Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel

hERGCentral: A Large Database to Store, Retrieve, and Analyze Compound-Human Ether-à-go-go Related Gene Channel Interactions to Facilitate Cardiotoxicity Assessment in Drug Development

(2011) Fang Du et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Quantitative prediction of the arrhythmogenic effects of de novo hERG mutations in computational models of human ventricular tissues

(2011) Alan P. Benson et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Ginsenoside Rg3 decelerates hERG K+ channel deactivation through Ser631 residue interaction

(2011) Sun-Hye Choi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo

(2010) Jürgen Biermann et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacological Activation of Kv11.1 in Transgenic Long QT-1 Rabbits

(2010) Bo Hjorth Bentzen et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome

(2010) Alessandra Moretti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Electrophysiologic characterization of a novel hERG channel activator

(2009) Zhi Su et al.   BIOCHEMICAL PHARMACOLOGY

Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: Evidence for clinically significant IKr-IKs α-subunit interaction

(2009) Peter Biliczki et al.   HEART RHYTHM

The genetic basis of long QT and short QT syndromes: A mutation update

(2009) Paula L. Hedley et al.   HUMAN MUTATION

Pharmacological Removal of Human Ether-a-go-go-Related Gene Potassium Channel Inactivation by 3-Nitro-N-(4-phenoxyphenyl) Benzamide (ICA-105574)

(2009) A. C. Gerlach et al.   MOLECULAR PHARMACOLOGY

Discovery of a Novel Activator of KCNQ1-KCNE1 K+ Channel Complexes

(2009) Karen Mruk et al.   PLoS One

Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)

(2008) X. Xu et al.   MOLECULAR PHARMACOLOGY