Management of hospitalised adults with coronavirus disease-19 (COVID-19): A European Respiratory Society living guideline

Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial

(2021) Viviane C Veiga et al.   BMJ-British Medical Journal

Presumed Asymptomatic Carrier Transmission of COVID-19

(2020) Yan Bai et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: A single center study of 100 patients in Brescia, Italy

(2020) Paola Toniati et al.   AUTOIMMUNITY REVIEWS

Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China

(2020) Yan Deng et al.   CHINESE MEDICAL JOURNAL

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

(2020) Xueting Yao et al.   CLINICAL INFECTIOUS DISEASES

High-flow nasal cannula for COVID-19 patients: low risk of bio-aerosol dispersion

(2020) Jie Li et al.   EUROPEAN RESPIRATORY JOURNAL

Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study

(2020) Rong-Hui Du et al.   EUROPEAN RESPIRATORY JOURNAL

Factors associated with prolonged viral shedding and impact of Lopinavir/Ritonavir treatment in hospitalised non-critically ill patients with SARS-CoV-2 infection

(2020) Dan Yan et al.   EUROPEAN RESPIRATORY JOURNAL

Continuous positive airway pressure to avoid intubation in SARS-CoV-2 pneumonia: a two-period retrospective case-control study

(2020) Mathilde Oranger et al.   EUROPEAN RESPIRATORY JOURNAL

Clinical characteristics and outcomes of hospitalised patients with COVID-19 treated in Hubei (epicenter) and outside Hubei (non-epicenter): A Nationwide Analysis of China

(2020) Wen-hua Liang et al.   EUROPEAN RESPIRATORY JOURNAL

COVID-19: minimising risk to healthcare workers during aerosol-producing respiratory therapy using an innovative constant flow canopy

(2020) Yochai Adir et al.   EUROPEAN RESPIRATORY JOURNAL

Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers

(2020) Jordi Rello et al.   EUROPEAN RESPIRATORY JOURNAL

More awareness is needed for severe acute respiratory syndrome coronavirus 2019 transmission through exhaled air during non-invasive respiratory support: experience from China

(2020) Lili Guan et al.   EUROPEAN RESPIRATORY JOURNAL

Awake Prone Positioning for Non-intubated Oxygen Dependent COVID-19 Pneumonia Patients

(2020) Ziqin Ng et al.   EUROPEAN RESPIRATORY JOURNAL

Pathogenesis of COVID-19 from a cell biology perspective

(2020) Robert J. Mason   EUROPEAN RESPIRATORY JOURNAL

Pulmonary embolism in patients with Covid-19 pneumonia

(2020) Florian Bompard et al.   EUROPEAN RESPIRATORY JOURNAL

The perils of premature phenotyping in COVID: a call for caution

(2020) Lieuwe D. J. Bos et al.   EUROPEAN RESPIRATORY JOURNAL

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

COVID-19 illness in native and immunosuppressed states: A clinical–therapeutic staging proposal

(2020) Hasan K. Siddiqi et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA

(2020) Isaac Ghinai et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19

(2020) Jason D. Goldman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protect our healthcare workers

(2020) Fiona Godlee   BMJ-British Medical Journal

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

(2020) Annemarie B Docherty et al.   BMJ-British Medical Journal

Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases

(2020) Kollengode Ramanathan et al.   Lancet Respiratory Medicine

Protecting healthcare workers from SARS-CoV-2 infection: practical indications

(2020) Martina Ferioli et al.   European Respiratory Review

Helmet continuous positive airway pressure and prone positioning: A proposal for an early management of COVID-19 patients

(2020) F. Longhini et al.   Pulmonology

Characterization of the Inflammatory Response to Severe COVID-19 Illness

(2020) Oliver J McElvaney et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

COVID-19 Clinical Trials: Unravelling a Methodological Gordian Knot

(2020) Alexander G. Mathioudakis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19

(2020) Caleb P. Skipper et al.   ANNALS OF INTERNAL MEDICINE

Association between treatment with colchicine and improved survival in a single-centre cohort of adult hospitalised patients with COVID-19 pneumonia and acute respiratory distress syndrome

(2020) Mirko Scarsi et al.   ANNALS OF THE RHEUMATIC DISEASES

Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study

(2020) Sofia Ramiro et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of interferon β-1a in treatment of severe COVID-19: A randomized clinical trial

(2020) Effat Davoudi-Monfared et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prone and Lateral Positioning in Spontaneously Breathing Patients With COVID-19 Pneumonia Undergoing Noninvasive Helmet CPAP Treatment

(2020) Mariangela Retucci et al.   CHEST

The rationale for the use of colchicine in COVID-19: comments on the letter by Cumhur Cure M et al.

(2020) Silvia Piantoni et al.   CLINICAL RHEUMATOLOGY

Prone positioning in patients treated with non-invasive ventilation for COVID-19 pneumonia in an Italian emergency department

(2020) Davide Bastoni et al.   EMERGENCY MEDICINE JOURNAL

Potential of regulatory T cell-based therapies in the management of severe COVID-19

(2020) Emmanuel Stephen-Victor et al.   EUROPEAN RESPIRATORY JOURNAL

Building the house of CARDS by phenotyping on the fly

(2020) Rajkumar Rajendram   EUROPEAN RESPIRATORY JOURNAL

Rationale and significance of patient selection in awake prone positioning for COVID-19 pneumonia

(2020) Ching Feng Huang et al.   EUROPEAN RESPIRATORY JOURNAL

Development of a Clinical Decision Support System for Severity Risk Prediction and Triage of COVID-19 Patients at Hospital Admission: an International Multicenter Study

(2020) Guangyao Wu et al.   EUROPEAN RESPIRATORY JOURNAL

Comparison of severity scores for COVID-19 patients with pneumonia: a retrospective study

(2020) Guohui Fan et al.   EUROPEAN RESPIRATORY JOURNAL

Helmet CPAP treatment in patients with COVID-19 pneumonia: a multicenter, cohort study

(2020) Stefano Aliberti et al.   EUROPEAN RESPIRATORY JOURNAL

Feasibility and clinical impact of out-of-ICU non-invasive respiratory support in patients with COVID-19 related pneumonia

(2020) Cosimo Franco et al.   EUROPEAN RESPIRATORY JOURNAL

Pathogenesis of COVID-19-induced ARDS: implications for an aging population

(2020) Manuel A. Torres Acosta et al.   EUROPEAN RESPIRATORY JOURNAL

Response to “COVID-19 conundrum: Clinical phenotyping based on pathophysiology as a promising approach to guide therapy in a novel illness” and “Strengthening the foundation of the house of CARDS by phenotyping on the fly” and “COVID-19 phenotypes: leading or misleading?”

(2020) Lieuwe D.J. Bos et al.   EUROPEAN RESPIRATORY JOURNAL

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

(2020) Aaron J. Wilk et al.   NATURE MEDICINE

Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19

(2020) Alexandre B. Cavalcanti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients: A structured summary of a study protocol for a randomised controlled trial

(2020) Tom Wilkinson et al.   Trials

Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities

(2020) Puja Mehta et al.   Lancet Respiratory Medicine

Feasibility and physiological effects of prone positioning in non-intubated patients with acute respiratory failure due to COVID-19 (PRON-COVID): a prospective cohort study

(2020) Anna Coppo et al.   Lancet Respiratory Medicine

Severe immunosuppression and not a cytokine storm characterize COVID-19 infections

(2020) Kenneth E. Remy et al.   JCI Insight

Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019

(2020) Spyridon G. Deftereos et al.   JAMA Network Open

Hydroxychloroquine in the Treatment of COVID-19: A Multicenter Randomized Controlled Study

(2020) Sherief Abd-Elsalam et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Compassionate drug (mis)use during pandemics: lessons for COVID-19 from 2009

(2020) Amanda M. Rojek et al.   BMC Medicine

Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial

(2020) Oriol Mitjà et al.   CLINICAL INFECTIOUS DISEASES

High-flow nasal cannula for COVID-19 patients: risk of bio-aerosol dispersion

(2020) Jie Li et al.   EUROPEAN RESPIRATORY JOURNAL

High-flow nasal oxygen: a safe, efficient treatment for COVID-19 patients not in an ICU

(2020) Tiphaine Guy et al.   EUROPEAN RESPIRATORY JOURNAL

Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID-19 patients: results from a randomised controlled clinical trial

(2020) Maryam Edalatifard et al.   EUROPEAN RESPIRATORY JOURNAL

Inflammation and Intussusceptive Angiogenesis in COVID-19: everything in and out of Flow

(2020) Maximilian Ackermann et al.   EUROPEAN RESPIRATORY JOURNAL

High-flow nasal cannula for COVID-19 patients: risk of bio-aerosol dispersion

(2020) Judith Elshof et al.   EUROPEAN RESPIRATORY JOURNAL

Continuous positive airway pressure in Covid-19 patients with moderate-to-severe respiratory failure

(2020) Claudia Brusasco et al.   EUROPEAN RESPIRATORY JOURNAL

Elevated D-dimers and lack of anticoagulation predict PE in severe COVID-19 patients

(2020) Basile Mouhat et al.   EUROPEAN RESPIRATORY JOURNAL

Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome

(2020) Luke Y.C. Chen et al.   EUROPEAN RESPIRATORY JOURNAL

Safety and effectiveness of azithromycin in patients with COVID-19: An open-label randomised trial

(2020) Ehsan Sekhavati et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19

(2020) Pierre-François Dequin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19

(2020) Bruno M. Tomazini et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Emergency Use Authorizations During the COVID-19 Pandemic

(2020) Kyle Thomson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19

(2020) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19

(2020) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

(2020) Flavio Protasio Veras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

(2020) Peter W Horby et al.   LANCET

Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial

(2020) Remo H M Furtado et al.   LANCET

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

A dynamic COVID-19 immune signature includes associations with poor prognosis

(2020) Adam G. Laing et al.   NATURE MEDICINE

Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

(2020) John H. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Continuous Positive Airway Pressure (CPAP) face-mask ventilation is an easy and cheap option to manage a massive influx of patients presenting acute respiratory failure during the SARS-CoV-2 outbreak: A retrospective cohort study

(2020) Sophie Alviset et al.   PLoS One

Anticoagulation outcomes in hospitalized Covid‐19 patients: A systematic review and meta‐analysis of case‐control and cohort studies

(2020) Ahmed M. Kamel et al.   REVIEWS IN MEDICAL VIROLOGY

Awake pronation with helmet continuous positive airway pressure for COVID-19 acute respiratory distress syndrome patients outside the ICU: A case series

(2020) G. Paternoster et al.   Medicina Intensiva

Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score

(2020) Stephen R Knight et al.   BMJ-British Medical Journal

Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study

(2020) Olivia V Swann et al.   BMJ-British Medical Journal

Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)

(2020) Sophie Juul et al.   PLOS MEDICINE

Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia

(2020) Olivier Hermine et al.   JAMA Internal Medicine

Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia

(2020) Carlo Salvarani et al.   JAMA Internal Medicine

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

(2020) Daniel E Leisman et al.   Lancet Respiratory Medicine

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

(2020) Elizabeth R. Mann et al.   Science Immunology

Real‐world prevalence and consequences of potential drug‐drug interactions in the first‐wave COVID‐19 treatments

(2020) Noemí Martínez‐López‐de‐Castro et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

(2020) Ioanna-Evdokia Galani et al.   NATURE IMMUNOLOGY

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

(2020) Andre C. Kalil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

(2020) Carlos Salama et al.   NEW ENGLAND JOURNAL OF MEDICINE

A multicenter, randomized, open-label, controlled trial to evaluate the efficacy and tolerability of hydroxychloroquine and a retrospective study in adult patients with mild to moderate coronavirus disease 2019 (COVID-19)

(2020) Cheng-Pin Chen et al.   PLoS One

Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019

(2020) David Jiménez et al.   CHEST

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

(2020) Phillip D Monk et al.   Lancet Respiratory Medicine

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

(2019) Jean-Claude Tardif et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis

(2019) James D Chalmers et al.   Lancet Respiratory Medicine

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

(2018) Maria L. Agostini et al.   mBio

Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial

(2017) Peter G Gibson et al.   LANCET

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure

(2015) Jean-Pierre Frat et al.   NEW ENGLAND JOURNAL OF MEDICINE

Colchicine—Update on mechanisms of action and therapeutic uses

(2015) Ying Ying Leung et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations

(2013) Jeff Andrews et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Risks of population antimicrobial resistance associated with chronic macrolide use for inflammatory airway diseases

(2013) David J Serisier   Lancet Respiratory Medicine

Grading quality of evidence and strength of recommendations in clinical practice guidelines Part 3 of 3. The GRADE approach to developing recommendations

(2011) J. L. Brożek et al.   ALLERGY

GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias)

(2011) Gordon H. Guyatt et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

GRADE guidelines: 2. Framing the question and deciding on important outcomes

(2010) Gordon H. Guyatt et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY