N-methyl D-aspartate receptor subtype 2B antagonist, Ro 25-6981, attenuates neuropathic pain by inhibiting postsynaptic density 95 expression

Perturbing NR2B–PSD-95 interaction relieves neuropathic pain by inactivating CaMKII-CREB signaling

(2017) Fangxia Xu et al.   NEUROREPORT

Rolipram, a Selective Phosphodiesterase 4 Inhibitor, Ameliorates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain through Inhibition of Inflammatory Cytokines in the Dorsal Root Ganglion

(2017) Hee Kee Kim et al.   Frontiers in Pharmacology

SIRPα1-SHP2 Interaction Regulates Complete Freund Adjuvant–Induced Inflammatory Pain via Src-Dependent GluN2B Phosphorylation in Rats

(2016) Cheng-Yuan Lai et al.   ANESTHESIA AND ANALGESIA

Pain regulation by non-neuronal cells and inflammation

(2016) R.-R. Ji et al.   SCIENCE

Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons

(2016) Eva Ramos-Fernández et al.   Oncotarget

Lentiviral vector-encoded microRNA-based shRNA-mediated gene knockdown ofN-methyl-D-aspartate receptors in skin reduces pain

(2016) Chien-Cheng Liu et al.   Brain and Behavior

Neuropathic Allodynia Involves Spinal Neurexin-1β-dependent Neuroligin-1/Postsynaptic Density-95/NR2B Cascade in Rats

(2015) Tzer-Bin Lin et al.   ANESTHESIOLOGY

Delayed Activation of Spinal Microglia Contributes to the Maintenance of Bone Cancer Pain in Female Wistar Rats via P2X7 Receptor and IL-18

(2015) Y. Yang et al.   JOURNAL OF NEUROSCIENCE

Inflammatory Pain May Induce Cognitive Impairment Through an Interlukin-6-Dependent and Postsynaptic Density-95-Associated Mechanism

(2014) Longqiu Yang et al.   ANESTHESIA AND ANALGESIA

Intrathecal Injection of the Peptide Myr-NR2B9c Attenuates Bone Cancer Pain Via Perturbing N-Methyl-D-Aspartate Receptor-PSD-95 Protein Interactions in Mice

(2014) Yue Liu et al.   ANESTHESIA AND ANALGESIA

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord contributes to chronic visceral pain in rats

(2013) Xiao-qing Luo et al.   BRAIN RESEARCH

Calmodulin Kinase IV-dependent CREB activation is required for neuroprotection via NMDA receptor-PSD95 disruption

(2013) Karen F. S. Bell et al.   JOURNAL OF NEUROCHEMISTRY

Spinal Serum-Inducible and Glucocorticoid-Inducible Kinase 1 Mediates Neuropathic Pain via Kalirin and Downstream PSD-95-Dependent NR2B Phosphorylation in Rats

(2013) H.-Y. Peng et al.   JOURNAL OF NEUROSCIENCE

Combination pharmacotherapy for management of chronic pain: from bench to bedside

(2013) Ian Gilron et al.   LANCET NEUROLOGY

Spinal synaptic scaffolding protein Homer 1b/c regulates CREB phosphorylation and c-fos activation induced by inflammatory pain in rats

(2013) Yong-Xing Yao et al.   NEUROSCIENCE LETTERS

Involvement of spinal microglia and interleukin-18 in the anti-nociceptive effect of dexmedetomidine in rats subjected to CCI

(2013) Shuang-Shuang Li et al.   NEUROSCIENCE LETTERS

Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-d-aspartate receptor

(2013) Ming Jiang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms

(2012) Christian A. von Hehn et al.   NEURON

Spinal SIRPα1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats

(2012) Hsien-Yu Peng et al.   PAIN

Knockdown of Synaptic Scaffolding Protein Homer 1b/c Attenuates Secondary Hyperalgesia Induced by Complete Freundʼs Adjuvant in Rats

(2011) Yong-Xing Yao et al.   ANESTHESIA AND ANALGESIA

Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury

(2011) Chun-Yi Leel et al.   EUROPEAN JOURNAL OF PAIN

Neuronal Plasticity in the Cingulate Cortex of Rats Following Esophageal Acid Exposure in Early Life

(2011) Banani Banerjee et al.   GASTROENTEROLOGY

Perturbing PSD-95 Interactions With NR2B-subtype Receptors Attenuates Spinal Nociceptive Plasticity and Neuropathic Pain

(2011) Richard D'Mello et al.   MOLECULAR THERAPY

Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472

(2010) Shinji Matsumura et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Up-Regulation of Anterior Cingulate Cortex NR2B Receptors Contributes to Visceral Pain Responses in Rats

(2009) Jing Fan et al.   GASTROENTEROLOGY

Activation of extracellular signal-regulated protein kinases 5 in the spinal cord contributes to the neuropathic pain behaviors induced by CCI in rats

(2009) Lin Zhang et al.   NEUROLOGICAL RESEARCH

Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain

(2008) Xiao-Xiu Qu et al.   EXPERIMENTAL NEUROLOGY

Expression of AMPA Receptor Subunits at Synapses in Laminae I–III of the Rodent Spinal Dorsal Horn

(2008) Erika Polgár et al.   Molecular Pain