Advance of structural modification of nucleosides scaffold

Identification of a C3′-nitrile nucleoside analogue inhibitor of pancreatic cancer cell line growth

(2020) Marc-Olivier Labbé et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

(2020) Timothy P. Sheahan et al.   Nature Communications

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

(2019) Egor Tchesnokov et al.   Viruses-Basel

Synthesis and anti-CVB3 activity of 4-amino acid derivative substituted pyrimidine nucleoside analogues

(2019) Le Tao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antitumor activities investigation of a C-nucleoside analogue of ribavirin

(2019) Nazarii Sabat et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold

(2018) Katherine L. Seley-Radtke et al.   ANTIVIRAL RESEARCH

Design, synthesis, and biological evaluation of new 1,2,3-triazolo-2′-deoxy-2′-fluoro- 4′-azido nucleoside derivatives as potent anti-HBV agents

(2018) Yuan Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Self-assembling nanoparticles based on cytarabine prodrug for enhanced leukemia treatment

(2018) Ruiling Liu et al.   JOURNAL OF MOLECULAR LIQUIDS

The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies

(2018) B.G. Murphy et al.   VETERINARY MICROBIOLOGY

Synthesis of a 3′- C -ethynyl-β- d -ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides

(2018) Fabian Hulpia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates

(2018) Charles Dumontet et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A preclinical evaluation of cytarabine prodrug nanofibers assembled from cytarabine-lauric acid conjugate toward solid tumors

(2018) Ruiling Liu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Antiviral effects of selected nucleoside analogues against human parechoviruses A1 and A3

(2018) Kristina Lanko et al.   ANTIVIRAL RESEARCH

The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold

(2018) Mary K. Yates et al.   ANTIVIRAL RESEARCH

Design, synthesis and preliminary biological evaluation of new [1,2,3]triazolo[4,5- d ]pyrimidine/thiourea hybrids as antiproliferative agents

(2017) Zhong-Hua Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (LSD1/KDM1A) inhibitors

(2017) Shuai Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of thiazolo[5,4-d]pyrimidine derivatives as potent antiproliferative agents through the drug repurposing strategy

(2017) Zhong-Hua Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antiproliferative activity of thiazolo[5,4- d ]pyrimidine derivatives through the atom replacement strategy

(2017) Zhong-Hua Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The thiopurine nucleoside analogue 6-methylmercaptopurine riboside (6MMPr) effectively blocks Zika virus replication

(2017) Otavio Valério de Carvalho et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Nanoassemblies from amphiphilic cytarabine prodrug for leukemia targeted therapy

(2017) Jing Liu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Acyclonucleosides bearing coplanar arylethynyltriazole nucleobases: synthesis, structural analysis, and biological evaluation

(2017) Mimi Chen et al.   NEW JOURNAL OF CHEMISTRY

Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents

(2016) Cai Lin et al.   ANTIVIRAL RESEARCH

Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus

(2016) Luděk Eyer et al.   ANTIVIRAL RESEARCH

Structure–activity relationship study of anticancer thymidine–quinoxaline conjugates under the low radiance of long wavelength ultraviolet light for photodynamic therapy

(2016) Dejun Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of [1,2,3]triazolo[4,5- d ]pyrimidine derivatives possessing a hydrazone moiety as antiproliferative agents

(2016) Zhong-Hua Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Highly enhanced leukemia therapy and oral bioavailability from a novel amphiphilic prodrug of cytarabine

(2016) Jing Liu et al.   RSC Advances

BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

(2016) Raymond Taylor et al.   Journal of Infection and Public Health

A Novel Triazole Nucleoside Suppresses Prostate Cancer Cell Growth by Inhibiting Heat Shock Factor 1 and Androgen Receptor

(2015) Yi Xia et al.   Anti-Cancer Agents in Medicinal Chemistry

The search for nucleoside/nucleotide analog inhibitors of dengue virus

(2015) Yen-Liang Chen et al.   ANTIVIRAL RESEARCH

Characterization of the activity of 2′-C-methylcytidine against dengue virus replication

(2015) Jin-Ching Lee et al.   ANTIVIRAL RESEARCH

Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways

(2015) Qiong Wei et al.   BMC CANCER

Spiral assembly of amphiphilic cytarabine prodrug assisted by probe sonication: Enhanced therapy index for leukemia

(2015) Jing Liu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Design, Synthesis, and Structure–Activity Relationship of Novel LSD1 Inhibitors Based on Pyrimidine–Thiourea Hybrids As Potent, Orally Active Antitumor Agents

(2015) Li-Ying Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Safe integration of nelarabine into intensive chemotherapy in newly diagnosed T-cell acute lymphoblastic leukemia: Children's Oncology Group Study AALL0434

