Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence

The autoimmune susceptibility gene, PTPN2, restricts expansion of a novel mouse adherent-invasive E. coli

(2020) Ali Shawki et al.   Gut Microbes

New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD

(2019) Anaïs Larabi et al.   Autophagy

Replication of Crohn’s Disease Mucosal E. coli Isolates inside Macrophages Correlates with Resistance to Superoxide and Is Dependent on Macrophage NF-kappa B Activation

(2019) Ahmed Tawfik et al.   Pathogens

The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients

(2018) Bahtiyar Yilmaz et al.   PLoS One

PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer

(2018) Marianne R. Spalinger et al.   Cell Reports

Adherent-invasiveEscherichia coliin inflammatory bowel disease

(2017) Carolina Palmela et al.   GUT

Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis

(2017) Paola Conigliaro et al.   PLoS One

Macrophage defense mechanisms against intracellular bacteria

(2015) Günter Weiss et al.   IMMUNOLOGICAL REVIEWS

Crohnʼs Disease–associated Escherichia coli Survive in Macrophages by Suppressing NFκB Signaling

(2014) Khalidur Rahman et al.   INFLAMMATORY BOWEL DISEASES

Subversion of human intestinal mucosa innate immunity by a Crohn’s disease-associated E. coli

(2014) A Jarry et al.   Mucosal Immunology

PTPN2 controls differentiation of CD4+ T cells and limits intestinal inflammation and intestinal dysbiosis

(2014) M R Spalinger et al.   Mucosal Immunology

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Complex host genetics influence the microbiome in inflammatory bowel disease

(2014) Dan Knights et al.   Genome Medicine

Autophagosome maturation and lysosomal fusion

(2013) Ian G. Ganley   Essays in Biochemistry

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer

(2013) Aurélie Couturier-Maillard et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of Protein Tyrosine Phosphatase Non-Receptor Type 2 by Spermidine Exerts Anti-Inflammatory Effects in Human THP-1 Monocytes and in a Mouse Model of Acute Colitis

(2013) Belén Morón et al.   PLoS One

Evidence from Genetics for a Role of Autophagy and Innate Immunity in IBD Pathogenesis

(2012) Miles Parkes   DIGESTIVE DISEASES

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Subversion of Autophagy in Adherent Invasive Escherichia coli-Infected Neutrophils Induces Inflammation and Cell Death

(2012) Abderrahman Chargui et al.   PLoS One

Bacteria as Trigger for Chronic Gastrointestinal Disorders

(2011) Philippe Marteau et al.   DIGESTIVE DISEASES

Protein Tyrosine Phosphatase Nonreceptor Type 2 Regulates Autophagosome Formation in Human Intestinal Cells

(2011) Michael Scharl et al.   INFLAMMATORY BOWEL DISEASES

Crohnʼs disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy

(2011) Michael Scharl et al.   INFLAMMATORY BOWEL DISEASES

Loss of protein tyrosine phosphatase N2 potentiates epidermal growth factor suppression of intestinal epithelial chloride secretion

(2010) Michael Scharl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Distinct and overlapping genetic loci in crohnʼs disease and ulcerative colitis: Correlations with pathogenesis

(2010) Matti Waterman et al.   INFLAMMATORY BOWEL DISEASES

Intestinal macrophages and response to microbial encroachment

(2010) P D Smith et al.   Mucosal Immunology

Novel Genetic Risk Markers for Ulcerative Colitis in the IL2/IL21 Region Are in Epistasis With IL23R and Suggest a Common Genetic Background for Ulcerative Colitis and Celiac Disease

(2009) Jürgen Glas et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Origin of the Lamina Propria Dendritic Cell Network

(2009) Milena Bogunovic et al.   IMMUNITY

Cation-independent Mannose 6-Phosphate Receptor

(2009) Richard N. Bohnsack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

(2009) E. Slack et al.   SCIENCE