Article
Medicine, Research & Experimental
Mennatallah A. Gowayed, Norhan S. El-Sayed, Noura A. Matar, Elham A. Afify, Samar O. El-Ganainy
Summary: This study revealed the positive effects of PNU-120596 on motor dysfunction and neuroinflammation associated with Parkinson's disease. PNU acted through the JAK2/NF-kappa B/GSk3 beta/TNF-alpha neuroinflammatory pathways, offering a potential therapeutic strategy for Parkinson's disease.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Sami Alzarea, Muzaffar Abbas, Patrick J. Ronan, Kabirullah Lutfy, Shafiqur Rahman
Summary: Nicotinic acetylcholine receptors, especially the alpha 7 subtype, play a critical role in neuroinflammation and microglial activation associated with major depressive disorder. The positive allosteric modulator PNU120596, which targets the alpha 7 subtype, can reduce the expression of HAAO and the formation of QUIN, thereby alleviating the symptoms related to microglia activation and neuroinflammation in MDD.
Article
Immunology
Tehila Mizrachi, Oshrit Marsha, Karen Brusin, Yael Ben-David, Ganesh A. Thakur, Adi Vaknin-Dembinsky, Millet Treinin, Talma Brenner
Summary: GAT107, an ago-PAM of alpha 7 nAChR, can significantly reduce disease severity and neuroinflammation in EAE by activating the receptor, leading to decreased pro-inflammatory cytokine production and increased anti-inflammatory cytokine IL-10. It also alters the expression of immune cell markers and directly activates alpha 7 nAChR in immune cells of MS patients and healthy donors.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Elisa Navarro, Diana M. Norden, Paige J. Trojanowski, Jonathan P. Godbout, Manuela G. Lopez
Summary: The stimulation of alpha 7 nAChR signaling reduces microglial activation in an in vivo LPS-based model, but this cholinergic-dependent regulation appears to be dysfunctional in microglia of aged mice.
Article
Cell Biology
Joshua D. Frenster, Hediye Erdjument-Bromage, Gabriele Stephan, Niklas Ravn-Boess, Shuai Wang, Wenke Liu, Devin Bready, Jordan Wilcox, Bjorn Kieslich, Manuel Jankovic, Caroline Wilde, Susanne Horn, Norbert Strater, Ines Liebscher, Torsten Schoneberg, David Fenyo, Thomas A. Neubert, Dimitris G. Placantonakis
Summary: This study identifies PTK7 as an extracellular binding partner of GPR133 in glioblastoma, and shows that PTK7 enhances GPR133 signaling by binding to the N-terminal fragment of GPR133. This interaction is potentially relevant to the pathogenesis of glioblastoma.
Article
Neurosciences
Muzaffar Abbas, Sami Alzarea, Roger L. Papke, Shafiqur Rahman
Summary: This study found that in a mouse model of inflammatory pain, TQS exerts analgesic effects by downregulating BDNF and p-NKCC1 in the hippocampus and upregulating KCC2.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2021)
Review
Biochemistry & Molecular Biology
Lydia J. Bye, Rocio K. Finol-Urdaneta, Han-Shen Tae, David J. Adams
Summary: Nicotinic acetylcholine receptors (nAChRs) expressed in microglia play a crucial role in regulating immune functions through the cholinergic anti-inflammatory pathway. Dysregulation of this pathway can lead to neuroinflammation associated with neurodegenerative diseases. Disease-associated microglia exhibit an altered phenotype characterized by enhanced defense functions and impaired nurturing and repairing functions. Cholinergic modulation of neuroinflammation holds promise as a potential treatment avenue.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Food Science & Technology
Zhipeng Li, Qingchen Wang, Zhonghong Zhang, Xiao Zhang, Xintong Wu, Li Li, Yi Zhang, Yihua Yu
Summary: Luteolin inhibits neuroinflammation and alleviates depression-like behavior by upregulating A20 and Nrf2.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Medicinal
Francis S. Willard, David B. Wainscott, Aaron D. Showalter, Cynthia Stutsman, Wenzhen Ma, Guemalli R. Cardona, Richard W. Zink, Christopher M. Corkins, Qi Chen, Nathan Yumibe, Javier Agejas, Graham R. Cumming, Jose Miguel Minguez, Alma Jimenez, Ana Mateo, Ana M. Castano, Daniel A. Briere, Kyle W. Sloop, Ana B. Bueno
Summary: LSN3318839 is a positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R), enhancing the activity of weak metabolite GLP-1(9-36)NH2 and full-length ligand GLP-1(7-36)NH2 through G protein-coupled signaling. Experiments show that the combination of LSN3318839 and GLP-1(9-36)NH2 produces insulin secretion and glucose lowering effects similar to GLP-1(7-36)NH2.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Neurosciences
Zhixin Peng, Xiaoheng Li, Jun Li, Yuan Dong, Yuhao Gao, Yajin Liao, Meichen Yan, Zengqiang Yuan, Jinbo Cheng
Summary: This study unveiled the role of Dlg1 in microglia, showing that knocking down Dlg1 can reduce microglial activation and alleviate LPS-induced depression-like behavior. This discovery provides a new potential therapeutic target for the clinical treatment of depression.
NEUROSCIENCE BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Qimeng Li, Akos Nemecz, Gabriel Ayme, Gabrielle Dejean de la Batie, Marie S. Prevost, Stephanie Pons, Nathalie Barilone, Rayen Baachaoui, Uwe Maskos, Pierre Lafaye, Pierre-Jean Corringer
Summary: Two single-domain antibody fragments, C4 and E3, have been found to bind to the α7-nAChR and have different functional properties, indicating the importance of the extracellular site.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ji-Yun Kang, Dong-Cheol Baek, Chang-Gue Son, Jin-Seok Lee
Summary: Microglia are important targets for treating neuropsychiatric disorders. Pinus spp. succinum extract (PSE) has strong antineuroinflammatory and antidepressant properties, potentially involving the regulation of NF-κB translocation and the CX3CR1/Nrf2 pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Tianyuan Wang, Huandi Weng, Hongji Zhou, Zecheng Yang, Zhongyou Tian, Biao Xi, Yalan Li
Summary: This study aimed to investigate the protective effects and mechanisms of action of esketamine in postoperative depression (POD). The results showed that esketamine can significantly improve depression-like symptoms caused by anesthesia and surgery, and restore synaptogenesis in the medial prefrontal cortex (mPFC) that had been perturbed by inflammation. The anti-inflammatory effects of esketamine may be mediated by the BDNF/TrkB signaling pathway.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Kaleeckal G. Harikumar, Thomas Coudrat, Aditya J. Desai, Maoqing Dong, Daniela G. Dengler, Sebastian G. B. Furness, Arthur Christopoulos, Denise Wootten, Eduard A. Sergienko, Patrick M. Sexton, Laurence J. Miller
Summary: This study proposes a new strategy for improving obesity treatment by enhancing the action of the CCK receptor, reducing the likelihood of side effects and toxicity. By identifying positive allosteric modulators (PAMs) with minimal intrinsic agonist activity and studying their mechanisms of action, it is possible to correct abnormal signaling in high-cholesterol environments and develop more effective drugs. The research focuses on compound 1, a weak partial agonist with PAM activity, which enhances CCK signaling without inducing receptor internalization, providing a potential avenue for developing targeted therapies for metabolic regulation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, Research & Experimental
Ruisi Liu, Yueling Gong, Chenyi Xia, Yemin Cao, Cheng Zhao, Mingmei Zhou
Summary: Neuroinflammation plays a crucial role in the pathogenesis of depression, and itaconate, a metabolite secreted by macrophages, has potent anti-inflammatory and immunomodulatory effects that can improve depressive symptoms through various mechanisms. With the development of optimization and new delivery systems, itaconate has gained significantly improved application value and therapeutic potential. This article provides an overview of the immunomodulatory effects of itaconate and its promising application as a precursor of antidepressants in inflammatory depression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Nazrul Islam, Emma Cichero, Shafiqur Rahman, Isuru Ranasinghe
Summary: Atrial fibrillation (AF) is a common cardiac arrhythmia, with approximately 335 million patients worldwide. Current pharmacological treatment has limitations, such as slow onset and high doses with potential adverse effects. This review discusses the advantages of novel pulmonary delivery for AF management.
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
(2023)
Review
Biochemistry & Molecular Biology
Asif Ahmad Bhat, Gaurav Gupta, Obaid Afzal, Imran Kazmi, Fahad A. Al-Abbasi, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I. Alzarea, Sachin Kumar Singh, Kamal Dua
Summary: Risperidone, as an atypical antipsychotic, has been used off-label for treating behavioural and psychological symptoms of dementia, and has shown potential pharmacological interactions in various neurological diseases. However, more research is needed to determine its actual effectiveness and role in different diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Biochemistry & Molecular Biology
Manish Purohit, Gaurav Gupta, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sami I. Alzarea, Imran Kazmi, Waleed Hassan Almalki, Monica Gulati, Indu Pal Kaur, Sachin Kumar Singh, Kamal Dua
Summary: The JAK/STAT system is a crucial signaling pathway for the signal transduction of several key cytokines in sepsis. Activation of JAK kinases by cytokine-receptor binding leads to selective phosphorylation of STATs, which play a key role in gene transcription in the nucleus. The JAK/STAT pathway is involved in various biological activities, including hematopoiesis, immunological modulation, cell differentiation, and apoptosis. This review discusses the importance of the JAK/STAT signaling pathway in severe lung inflammation, which is a major public health concern worldwide.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Medicine, General & Internal
Abdullah Salah Alanazi, Shahid Shah, Ghulam Abbas, Musaddique Hussain, Ammara Saleem, Haris Khurram, Usman Rashid Chand, Tauqeer Hussain Mallhi, Yusra Habib Khan, Kainat Ilyas, Savaira Tariq, Abdullah Jamil, Abdulaziz Ibrahim Alzarea, Sami Ibrahim Alzarea
Summary: This study aimed to assess the quality of services provided at community pharmacies in Punjab, Pakistan by determining the level of patient satisfaction and related factors. A questionnaire-based survey was conducted from May 2021 to July 2021 using stratified random sampling method. Results showed that community pharmacy services to patients were not satisfactory, with concerns raised regarding the absence of pharmacists in the pharmacy and the lack of provision for counseling time.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Article
Engineering, Chemical
Sami I. I. Alzarea, Sumera Qasim, Muhammad Afzal, Omar Awad Alsaidan, Hassan H. H. Alhassan, Metab Alharbi, Mohammed Alqinyah, Fahaad S. S. Alenazi
Summary: In this study, an anandamide reuptake inhibitor, VDM11, was selected as a potential candidate for managing post-COVID depression. The results revealed that VDM11 can attenuate neuroinflammation and directly target multiple genes associated with depressive symptoms. Molecular docking analysis showed that VDM11 interacts well with these target genes. The efficacy of VDM11 in alleviating depression was further demonstrated in an LPS-induced depression model. However, further pharmacological studies are required to validate these findings.
Article
Neurosciences
Laica Tolentino, Asif Iqbal, Shafiqur Rahman, Kabirullah Lutfy
Summary: This study investigated the role of endogenous beta-endorphin in food deprivation-induced increases in food intake and binge eating. The results suggest that food deprivation significantly increases food intake, but beta-endorphin may not be involved in this process. Prior exposure to a high-fat diet promotes binge-eating behavior, and this effect is modestly decreased in beta-endorphin knockout mice. Overall, beta-endorphin may play a modest role in mediating palatability-driven feeding, but not hunger-associated feeding.
Review
Pharmacology & Pharmacy
Imran Kazmi, Mohammad Arshad Javed Shaikh, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I. Alzarea, Fahad A. Al-Abbasi, Manisha Pandey, Harish Dureja, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Summary: Lung cancer is a leading cause of cancer-related mortality and remains difficult to cure, especially in metastatic cases. Nanoparticles, particularly chitosan-coated ones, have unique characteristics that enable more effective and cost-efficient treatment by adjusting release rates and precise drug transport. Microencapsulation and micro-nano mixing systems have been developed for efficient aerosolization and inhalation of nanocarriers. This review highlights the advances and challenges in using chitosan-coated nano-medicines for lung cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Neurosciences
Ghallab Alotaibi, Amna Khan, Patrick J. Ronan, Kabirullah Lutfy, Shafiqur Rahman
Summary: This study investigated the effects of the GLT-1 activator LDN-212320 on microglial activation in a mouse model of inflammatory pain. Results showed that LDN-212320 reduced CFA-induced tactile allodynia and thermal hyperalgesia by upregulating astroglial GLT-1 and CX43 expression and decreasing microglial activation.
Review
Chemistry, Multidisciplinary
Riya Thapa, Haider Ali, Obaid Afzal, Asif Ahmad Bhat, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Abdulmalik Saleh Alfawaz Altamimi, Neha Jain, Manisha Pandey, Neeraj Kumar Fuloria, Mahendran Sekar, Dhanalekshmi Unnikrishnan Meenakshi, Vikash Jakhmola, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Summary: Breast cancer, the most common cancer among women, is typically managed with surgery, radiation therapy, and chemotherapy. However, chemotherapy drugs often lack specificity, resulting in adverse effects. Mesoporous silica nanoparticles (MSNPs) have emerged as a potential solution to enhance drug delivery in cancer treatment by offering advantageous properties such as high porosity, large surface area, versatile pore sizes, and compatibility with biological systems. MSNPs can effectively load chemotherapeutic agents and improve drug uptake and release, resulting in enhanced anticancer activity. Additionally, MSNP-based drug delivery improves pharmacodynamic and pharmacokinetic characteristics, ultimately improving therapeutic outcomes for breast cancer treatment.
JOURNAL OF NANOPARTICLE RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Nikita Kaushal, Manish Kumar, Abhishek Tiwari, Varsha Tiwari, Kamini Sharma, Ajay Sharma, Arya Lakshmi Marisetti, Madan Mohan Gupta, Imran Kazmi, Sami Alzarea, Waleed Hassan Almalki, Gaurav Gupta
Summary: This study developed a prednisolone acetate polymeric micelles (PM) system for ocular inflammation related to allergic uveitis. The optimized in situ gel showed superior ex vivo transcorneal permeation with zero-order kinetics, making it a promising candidate for treating anterior uveitis.
Review
Pathology
Md Sadique Hussain, Obaid Afzal, Gaurav Gupta, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Neelima Kukreti, Saurabh Gupta, Kunjbihari Sulakhiya, Sachin Kumar Singh, Kamal Dua
Summary: Atherosclerosis, a chronic inflammatory disease, can be influenced by dysregulated lncRNAs that affect the NF-kB signaling pathway, potentially serving as therapeutic targets.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Nasir Hayat Malik, Muhammad Nouman Tahir, Tariq G. Alsahli, Md. Mahedi Hassan Tusher, Sami I. Alzarea, Bader Alsuwayt, Shah Jahan, Hesham A. M. Gomaa, Mohamed E. Shaker, Muhammad Ali, Irfan Anjum, Muhammad Tariq Khan, Muhammad Roman, Ramla Shabbir
Summary: Geraniol has shown potential as an antiarthritic agent in a rat model of inflammatory arthritis. It effectively reduced paw edema, inflammation, and protected joint structure. The mechanism of action may involve downregulation of pro-inflammatory mediators and proteases.
Article
Biochemistry & Molecular Biology
Saif Ullah, Taseer Ahmad, Muhammad Ikram, Hafiz Majid Rasheed, Muhammad Ijaz Khan, Taous Khan, Tariq G. Alsahli, Sami I. Alzarea, Musaad Althobaiti, Abdul Jabbar Shah
Summary: Myocardial infarction (MI) is a leading cause of premature death, and protecting the myocardium from ischemia is a key area of research. This study found that 7-hydroxy frullanolide (7-HF) showed potential cardioprotective effects by reducing myocardial injury, preserving tissue histology, and decreasing the release of cardiac biomarkers. Additionally, 7-HF modulated the expression of cardioprotective genes Nrf2 and iNOS, and improved cardiac function.
Article
Health Care Sciences & Services
Abdulaziz Ibrahim Alzarea, Yusra Habib Khan, Abdullah Salah Alanazi, Nasser Hadal Alotaibi, Sami I. Alzarea, Ziyad Saeed Almalki, Saad S. Alqahtani, Tauqeer Hussain Mallhi
Summary: This study aimed to assess the involvement of community pharmacists in public health services in remote areas of Saudi Arabia, as well as the barriers they face and strategies to improve their role. The results showed that a majority of community pharmacists were involved in public health activities and were willing to provide these services. Education and awareness were found to be the most effective strategies to increase pharmacist involvement.
Article
Toxicology
Suman Rohilla, Mahaveer Singh, Sami I. Alzarea, Waleed Hassan Almalki, Fahad A. Al-Abbasi, Imran Kazmi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta
Summary: Conventional therapies for lung cancer, such as radiation, surgery, and chemotherapy, often lead to undesirable side effects. The major challenge in developing new drug therapies for lung cancer is resistance, which involves mutations and disruptions in signaling pathways. This review article highlights the progress in developing molecularly targeted therapies for non-small cell lung cancer (NSCLC) by studying biomarkers such as EGFR, ALK, MET, ROS-1, KRAS, and B-RAF. However, resistance development limits the clinical benefits of these new drugs.
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)