Involvement of Cholinergic, Adrenergic, and Glutamatergic Network Modulation with Cognitive Dysfunction in Alzheimer’s Disease

Brain activity of benzoate, a D-amino acid oxidase inhibitor, in patients with mild cognitive impairment in a randomized, double-blind, placebo controlled clinical trial

(2021) Hsien-Yuan Lane et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Sodium benzoate for the treatment of behavioral and psychological symptoms of dementia (BPSD): A randomized, double-blind, placebo-controlled, 6-week trial

(2019) C-H Lin et al.   JOURNAL OF PSYCHOPHARMACOLOGY

D-glutamate, D-serine, and D-alanine differ in their roles in cognitive decline in patients with Alzheimer's disease or mild cognitive impairment

(2019) Chieh-Hsin Lin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

N-methyl D-aspartate receptor subtype 2B antagonist, Ro 25-6981, attenuates neuropathic pain by inhibiting postsynaptic density 95 expression

(2018) Ling-Er Huang et al.   Scientific Reports

Postsynaptic localization and regulation of AMPA receptors and Cav1.2 by β2 adrenergic receptor/PKA and Ca2+/CaMKII signaling

(2018) Tommaso Patriarchi et al.   EMBO JOURNAL

Assessment of the Target Engagement and d-Serine Biomarker Profiles of the d-Amino Acid Oxidase Inhibitors Sodium Benzoate and PGM030756

(2017) Eimear Howley et al.   NEUROCHEMICAL RESEARCH

Blood levels of D-amino acid oxidase vs. D-amino acids in reflecting cognitive aging

(2017) Chieh-Hsin Lin et al.   Scientific Reports

Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease

(2017) Sarah C. Kelly et al.   Acta Neuropathologica Communications

Reduced basal forebrain atrophy progression in a randomized Donepezil trial in prodromal Alzheimer’s disease

(2017) Enrica Cavedo et al.   Scientific Reports

Reduced Regional Cortical Thickness Rate of Change in Donepezil-Treated Subjects With Suspected Prodromal Alzheimer’s Disease

(2016) Enrica Cavedo et al.   JOURNAL OF CLINICAL PSYCHIATRY

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

(2016) Ting Yang et al.   JOURNAL OF NEUROSCIENCE

Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer′s disease mice

(2016) Peng Zhao et al.   Neural Regeneration Research

CSF d-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls

(2016) Elisanne A.L.M. Biemans et al.   NEUROBIOLOGY OF AGING

The effect of D-serine administration on cognition and mood in older adults

(2016) Marcos Avellar et al.   Oncotarget

Supplementation with D-serine prevents the onset of cognitive deficits in adult offspring after maternal immune activation

(2016) Yuko Fujita et al.   Scientific Reports

Reversal of aging-related emotional memory deficits by norepinephrine via regulating the stability of surface AMPA receptors

(2015) Yi Luo et al.   AGING CELL

Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease

(2015) Bruno Dubois et al.   Alzheimers & Dementia

D-Cycloserine in Neuropsychiatric Diseases: A Systematic Review

(2015) Sebastian Schade et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

d-Serine in the aging hippocampus

(2015) Jean-Marie Billard   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Efficacy of a glycine transporter 1 inhibitor TASP0315003 in animal models of cognitive dysfunction and negative symptoms of schizophrenia

(2015) Shigeyuki Chaki et al.   PSYCHOPHARMACOLOGY

Distribution of vesicular glutamate transporters in the human brain

(2015) Érika Vigneault et al.   Frontiers in Neuroanatomy

Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex

(2015) Bo Tang et al.   Scientific Reports

Glutamate Receptor Modulation Is Restricted to Synaptic Microdomains

(2015) Gyorgy Lur et al.   Cell Reports

d-serine levels in Alzheimer’s disease: implications for novel biomarker development

(2015) C Madeira et al.   Translational Psychiatry

The serine shuttle between glia and neurons: implications for neurotransmission and neurodegeneration: Figure 1

(2015) Herman Wolosker et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer’s Disease

(2015) Khushbu K. Modi et al.   PLoS One

White Matter Injuries Induced by MK-801 in a Mouse Model of Schizophrenia Based on NMDA Antagonism

(2014) Yun Xiu et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Ear2 Deletion Causes Early Memory and Learning Deficits in APP/PS1 Mice

(2014) M. P. Kummer et al.   JOURNAL OF NEUROSCIENCE

Inhibition of the Polyamine System Counteracts β-Amyloid Peptide-Induced Memory Impairment in Mice: Involvement of Extrasynaptic NMDA Receptors

(2014) Guilherme Monteiro Gomes et al.   PLoS One

β1-adrenergic receptor activation enhances memory in Alzheimer's disease model

(2014) Laurence Coutellier et al.   Annals of Clinical and Translational Neurology

Benzoate, a D-Amino Acid Oxidase Inhibitor, for the Treatment of Early-Phase Alzheimer Disease: A Randomized, Double-Blind, Placebo-Controlled Trial

(2013) Chieh-Hsin Lin et al.   BIOLOGICAL PSYCHIATRY

Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells

(2013) Nagendra S. Singh et al.   CELLULAR SIGNALLING

Activation of α7-containing nicotinic receptors on astrocytes triggers AMPA receptor recruitment to glutamatergic synapses

(2013) Xulong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: Implications for neuropsychiatric diseases

(2013) Hong Lin et al.   NEUROBIOLOGY OF DISEASE

Nicotinic  7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss

(2013) C Tackenberg et al.   Cell Death & Disease

NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors

(2013) X Zhou et al.   Cell Death & Disease

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

(2012) Thomas Papouin et al.   CELL

Presynaptic inhibition of glutamate transmission by α2 receptors in the VTA

(2012) Carlos A. Jiménez-Rivera et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease

(2012) Katsuya Harada et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Multicenter, Add-On Randomized Controlled Trial of Low-Dosed-Serine for Negative and Cognitive Symptoms of Schizophrenia

(2012) Mark Weiser et al.   JOURNAL OF CLINICAL PSYCHIATRY

β2-Adrenergic receptor supports prolonged theta tetanus-induced LTP

(2012) Hai Qian et al.   JOURNAL OF NEUROPHYSIOLOGY

NR2B-Containing NMDA Receptors Expression and Their Relationship to Apoptosis in Hippocampus of Alzheimer’s Disease-Like Rats

(2012) Zhi’an Liu et al.   NEUROCHEMICAL RESEARCH

Activation of alpha1-adrenoceptors enhances glutamate release onto ventral tegmental area dopamine cells

(2012) M.C. Velásquez-Martinez et al.   NEUROSCIENCE

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Recent Advances in the Discovery of D-Amino Acid Oxidase Inhibitors and Their Therapeutic Utility in Schizophrenia

(2011) Dana V. Ferraris et al.   CURRENT PHARMACEUTICAL DESIGN

Cooperation between cholinergic and glutamatergic receptors are essential to induce BDNF-dependent long-lasting memory storage

(2011) Sheeja Navakkode et al.   HIPPOCAMPUS

Amyloid β Peptide-(1–42) Induces Internalization and Degradation of β2Adrenergic Receptors in Prefrontal Cortical Neurons

(2011) Dayong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo

(2011) N. Takata et al.   JOURNAL OF NEUROSCIENCE

Activation of β-adrenergic receptors facilitates heterosynaptic translation-dependent long-term potentiation

(2011) Steven A. Connor et al.   JOURNAL OF PHYSIOLOGY-LONDON

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

Previously unsuspected widespread cellular and tissue distribution of β-adrenoceptors and its relevance to drug action

(2011) C.J. Daly et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of α7 nicotinic receptors and internalization of NMDA receptors

(2010) H Shen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

(2010) Elena Alberdi et al.   CELL CALCIUM

Binding of amyloid β peptide to β2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

(2010) Dayong Wang et al.   FASEB JOURNAL

Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

(2010) P. Xia et al.   JOURNAL OF NEUROSCIENCE

'Silent' priming of translation-dependent LTP by  -adrenergic receptors involves phosphorylation and recruitment of AMPA receptors

(2010) G. Tenorio et al.   LEARNING & MEMORY

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Good night and good luck: Norepinephrine in sleep pharmacology

(2009) Heather A. Mitchell et al.   BIOCHEMICAL PHARMACOLOGY

Assembly of a β2-adrenergic receptor—GluR1 signalling complex for localized cAMP signalling

(2009) Mei-ling A Joiner et al.   EMBO JOURNAL

Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1H)-one Series of Potentd-Amino Acid Oxidase (DAAO) Inhibitors†

(2009) Allen J. Duplantier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deletion of the  7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease

(2009) G. Dziewczapolski et al.   JOURNAL OF NEUROSCIENCE

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

The locus coeruleus and noradrenergic modulation of cognition

(2009) Susan J. Sara   NATURE REVIEWS NEUROSCIENCE

The involvement of the NMDA receptor d-serine/glycine site in the pathophysiology and treatment of schizophrenia

(2009) Viviane Labrie et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Progression from mild cognitive impairment to Alzheimerʼs disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment

(2009) Steven Ferris et al.   Pharmacogenetics and Genomics

Cholinergic direct inhibition ofN-methyl-D aspartate receptor-mediated currents in the rat neocortex

(2009) Jorge Flores-Hernandez et al.   SYNAPSE

Presynaptic and postsynaptic modulation of glutamatergic synaptic transmission by activation of α1- and β-adrenoceptors in layer V pyramidal neurons of rat cerebral cortex

(2009) Masayuki Kobayashi et al.   SYNAPSE

NEUROPROTECTIVE EFFECTS OF A SELECTIVEN-METHYL-d-ASPARTATE NR2B RECEPTOR ANTAGONIST IN THE 6-HYDROXYDOPAMINE RAT MODEL OF PARKINSON'S DISEASE

(2008) KR Leaver et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties

(2007) Tiziana Adage et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease

(2007) Guojun Chen et al.   NEUROBIOLOGY OF AGING

Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease

(2007) Alireza Kashani et al.   NEUROBIOLOGY OF AGING

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING