Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes

(2020) James T. England et al.   BLOOD REVIEWS

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation

(2020) Daniel E. Leisman et al.   INTENSIVE CARE MEDICINE

Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19

(2020) Tobias Herold et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis

(2020) Franco Locatelli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amelioration of COVID‐19‐related cytokine storm syndrome: parallels to chimeric antigen receptor‐T cell cytokine release syndrome

(2020) Ryan L. Hoiland et al.   BRITISH JOURNAL OF HAEMATOLOGY

Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized COVID-19 Patients

(2020) Christina C. Price et al.   CHEST

Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)?

(2020) Alice Huertas et al.   EUROPEAN RESPIRATORY JOURNAL

IL-6–based mortality risk model for hospitalized patients with COVID-19

(2020) Rocio Laguna-Goya et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent

(2020) Alessio Mazzoni et al.   JOURNAL OF CLINICAL INVESTIGATION

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

COVID-19-associated coagulopathy: An exploration of mechanisms

(2020) Meaghan E Colling et al.   VASCULAR MEDICINE

Is a “Cytokine Storm” Relevant to COVID-19?

(2020) Pratik Sinha et al.   JAMA Internal Medicine

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

(2020) George Goshua et al.   Lancet Haematology

A dynamic COVID-19 immune signature includes associations with poor prognosis

(2020) Adam G. Laing et al.   NATURE MEDICINE

Recommendations for the management of hemophagocytic lymphohistiocytosis in adults

(2019) Paul La Rosée et al.   BLOOD

Extreme hyperferritinaemia, soluble interleukin-2 receptor, and haemophagocytic lymphohistiocytosis

(2018) Luke Y. C. Chen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hemophagocytic syndromes (HPSs) including hemophagocytic lymphohistiocytosis (HLH) in adults: A systematic scoping review

(2016) Anna Hayden et al.   BLOOD REVIEWS

Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial

(2014) Frits van Rhee et al.   LANCET ONCOLOGY

Sustained efficacy of the monoclonal anti-interleukin-1 beta antibody canakinumab in a 9-month trial in Schnitzler's syndrome

(2012) Heleen D de Koning et al.   ANNALS OF THE RHEUMATIC DISEASES

Hemophagocytosis causes a consumptive anemia of inflammation

(2011) Erin E. Zoller et al.   JOURNAL OF EXPERIMENTAL MEDICINE