PTPN2 controls differentiation of CD4+ T cells and limits intestinal inflammation and intestinal dysbiosis

PTPN2 attenuates T-cell lymphopenia-induced proliferation

(2014) Florian Wiede et al.   Nature Communications

A decrease of the butyrate-producing speciesRoseburia hominisandFaecalibacterium prausnitziidefines dysbiosis in patients with ulcerative colitis

(2013) Kathleen Machiels et al.   GUT

Increased Proportions of Bifidobacterium and the Lactobacillus Group and Loss of Butyrate-Producing Bacteria in Inflammatory Bowel Disease

(2013) W. Wang et al.   JOURNAL OF CLINICAL MICROBIOLOGY

IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic

(2013) L. A. Zenewicz et al.   JOURNAL OF IMMUNOLOGY

Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses

(2013) Keiji Hirota et al.   NATURE IMMUNOLOGY

Activation of Protein Tyrosine Phosphatase Non-Receptor Type 2 by Spermidine Exerts Anti-Inflammatory Effects in Human THP-1 Monocytes and in a Mouse Model of Acute Colitis

(2013) Belén Morón et al.   PLoS One

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells

(2012) Mary A. Zimmerman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Microbial butyrate and its role for barrier function in the gastrointestinal tract

(2012) Svenja Plöger et al.   Annals of the New York Academy of Sciences

Th17 cells in type 1 diabetes

(2012) Shiying Shao et al.   CELLULAR IMMUNOLOGY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

The SILVA ribosomal RNA gene database project: improved data processing and web-based tools

(2012) Christian Quast et al.   NUCLEIC ACIDS RESEARCH

TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?

(2012) Ashish K. Marwaha et al.   Frontiers in Immunology

TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation

(2011) Trine Olsen et al.   CYTOKINE

Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes

(2011) Alessandra Ferraro et al.   DIABETES

Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives

(2011) M. Joossens et al.   GUT

Crohnʼs disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy

(2011) Michael Scharl et al.   INFLAMMATORY BOWEL DISEASES

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

(2011) Florian Wiede et al.   JOURNAL OF CLINICAL INVESTIGATION

TCR-dependent transformation of mature memory phenotype T cells in mice

(2011) Xi Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

(2011) Eleonora A. M. Festen et al.   PLoS Genetics

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Protein tyrosine phosphatase N2 regulates TNF -induced signalling and cytokine secretion in human intestinal epithelial cells

(2010) M. Scharl et al.   GUT

Protein Tyrosine Phosphatase non-Receptor Type 2 regulates IFN-γ-induced cytokine signaling in THP-1 monocytes

(2010) Michael Scharl et al.   INFLAMMATORY BOWEL DISEASES

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Protection of Epithelial Barrier Function by the Crohn's Disease Associated Gene Protein Tyrosine Phosphatase N2

(2009) Michael Scharl et al.   GASTROENTEROLOGY

T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease

(2009) Karen M. Doody et al.   IMMUNOLOGICAL REVIEWS

Autoimmunity: increasing suspects in the CD4+ T cell lineup

(2009) Matthew T Palmer et al.   NATURE IMMUNOLOGY

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS