Lisa A. Brenner et al.   Frontiers in Neurology

The neuroactive potential of the human gut microbiota in quality of life and depression

(2019) Mireia Valles-Colomer et al.   Nature Microbiology

Efficacy of anti‐inflammatory treatment on major depressive disorder or depressive symptoms: meta‐analysis of clinical trials

(2019) O. Köhler‐Forsberg et al.   ACTA PSYCHIATRICA SCANDINAVICA

Can’t or Won’t? Immunometabolic Constraints on Dopaminergic Drive

(2019) Michael T. Treadway et al.   TRENDS IN COGNITIVE SCIENCES

Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice

(2019) Sami Alzarea et al.   BEHAVIOURAL BRAIN RESEARCH

Physical Exercise and Neuroinflammation in Major Depressive Disorder

(2019) Zuleide M. Ignácio et al.   MOLECULAR NEUROBIOLOGY

Smoking and the intestinal microbiome

(2018) Ziv Savin et al.   ARCHIVES OF MICROBIOLOGY

Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: A randomized controlled trial

(2018) Faith Dickerson et al.   BIPOLAR DISORDERS

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

(2018) Morgane Sonia Thion et al.   CELL

Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial

(2018) Asma Kazemi et al.   CLINICAL NUTRITION

Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells

(2018) Meng Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The gut microbiota metabolite indole alleviates liver inflammation in mice

(2018) Martin Beaumont et al.   FASEB JOURNAL

Personalized Antidepressant Selection and Pathway to Novel Treatments: Clinical Utility of Targeting Inflammation

(2018) Manish Jha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recognizing Depression from the Microbiota–Gut–Brain Axis

(2018) Shan Liang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A meta-analysis of the use of probiotics to alleviate depressive symptoms

(2018) Qin Xiang Ng et al.   JOURNAL OF AFFECTIVE DISORDERS

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Kynurenine pathway in depression: A systematic review and meta-analysis

(2018) Kamiyu Ogyu et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Role of the gut microbiota in nutrition and health

(2018) Ana M Valdes et al.   BMJ-British Medical Journal

Role of the gut microbiota in nutrition and health

(2018) Ana M Valdes et al.   BMJ-British Medical Journal

Depression severity is associated with increased inflammation in veterans with peripheral artery disease

(2018) Natalie VM Hernandez et al.   VASCULAR MEDICINE

Immune and Neuroprotective Effects of Physical Activity on the Brain in Depression

(2018) Cristy Phillips et al.   Frontiers in Neuroscience

Aerobic exercise for adult patients with major depressive disorder in mental health services: A systematic review and meta-analysis

(2018) Ioannis D. Morres et al.   DEPRESSION AND ANXIETY

Neuroimmunomodulation in Major Depressive Disorder: Focus on Caspase 1, Inducible Nitric Oxide Synthase, and Interferon-Gamma

(2018) Antonio Inserra et al.   MOLECULAR NEUROBIOLOGY

Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study

(2018) Leszek Rudzki et al.   PSYCHONEUROENDOCRINOLOGY

Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome

(2017) Maria Ines Pinto-Sanchez et al.   GASTROENTEROLOGY

Oxidative Stress: Harms and Benefits for Human Health

(2017) Gabriele Pizzino et al.   Oxidative Medicine and Cellular Longevity

Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application

(2017) Erik Messamore et al.   PROGRESS IN LIPID RESEARCH

Interleukin-6 and depressive symptom severity in response to physical exercise

(2017) Catharina Lavebratt et al.   PSYCHIATRY RESEARCH

Can C-reactive protein inform antidepressant medication selection in depressed outpatients? Findings from the CO-MED trial

(2017) Manish K. Jha et al.   PSYCHONEUROENDOCRINOLOGY

Oxidative stress, inflammation and treatment response in major depression

(2017) Daniel Lindqvist et al.   PSYCHONEUROENDOCRINOLOGY

Exercise for patients with major depression: a systematic review with meta-analysis and trial sequential analysis

(2017) Jesper Krogh et al.   BMJ Open

Oxidative stress and cellular pathologies in Parkinson’s disease

(2017) Lesly Puspita et al.   Molecular Brain

Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression

(2016) Brian Hallahan et al.   BRITISH JOURNAL OF PSYCHIATRY

Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder

(2016) Emiko Aizawa et al.   JOURNAL OF AFFECTIVE DISORDERS

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

(2016) John R. Kelly et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Exercise as a treatment for depression: A meta-analysis adjusting for publication bias

(2016) Felipe B. Schuch et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Fish Oil Prevents Lipopolysaccharide-Induced Depressive-Like Behavior by Inhibiting Neuroinflammation

(2016) Zhe Shi et al.   MOLECULAR NEUROBIOLOGY

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

(2016) G B Rogers et al.   MOLECULAR PSYCHIATRY

Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression

(2016) E Haroon et al.   MOLECULAR PSYCHIATRY

Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation

(2016) Andrew H Miller et al.   NEUROPSYCHOPHARMACOLOGY

Inflammation Effects on Motivation and Motor Activity: Role of Dopamine

(2016) Jennifer C Felger et al.   NEUROPSYCHOPHARMACOLOGY

Inflammation, Glutamate and Glia: A Trio of Trouble in Mood Disorders

(2016) Ebrahim Haroon et al.   NEUROPSYCHOPHARMACOLOGY

Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial

(2016) Ghodarz Akkasheh et al.   NUTRITION

Structural & functional consequences of chronic psychosocial stress on the microbiome & host

(2016) Aadil Bharwani et al.   PSYCHONEUROENDOCRINOLOGY

Inflammation and Specific Symptoms of Depression

(2016) Markus Jokela et al.   JAMA Psychiatry

Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder

(2016) R J T Mocking et al.   Translational Psychiatry

Inflammation: Depression Fans the Flames and Feasts on the Heat

(2015) Janice K. Kiecolt-Glaser et al.   AMERICAN JOURNAL OF PSYCHIATRY

Altered fecal microbiota composition in patients with major depressive disorder

(2015) Haiyin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder

(2015) Jonathan Savitz et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression

(2015) J C Felger et al.   MOLECULAR PSYCHIATRY

Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study

(2015) M H Rapaport et al.   MOLECULAR PSYCHIATRY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?

(2015) Mohammad Jodeiri Farshbaf et al.   NEUROMOLECULAR MEDICINE

Roles of Indole as an Interspecies and Interkingdom Signaling Molecule

(2015) Jin-Hyung Lee et al.   TRENDS IN MICROBIOLOGY

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

(2015) John R. Kelly et al.   Frontiers in Cellular Neuroscience

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice

(2014) Carli J. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

An Inflammatory Biomarker as a Differential Predictor of Outcome of Depression Treatment With Escitalopram and Nortriptyline

(2014) Rudolf Uher et al.   AMERICAN JOURNAL OF PSYCHIATRY

Omega-3 Fatty Acids in the Prevention of Interferon-Alpha-Induced Depression: Results from a Randomized, Controlled Trial

(2014) Kuan-Pin Su et al.   BIOLOGICAL PSYCHIATRY

Exercise and associated dietary extremes impact on gut microbial diversity

(2014) Siobhan F Clarke et al.   GUT

Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?

(2014) Jacqueline Quak et al.   PSYCHONEUROENDOCRINOLOGY

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects

(2014) Ole Köhler et al.   JAMA Psychiatry

Impact of oxidative/nitrosative stress and inflammation on cognitive functions in patients with recurrent depressive disorders

(2014) Piotr Gałecki   MEDICAL SCIENCE MONITOR

Clinical Consequences of Diet-Induced Dysbiosis

(2013) Yee Kwan Chan et al.   ANNALS OF NUTRITION AND METABOLISM

Cerebrospinal fluid inflammatory markers in Parkinson’s disease – Associations with depression, fatigue, and cognitive impairment

(2013) Daniel Lindqvist et al.   BRAIN BEHAVIOR AND IMMUNITY

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders

(2013) Trevor W Stone et al.   BRITISH JOURNAL OF PHARMACOLOGY

Connecting inflammation with glutamate agonism in suicidality

(2013) Sophie Erhardt et al.   NEUROPSYCHOPHARMACOLOGY

Chronic Interferon-α Decreases Dopamine 2 Receptor Binding and Striatal Dopamine Release in Association with Anhedonia-Like Behavior in Nonhuman Primates

(2013) Jennifer C Felger et al.   NEUROPSYCHOPHARMACOLOGY

Alterations of the gut microbiota in high-fat diet mice is strongly linked to oxidative stress

(2012) Yi Qiao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Dopaminergic Mechanisms of Reduced Basal Ganglia Responses to Hedonic Reward During Interferon Alfa Administration

(2012) Lucile Capuron et al.   ARCHIVES OF GENERAL PSYCHIATRY

Dysregulated relationship of inflammation and oxidative stress in major depression

(2012) B.J. Rawdin et al.   BRAIN BEHAVIOR AND IMMUNITY

Tyrosine metabolism during interferon-alpha administration: Association with fatigue and CSF dopamine concentrations

(2012) Jennifer C. Felger et al.   BRAIN BEHAVIOR AND IMMUNITY

Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

(2012) Philip C. Calder   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut

(2012) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

Pro-inflammatory cytokines as predictors of antidepressant effects of exercise in major depressive disorder

(2012) C D Rethorst et al.   MOLECULAR PSYCHIATRY

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling

(2012) Carissa M. Thomas et al.   PLoS One

Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C

(2011) A K Smith et al.   MOLECULAR PSYCHIATRY

Immune system to brain signaling: Neuropsychopharmacological implications

(2011) Lucile Capuron et al.   PHARMACOLOGY & THERAPEUTICS

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is Depression an Inflammatory Disorder?

(2011) Charles L. Raison et al.   Current Psychiatry Reports

Effect of Lactobacilli on Paracellular Permeability in the Gut

(2011) Siv Ahrne et al.   Nutrients

Peripheral and cerebral metabolic abnormalities of the tryptophan–kynurenine pathway in a murine model of major depression

(2010) Anthony Laugeray et al.   BEHAVIOURAL BRAIN RESEARCH

A Meta-Analytic Review of Polyunsaturated Fatty Acid Compositions in Patients with Depression

(2010) Pao-Yen Lin et al.   BIOLOGICAL PSYCHIATRY

Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation

(2010) Michael T. Bailey et al.   BRAIN BEHAVIOR AND IMMUNITY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids

(2010) Rebecca Wall et al.   NUTRITION REVIEWS

Interleukin-6 Is Elevated in the Cerebrospinal Fluid of Suicide Attempters and Related to Symptom Severity

(2009) Daniel Lindqvist et al.   BIOLOGICAL PSYCHIATRY

Phospholipase A2 and Cyclooxygenase 2 Genes Influence the Risk of Interferon-α–Induced Depression by Regulating Polyunsaturated Fatty Acids Levels

(2009) Kuan-Pin Su et al.   BIOLOGICAL PSYCHIATRY

Crosstalk in Inflammation: The Interplay of Glucocorticoid Receptor-Based Mechanisms and Kinases and Phosphatases

(2009) Ilse M. E. Beck et al.   ENDOCRINE REVIEWS

The diseasome of physical inactivity - and the role of myokines in muscle-fat cross talk

(2009) Bente K. Pedersen   JOURNAL OF PHYSIOLOGY-LONDON

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

(2009) T. Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

The Antidepressive Effects of Exercise

(2009) Chad D. Rethorst et al.   SPORTS MEDICINE

Mode of action of mood stabilizers: is the arachidonic acid cascade a common target?

(2008) J S Rao et al.   MOLECULAR PSYCHIATRY

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY