Evidence for the hERG Liability of Antihistamines, Antipsychotics, and Anti-Infective Agents: A Systematic Literature Review From the ARITMO Project

Evolution of strategies to improve preclinical cardiac safety testing

(2016) Gary Gintant et al.   NATURE REVIEWS DRUG DISCOVERY

An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

(2016) William J. Crumb et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Evaluation of drug-induced QT interval prolongation in animal and human studies: a literature review of concordance

(2015) Hugo M Vargas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sudden cardiac and sudden unexpected death related to antipsychotics: A meta-analysis of observational studies

(2015) F Salvo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Systematic Reviews of Animal Studies; Missing Link in Translational Research?

(2014) Judith van Luijk et al.   PLoS One

Blockage of hERG current and the disruption of trafficking as induced by roxithromycin

(2013) Sheng-Na Han et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration

(2013) Hee-Kyung Hong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The anesthetized guinea pig: An effective early cardiovascular derisking and lead optimization model

(2013) Pierre Morissette et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Human embryonic stem cell derived cardiac myocytes detect hERG-mediated repolarization effects, but not Nav1.5 induced depolarization delay

(2013) Yusheng Qu et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

A history of the role of the hERG channel in cardiac risk assessment

(2013) David Rampe et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

In VitroCardiovascular Effects of Dihydroartemisin-Piperaquine Combination Compared with Other Antimalarials

(2012) Franco Borsini et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of mixed ion channel effects in the cardiovascular safety assessment of the novel anti-MRSA fluoroquinolone JNJ-Q2

(2012) G Eichenbaum et al.   BRITISH JOURNAL OF PHARMACOLOGY

Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?

(2012) Hua Rong Lu et al.   BRITISH JOURNAL OF PHARMACOLOGY

hERG subunit composition determines differential drug sensitivity

(2011) N Abi-Gerges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Prolongation of Cardiac Ventricular Repolarization Under Paliperidone: How and How Much?

(2011) Patrick Vigneault et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

A step towards characterisation of electrophysiological profile of torsadogenic drugs

(2011) Pascal Champeroux et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Pharmacokinetic–pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys

(2011) Kenny J. Watson et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Blockade of hERG K+ channel by antimalarial drug, primaquine

(2010) Ki-Suk Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Identification of Human Ether-à-go-go Related Gene Modulators by Three Screening Platforms in an Academic Drug-Discovery Setting

(2010) Xi-Ping Huang et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

The Action of a Novel Fluoroquinolone Antibiotic Agent Antofloxacin Hydrochloride on Human-Ether-à-go-go-Related Gene Potassium Channel

(2010) Jia Guo et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Extracellular potassium dependency of block of HERG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation.

(2010) Brad Barrows et al.   Channels

Minimizing Repolarization-Related Proarrhythmic Risk in Drug Development and Clinical Practice

(2010) Attila S. Farkas et al.   DRUGS

Fluconazole inhibits hERG K+ channel by direct block and disruption of protein trafficking

(2010) Shengna Han et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Electrophysiologic, Pharmacokinetic, and Pharmacodynamic Values Indicating a Higher Risk of Torsades de Pointes

(2010) Yeong-Liang Lin et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Amisulpride Overdose Is Frequently Associated With QT Prolongation and Torsades de Pointes

(2010) Geoffrey K. Isbister et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Cyamemazine metabolites: effects on human cardiac ion channels in-vitro and on the QTc interval in guinea pigs

(2010) William Crumb et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Response of IKrand hERG Currents to the Antipsychotics Tiapride and Sulpiride

(2010) Su-Hyun Jo et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

(2010) Gary Gintant   PHARMACOLOGY & THERAPEUTICS

Interactions at Human ether-à-go-go–Related Gene Channels

(2010) Anne Friemel et al.   TOXICOLOGICAL SCIENCES

Inhibition of the HERG Channel by Droperidol Depends on Channel Gating and Involves the S6 Residue F656

(2009) Tao Luo et al.   ANESTHESIA AND ANALGESIA

hERG-related drug toxicity and models for predicting hERG liability and QT prolongation

(2009) Emanuel Raschi et al.   Expert Opinion on Drug Metabolism & Toxicology

Cellular Mechanism of the QT Prolongation Induced by Sulpiride

(2009) Hyang-Ae Lee et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

H1 antihistamine drug promethazine directly blocks hERG K+ channel

(2009) Su-Hyun Jo et al.   PHARMACOLOGICAL RESEARCH

A HESI consortium approach to assess the human predictive value of non-clinical repolarization assays

(2009) Elena S. Trepakova et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model

(2008) X Yao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-a-go-go-Related Gene Channels

(2008) M. J. Perrin et al.   MOLECULAR PHARMACOLOGY

Torsades de pointes liability inter-model comparisons: The experience of the QT PRODACT initiative

(2008) Keitaro Hashimoto   PHARMACOLOGY & THERAPEUTICS

What is “quality of evidence” and why is it important to clinicians?

(2008) Gordon H Guyatt et al.   BMJ-British Medical Journal

Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome

(2007) H Takemasa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine

(2006) So-Young Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block

(2006) M B Thomsen et al.   BRITISH JOURNAL OF PHARMACOLOGY