Assessment of the Target Engagement and d-Serine Biomarker Profiles of the d-Amino Acid Oxidase Inhibitors Sodium Benzoate and PGM030756

In Vitro Effects of Sodium Benzoate on Th1/Th2 Deviation in Patients with Multiple Sclerosis

(2016) N. Rezaei et al.   IMMUNOLOGICAL INVESTIGATIONS

Sodium Benzoate, a Food Additive and a Metabolite of Cinnamon, Enriches Regulatory T Cells via STAT6-Mediated Upregulation of TGF-β

(2016) Madhuchhanda Kundu et al.   JOURNAL OF IMMUNOLOGY

Modulating NMDA Receptor Function with d-Amino Acid Oxidase Inhibitors: Understanding Functional Activity in PCP-Treated Mouse Model

(2016) Henry Sershen et al.   NEUROCHEMICAL RESEARCH

Effects of sodium benzoate on pre-pulse inhibition deficits and hyperlocomotion in mice after administration of phencyclidine

(2015) Akiko Matsuura et al.   ACTA NEUROPSYCHIATRICA

Allosteric modulators of NMDA receptors: multiple sites and mechanisms

(2015) Shujia Zhu et al.   CURRENT OPINION IN PHARMACOLOGY

Discontinued neuropathic pain therapy between 2009–2015

(2015) Nebojsa Nick Knezevic et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Upregulates Ciliary Neurotrophic Factor in Astrocytes and Oligodendrocytes

(2015) Khushbu K. Modi et al.   NEUROCHEMICAL RESEARCH

D-Amino-Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not in Monkey or Dog

(2015) Camilo Rojas et al.   NEUROPSYCHOPHARMACOLOGY

Effects of sodium benzoate on pre-pulse inhibition deficits and hyperlocomotion in mice after administration of phencyclidine

(2015) Akiko Matsuura et al.   ACTA NEUROPSYCHIATRICA

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Evaluation of human D-amino acid oxidase inhibition by anti-psychotic drugs in vitro

(2014) Miho Shishikura et al.   BioScience Trends

The Antiviral Drug Acyclovir Is a Slow-Binding Inhibitor of d-Amino Acid Oxidase

(2013) Masumi Katane et al.   BIOCHEMISTRY

Benzoate, a D-Amino Acid Oxidase Inhibitor, for the Treatment of Early-Phase Alzheimer Disease: A Randomized, Double-Blind, Placebo-Controlled Trial

(2013) Chieh-Hsin Lin et al.   BIOLOGICAL PSYCHIATRY

D-Amino Acid Oxidase Inhibitors as a Novel Class of Drugs for Schizophrenia Therapy

(2013) Silvia Sacchi et al.   CURRENT PHARMACEUTICAL DESIGN

4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors

(2013) Takeshi Hondo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

(2013) Robert J. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Add-on Treatment of Benzoate for Schizophrenia

(2013) Hsien-Yuan Lane et al.   JAMA Psychiatry

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

(2012) Thomas Papouin et al.   CELL

NMDA Receptor and Schizophrenia: A Brief History

(2012) J. T. Coyle   SCHIZOPHRENIA BULLETIN

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

(2011) Paul Morgan et al.   DRUG DISCOVERY TODAY

Modulation of NMDA receptor function by inhibition of d-amino acid oxidase in rodent brain

(2011) Christine A. Strick et al.   NEUROPHARMACOLOGY

The neurobiology of D-amino acid oxidase and its involvement in schizophrenia

(2009) L Verrall et al.   MOLECULAR PSYCHIATRY

The discovery of fused pyrrole carboxylic acids as novel, potent d-amino acid oxidase (DAO) inhibitors

(2008) Tim Sparey et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophrenia

(2008) Sanae Iwana et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY