Article
Biochemistry & Molecular Biology
Anna Clua, Carme Fabrega, Jesus Garcia-Chica, Santiago Grijalvo, Ramon Eritja
Summary: This study proposes a new strategy to deliver 5-FdU using G-quadruplex nanostructures, which increase its cytotoxic effect in FU-resistant colorectal cancer cells.
Article
Chemistry, Physical
Daiki Nonoshita, Wataru Kashihara, Kazuhito Tanabe, Tasuku Isozaki, Yao Zhong Xu, Tadashi Suzuki
Summary: A novel thio-2'-deoxyuridine derivative with red-shifted absorption band and fluorescence properties was successfully synthesized, showing high quantum yield values under low oxygen concentrations. These findings are significant for the development of thio-2'-deoxyribonucleoside-based pharmaceuticals as DNA-specific photosensitizers for photochemotherapy.
JOURNAL OF PHYSICAL CHEMISTRY A
(2021)
Article
Fisheries
Hairong Lian, Rumeng Li, Yanchao Chai, Yu Zhang, Yurong Lu, Zihan Pan, Rui Zhang, Jiaxin Yang, Cui Han
Summary: The effects of 5-fluoro-2'-deoxyuridine (FUdR) on the development of rotifers and the growth of Spirulina platensis were investigated. It was found that FUdR had dose-dependent negative effects on the reproduction and egg hatching of rotifers, but did not significantly affect the growth and nutritional composition of S. platensis. Therefore, FUdR has the potential to control grazing zooplankton contamination in microalgal cultivation.
AQUACULTURE RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Oliver Fischer, Markus R. Heinrich
Summary: 2-fluoro-5-nitrophenyldiazonium tetrafluoroborate is a novel Sanger-type reagent that enables the versatile functionalization of primary and secondary aliphatic alcohols. The diazonium unit on the resulting aryl-alkyl ether can be used for diverse transformations such as radical C-H activation, cyclization, and palladium catalyzed cross-coupling reactions, based on mild nucleophilic aromatic substitution under unprecedented, base-free conditions.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Physical
Sandip Porey, Yogesh Bairagi, Srimanta Guin, Xinglong Zhang, Debabrata Maiti
Summary: Fluorinated entities are highly valued in medicinal chemistry due to their enhanced bioactivity. This article presents a non-directed strategy for the regioselective synthesis of α-fluoro olefins using palladium-catalyzed C-H/C-F coupling. The method allows for late-stage derivatization of drugs and natural products, and provides a way to conjugate drugs with natural products through a fluoro-olefin bridge.
Article
Biochemistry & Molecular Biology
Marek Krol, Grzegorz Slifirski, Jerzy Kleps, Szymon Ulenberg, Mariusz Belka, Tomasz Baczek, Agata Siwek, Katarzyna Stachowicz, Bernadeta Szewczyk, Gabriel Nowak, Beata Duszynska, Franciszek Herold
Summary: Novel compounds with high affinities for 5-HT1A receptor were synthesized and characterized through a series of experiments, showing potential for therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Mahmoud Kandeel, Abdulla Al-Taher
Summary: The decoding of genome sequences of camel and its pathogens can accelerate the discovery of new drug targets. In this study, differences in dUTPase enzymes between dromedary camels and Trypanosoma evansi were investigated, revealing potential for dUTPase as a useful target for anti-Trypanosoma drug discovery research due to structural and catalytic differences.
PAKISTAN VETERINARY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Heiko M. Lesslich, Lars Klapal, Justus Wilke, Annika Haak, Irmgard D. Dietzel
Summary: Cell culture studies offer a unique opportunity to investigate the effects of pharmacological treatments on various aspects of cell behavior. In this study, the researchers explored the use of 5-fluoro-2'-deoxyuridine (FUdR) as a substitute for cytosine arabinoside (AraC) as a glia proliferation inhibitor. They found that FUdR led to a higher ratio of neurons to glia cells compared to AraC, and there was no difference in the amplitudes of voltage-gated Na+ currents in neurons treated with FUdR.
Article
Chemistry, Physical
Zakir Ullah, Bilal Mustafa, Hyun Jee Kim, Y. Sheena Mary, Y. Shyma Mary, Hyung Wook Kwon
Summary: In this study, DFT calculations were used to investigate the adsorption properties of OPC on four fullerene-like nanocages. Various calculations were performed to analyze the relaxed structures of adsorbed OPC on each nanocage. The results show that OPC forms a bond with the nanocage through the interaction between its nucleophilic and electrophilic parts. Additionally, boron-containing nanocages are suggested to be superior drug sensors compared to aluminum-containing nanocages due to their larger fluctuations in bandgap.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Organic
Yan-Ying Zhu, Hui-Bei Xu, Jing Zhang, Yi Luo, Lin Dong
Summary: Fluorinated compounds are widely used in agrochemicals, pharmaceuticals, and biochemical sciences. In this study, an efficient Ru(II)-catalyzed site-selective C-H functionalization/difluoromethylated reaction was developed to synthesize 3-difluoromethylated and remote meta-difluoromethylated 7-azaindole derivatives separately.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Jingwen Yuan, Shahid Ullah Khan, Junfeng Yan, Jiatong Lu, Chen Yang, Qiang Tong
Summary: Baicalin inhibits gastric cancer and enhances the efficacy of 5-Fu by promoting ROS-related ferroptosis in gastric cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Aichun Li, Qin Yang, Guohua Lou, Yanning Liu, Hongguang Xia, Zhi Chen
Summary: In this study, F-nec was identified as a novel potent RIP1 inhibitor that efficiently blocked TNF-alpha-induced necroptosis in human and mice cells. Pre-treatment with F-nec prevented hepatic necrosis and attenuated LPS/GalN-induced acute liver failure by suppressing JNK-triggered inflammation, highlighting its potential for use in the treatment of inflammatory liver diseases driven by RIP1.
Article
Chemistry, Medicinal
Pierre-Yves Geant, Malika Kaci, Jean-Pierre Uttaro, Christian Perigaud, Christophe Mathe
Summary: In this study, the racemic synthesis of 3'-fluoro-5'-norcarbocyclic nucleoside phosphonates was reported, and the antiviral activities of the enantiomers were evaluated. The results show that the bis(POM) prodrug (-)-9 exhibits similar or even superior activities compared to (R)-PMPA.
Article
Biochemistry & Molecular Biology
Jing Hong, Zhen Feng
Summary: A novel combination therapy for gastric cancers using SN-38 and 5FU encapsulated in nanoparticles shows improved efficacy in stabilizing the tumor microenvironment and inducing apoptosis in gastric cells. The study suggests that this dual drug delivery approach has the potential to enhance the effectiveness of gastric cancer therapy.
PROCESS BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Aneta Grabarska, Jarogniew J. Luszczki, Kinga Gawel, Wirginia Kukula-Koch, Malgorzata Juszczak, Adrianna Slawinska-Brych, Grzegorz Adamczuk, Magdalena Dmoszynska-Graniczka, Nataliia Kosheva, Wojciech Rzeski, Andrzej Stepulak
Summary: The study found that magnoflorine has anticancer effects against gastric cancer cells by inhibiting proliferation and inducing apoptosis. Combination treatment with docetaxel produced additional pharmacological interaction. Moreover, there was no observed toxicity of magnoflorine in a zebrafish model. These findings provide a foundation for the potential therapeutic use of magnoflorine in gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Christoph Engel, Christine Fischer, Silke Zachariae, Karolin Bucksch, Kerstin Rhiem, Jutta Giesecke, Natalie Herold, Barbara Wappenschmidt, Verena Huebbel, Monika Maringa, Simone Reichstein-Gnielinski, Eric Hahnen, Claus R. Bartram, Nicola Dikow, Sarah Schott, Dorothee Speiser, Denise Horn, Eva M. Fallenberg, Marion Kiechle, Anne S. Quante, Anne-Sophie Vesper, Tanja Fehm, Christoph Mundhenke, Norbert Arnold, Elena Leinert, Walter Just, Ulrike Siebers-Renelt, Stefanie Weigel, Andrea Gehrig, Achim Woeckel, Brigitte Schlegelberger, Stefanie Pertschy, Karin Kast, Pauline Wimberger, Susanne Briest, Markus Loeffler, Ulrich Bick, Rita K. Schmutzler
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ferdinand Zimmermann, Andreas Korzowski, Johannes Breitling, Jan-Eric Meissner, Patrick Schuenke, Lisa Loi, Moritz Zaiss, Sebastian Bickelhaupt, Sarah Schott, Heinz-Peter Schlemmer, Daniel Paech, Mark E. Ladd, Peter Bachert, Steffen Goerke
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Oncology
Annika Funk, Joerg Heil, Aba Harcos, Christina Gomez, Anne Stieber, Hans Junkermann, Andre Hennigs, Geraldine Rauch, H. -P. Sinn, Fabian Riedel, Benedikt Schaefgen, Sarah Hug, Anna Maier, Maria Blumenstein, Christoph Domschke, Sarah Schott, Markus Wallwiener, Joachim Rom, Florian Schuetz, Christof Sohn, Michael Golatta
BREAST CANCER RESEARCH AND TREATMENT
(2020)
Review
Oncology
Kerstin Rhiem, Bernd Auber, Susanne Briest, Nicola Dikow, Nina Ditsch, Neda Dragicevic, Sabine Grill, Eric Hahnen, Judit Horvath, Bernadette Jaeger, Karin Kast, Marion Kiechle, Elena Leinert, Susanne Morlot, Michael Puesken, Dieter Schaefer, Sarah Schott, Christopher Schroeder, Ulrike Siebers-Renelt, Christine Solbach, Nana Weber-Lassalle, Isabell Witzel, Christine Zeder-Goess, Rita K. Schmutzler
Summary: The GC-HBOC has established a multigene panel for the analysis of familial breast and ovarian cancer risk genes. An interdisciplinary team of experts evaluated data on risk modification in the presence of pathogenic mutations to provide clinical recommendations for patient counseling and care at GC-HBOC centers. The goal is to better assess individual disease risk and recommend risk-adapted preventive/therapeutic measures.
Meeting Abstract
Psychiatry
Agnieszka Czisch, Janina Kant, Sarah Schott, Monika Keller
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Oncology
Nathalie Rippinger, Christine Fischer, Hans-Peter Sinn, Nicola Dikow, Christian Sutter, Kerstin Rhiem, Sabine Grill, Friedrich W. Cremer, Huu P. Nguyen, Nina Ditsch, Karin Kast, Simone Hettmer, Christian P. Kratz, Sarah Schott
Summary: Women with Li-Fraumeni syndrome have a higher risk of developing aggressive subtypes of breast cancer at a young age. Optimal treatment strategies, such as breast-conserving surgery or mastectomy, may prolong time to a second breast cancer diagnosis in this population. Further research is needed to determine long-term survival benefits and individual tumor risks.
Article
Oncology
Aoife Ward Gahlawat, Lavinia Fahed, Tania Witte, Sarah Schott
Summary: This study suggests that total cf-miRNA levels in the blood can be used as an independent prognostic marker for breast cancer, correlating with unfavorable clinical features and cancer relapse.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Aoife Ward Gahlawat, Tania Witte, Lisa Haarhuis, Sarah Schott
Summary: This study highlights the potential of cf-miRNA levels and individual cf-miRNAs for the diagnosis and prognosis of ovarian cancer.
BRITISH JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Aoife Ward Gahlawat, Tania Witte, Peter Sinn, Sarah Schott
Summary: Ovarian cancer is an aggressive disease with low survival rates. Liquid biopsy markers, specifically cf-miRNAs, show potential as an independent prognostic factor for survival. Upregulation of miR-200c and miR-141 in both plasma and tissues of OC patients correlates with adverse clinical features. cf-miRNAs are more easily obtained and stable in blood, making them a suitable liquid biopsy marker for OC.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Juliane Nees, Farina Struewe, Sarah Schott
Summary: Individuals with cancer predisposition syndromes (CPS) inherit elevated cancer risks. Medical supply gaps for people at risk of CPS cause insufficient outreach and miss potential benefits of individualized care strategies. Increased awareness of CPS and progress in the eHealth sector are untapped sources of health care improvement for affected individuals. Medical teaching on cancer predisposition syndromes should be expanded to improve knowledge and individualized and personalized healthcare.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Oncology
Juliane Nees, Senta Kiermeier, Farina Struewe, Myriam Keymling, Imad Maatouk, Christian P. Kratz, Sarah Schott
Summary: The study investigated the dietary patterns, physical activity, quality of life, and perception of cancer risk among TP53 pathogenic variant carriers and their relatives. Results showed that women and pathogenic variant carriers tended to have healthier diets and smoke less, but men had better psychological well-being. Carriers perceived a higher personal cancer risk.
Meeting Abstract
Obstetrics & Gynecology
A. Schuhn, J. Nees, A. Gahlawat, T. Witte-Tobar, D. Weber, J. G. Okun, S. Schott
GEBURTSHILFE UND FRAUENHEILKUNDE
(2020)
Meeting Abstract
Obstetrics & Gynecology
J. Nees, S. Kiermeier, I Maatouk, S. Schott
GEBURTSHILFE UND FRAUENHEILKUNDE
(2020)
Article
Public, Environmental & Occupational Health
Stephanie C. Joachim, Diane Bitzinger, Hannah Arnold, Johannes Lermann, Thekla H. Oechtering, Sarah Schott, Kevin Schulte, Matthias Raspe
Meeting Abstract
Oncology
Kerstin Rhiem, Sarah Schott, Dorothee Speiser, Joke Tio, Marion Kiechle, Susanne Briest, Anne-Sophie Vesper, Karin Kast, Marion von Mackeienbergh, Elena Leinert, Christoph Engel, Rita K. Schmutzler
ONCOLOGY RESEARCH AND TREATMENT
(2020)