(2015) Stuart S. Winter et al.   PEDIATRIC BLOOD & CANCER

Synthesis and biological evaluation of a fatty acyl di-cytarabine prodrug

(2015) Feifei Li et al.   RSC Advances

An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation

(2014) Luqing Shang et al.   ANTIVIRAL RESEARCH

Induction of apoptosis in cervical cancer cells by the duplex drug 5-FdU–ECyd, coupling 2′-deoxy-5-fluorouridine and 3′-C-ethinylcytidine

(2014) Sarah Schott et al.   GYNECOLOGIC ONCOLOGY

Cytarabine-AOT catanionic vesicle-loaded biodegradable thermosensitive hydrogel as an efficient cytarabine delivery system

(2014) Jing Liu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Prophylactic treatment with the nucleoside analogue 2'-C-methylcytidine completely prevents transmission of norovirus

(2014) J. Rocha-Pereira et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

(2014) Travis K. Warren et al.   NATURE

Synthesis and antiviral evaluation of 4′-(1,2,3-triazol-1-yl)thymidines

(2014) Sanjeev Kumar V. Vernekar et al.   MedChemComm

Preclinical and Clinical Evaluation of Forodesine in Pediatric and Adult B-Cell Acute Lymphoblastic Leukemia

(2013) Kumudha Balakrishnan et al.   Clinical Lymphoma Myeloma & Leukemia

Design, synthesis, and biological evaluation of new 2′-deoxy-2′-fluoro-4′-triazole cytidine nucleosides as potent antiviral agents

(2013) Jie Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Sofosbuvir, a nucleotide polymerase inhibitor, for the treatment of chronic hepatitis C virus infection

(2013) David Alan Herbst et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Elacytarabine (CP-4055) in the treatment of acute myeloid leukemia

(2013) Courtney D DiNardo et al.   Future Oncology

Triazole–Dithiocarbamate Based Selective Lysine Specific Demethylase 1 (LSD1) Inactivators Inhibit Gastric Cancer Cell Growth, Invasion, and Migration

(2013) Yi-Chao Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting heat shock factor 1 with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer

(2012) Yi Xia et al.   CANCER LETTERS

Recent Researches in Triazole Compounds as Medicinal Drugs

(2012) C. -H. Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis, drug release and anti-HIV activity of a series of PEGylated zidovudine conjugates

(2012) Wenjun Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Phase 1 trial of gemtuzumab ozogamicin in combination with enocitabine and daunorubicin for elderly patients with relapsed or refractory acute myeloid leukemia: Japan Adult Leukemia Study Group (JALSG)-GML208 study

(2012) Yoshikazu Ito et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Discovery of a Novel Class of Potent and Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists

(2012) Mohamed A. Ibrahim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of duplex drugs linking 2′-deoxy-5-fluorouridine (5-FdU) with 3′-C-ethynylcytidine (ECyd) on hepatoblastoma cell lines

(2012) Carmen Eicher et al.   PEDIATRIC SURGERY INTERNATIONAL

Design, Synthesis, and In Vitro and In Vivo Biological Studies of a 3′-Deoxythymidine Conjugate that Potentially Kills Cancer Cells Selectively

(2012) Qiong Wei et al.   PLoS One

CMX001 (Hexadecyloxypropyl Cidofovir) Antiviral Activity against Adenovirus in Patients Correlates with Drug Levels and Viral Sensitivity

(2011) E.R. Lanier et al.   ANTIVIRAL RESEARCH

Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126

(2011) Auke D. Adema et al.   INVESTIGATIONAL NEW DRUGS

Inhibition of eIF4E with ribavirin cooperates with common chemotherapies in primary acute myeloid leukemia specimens

(2011) B C Kraljacic et al.   LEUKEMIA

Synthesis of 4′-Ethynyl-2′-deoxy-4′-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI

(2011) Kazuhiro Haraguchi et al.   ACS Medicinal Chemistry Letters

A novel nucleoside analog, 1-β-d-ribofuranosyl-3-ethynyl-[1,2,4]triazole (ETAR), exhibits efficacy against a broad range of flaviviruses in vitro

(2010) Michael McDowell et al.   ANTIVIRAL RESEARCH

Efficacy of 2′-C-methylcytidine against yellow fever virus in cell culture and in a hamster model

(2010) Justin G. Julander et al.   ANTIVIRAL RESEARCH

An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation

(2010) Vivian Wai Yan Lui et al.   BIOCHEMICAL PHARMACOLOGY

N-Aryltriazole ribonucleosides with potent antiproliferative activity against drug-resistant pancreatic cancer

(2010) Yang Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors

(2010) Hanane Elayadi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells

(2010) Menghua Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bitriazolyl acyclonucleosides synthesized via Huisgen reaction using internal alkynes show antiviral activity against tobacco mosaic virus

(2010) Menghua Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antitumor activity of novel 2′,3′-diethanethio-2′,3′,5′-trideoxy-5′-triazolonucleoside analogues

(2010) Jin-Lan Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tenofovir disoproxil fumarate in the treatment of chronic hepatitis B

(2010) Alice M Jenh et al.   Expert Review of Anti-Infective Therapy

Cytostatic activity of the duplex drug linking 2′-deoxy-5-fluorouridine (5FdU) with 3′-C-ethynylcytidine (ECyd) against gastric adenocarcinoma cell lines

(2010) Jürgen Weinreich et al.   INVESTIGATIONAL NEW DRUGS

3′-Deoxy Phosphoramidate Dinucleosides as Improved Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity

(2010) Stephane Priet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

(2010) Fraser F. Fleming et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clevudine for chronic hepatitis B: antiviral response, predictors of response, and development of myopathy

(2010) J.-H. Jang et al.   JOURNAL OF VIRAL HEPATITIS

Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?

(2010) Katherine L. B. Borden et al.   LEUKEMIA & LYMPHOMA

Ligand-Mediated Highly Effective and Selective C−N Coupling for Synthesizing BioactiveN-Aryltriazole Acyclonucleosides

(2010) Yuting Fan et al.   ORGANIC LETTERS

Synthesis and biological properties of pyrimidine 4′-fluoronucleosides and 4′-fluorouridine 5′-O-triphosphate

(2010) M. A. Ivanov et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Impact of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations P119S and T165A on 4'-Ethynylthymidine Analog Resistance Profile

(2009) G. Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Octadecyloxyethyl Ester of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy) Propyl]Adenine Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication in Genotype 1A, 1B, and 2A Replicons

(2009) D. L. Wyles et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiviral evaluation of octadecyloxyethyl esters of (S)-3-hydroxy-2-(phosphonomethoxy)propyl nucleosides against herpesviruses and orthopoxviruses

(2009) Nadejda Valiaeva et al.   ANTIVIRAL RESEARCH

Self-assembled drug delivery systems. Part 4. In vitro/in vivo studies of the self-assemblies of cholesteryl-phosphonyl zidovudine

(2009) Yiguang Jin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effect of (r)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) and AZT–lipid–PFA on human herpesvirus-6B infected cells

(2009) Karen Yao et al.   JOURNAL OF CLINICAL VIROLOGY

Discovery of Novel Arylethynyltriazole Ribonucleosides with Selective and Effective Antiviral and Antiproliferative Activity

(2009) Jinqiao Wan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Triazole Ribonucleoside Down-Regulates Heat Shock Protein 27 and Induces Potent Anticancer Activity on Drug-Resistant Pancreatic Cancer

(2009) Yi Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intravenous administration of CP-4055 (ELACYT™) in patients with solid tumours. A phase I study

(2008) Svein Dueland et al.   ACTA ONCOLOGICA

Phase I study of troxacitabine administered by continuous infusion in subjects with advanced solid malignancies

(2008) A. Jimeno et al.   ANNALS OF ONCOLOGY

Synthesis of 1-β-d-ribofuranosyl-3-ethynyl-[1,2,4]triazole and its in vitro and in vivo efficacy against Hantavirus

(2008) Dong-Hoon Chung et al.   ANTIVIRAL RESEARCH

Nucleosides and oligonucleotides containing 1,2,3-triazole residues with nucleobase tethers: Synthesis via the azide-alkyne ‘click’ reaction

(2008) Padmaja Chittepu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication

(2008) Ruizhi Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evolution of decitabine development

(2008) Elias Jabbour et al.   CANCER

Antitumoral activity of PEG–gemcitabine prodrugs targeted by folic acid

(2008) Gianfranco Pasut et al.   JOURNAL OF CONTROLLED RELEASE

Phosphoramidate Dinucleosides as Hepatitis C Virus Polymerase Inhibitors

(2008) Ivan Zlatev et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pradefovir: A Prodrug That Targets Adefovir to the Liver for the Treatment of Hepatitis B

(2008) K. Raja Reddy et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Polymer Supported Approach to Nucleoside Modification

(2008) Suyeal Bae et al.   JOURNAL OF ORGANIC CHEMISTRY

Nucleoside analogs: molecular mechanisms signaling cell death

(2008) B Ewald et al.   ONCOGENE

Bitriazolyl acyclonucleosides with antiviral activity against tobacco mosaic virus

(2008) Wei Li et al.   TETRAHEDRON LETTERS

Self-assembled drug delivery systems

(2007) Yiguang Jin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS