Article
Multidisciplinary Sciences
Michael C. Sneller, Jana Blazkova, J. Shawn Justement, Victoria Shi, Brooke D. Kennedy, Kathleen Gittens, Jekaterina Tolstenko, Genevieve McCormack, Emily J. Whitehead, Rachel F. Schneck, Michael A. Proschan, Erika Benko, Colin Kovacs, Cihan Oguz, Michael S. Seaman, Marina Caskey, Michel C. Nussenzweig, Anthony S. Fauci, Susan Moir, Tae-Wook Chun
Summary: The combination therapy with broadly neutralizing monoclonal antibodies can provide long-term virological suppression without antiretroviral therapy in individuals with HIV. This study offers guidance for future clinical trials involving next-generation antibodies with long half-lives.
Article
Pharmacology & Pharmacy
Yanqing Wang, Weijuan Huang, Nannan Wang, Defang Ouyang, Lifeng Xiao, Sirui Zhang, Xiaozheng Ou, Tingsha He, Rongmin Yu, Liyan Song
Summary: The study successfully developed AB long sustained-release microspheres with low burst release and stable release properties within a week. Both in vitro and in vivo studies demonstrated excellent anti-tumor activity and low toxicity of ABMs, showing great potential for clinical applications.
Article
Pharmacology & Pharmacy
Pere Fontova, Helena Colom, Raul Rigo-Bonnin, Oriol Bestard, Anna Vidal-Alabro, Lisanne N. van Merendonk, Gema Cerezo, Carolina Polo, Nuria Montero, Edoardo Melilli, Anna Manonelles, Maria Meneghini, Ana Coloma, Josep M. Cruzado, Joan Torras, Josep M. Grinyo, Nuria Lloberas
Summary: Tacrolimus is considered a key calcineurin inhibitor in transplantation, with the extended-release Meltdose formulation exhibiting superior bioavailability compared to the immediate-release formulation. This study aimed to compare the pharmacodynamic/pharmacokinetic profiles of Tac-IR and Tac-LCP and found that despite higher peak plasma concentrations after Tac-IR, it did not result in stronger inhibition of calcineurin activity compared to Tac-LCP. Tac-LCP demonstrated more sustained inhibition of calcineurin activity between dose intervals, suggesting potential improvement in the pharmacodynamics of Tacrolimus.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Plant Sciences
Satomi Miura, Kotaro Ishida, Kazuaki Tanaka, Eiji Morita, Masaru Hashimoto
Summary: Five integrasone derivatives were isolated from Lepteutypa sp. KT4162 culture broth. The relative configuration of the 1,4-epoxydiol moiety was determined using calculated nJCH values and HMBC spectra, while the absolute configurations were determined using DFT-based ECD spectral analysis. Compound 2 showed potent inhibition of HIV-1 integrase with no cytotoxicity.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Medicinal
Qianmeng Lin, Xuan Xia, Jun Li, Zhan Zhou, Yongheng Chen
Summary: The study developed a site-specific N-terminal PEGylation method and successfully constructed two homogeneous mPEG-GLP-1 peptides. After PEGylation, degradation decreased, pharmacokinetic performance improved, and hypoglycemic effects were enhanced. This method achieved better pharmacological and therapeutic properties through site-specific modification.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Bwalya A. Witika, Jesse-Clint Stander, Vincent J. Smith, Roderick B. Walker
Summary: Combining lamivudine and zidovudine in a nano co-crystal form within a suitable hydrogel carrier exhibit improved toxicity profiles and sustained drug release. Stimuli-responsive delivery systems offer an opportunity to control and prolong drug delivery, reducing issues with medication adherence.
Review
Pharmacology & Pharmacy
Justin C. Merritt, Stephen D. Richbart, Emily G. Moles, Ashley J. Cox, Kathleen C. Brown, Sarah L. Miles, Paul T. Finch, Joshua A. Hess, Maria T. Tirona, Monica A. Valentovic, Piyali Dasgupta
Summary: Capsaicin, a phytochemical found in chili peppers, exhibits potent anti-cancer activity. However, its clinical application is hindered by poor bioavailability, aqueous solubility, and adverse side effects. Encapsulation of capsaicin in sustained release drug delivery systems can overcome these challenges, leading to improved solubility, stability, bioavailability, and reduced side effects. These capsaicin-based formulations have the potential to serve as novel chemotherapies, diagnostic imaging probes, and chemosensitization agents for human cancers.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Instruments & Instrumentation
Hao Yuan, Zhengyu Zhang, Liandong Hu
Summary: In this study, a new gastro-floating sustained-release capsule (GFC) containing levodopa (LD) and benserazide hydrochloride (BH) was successfully developed. The GFCs showed a better sustained-release effect and higher bioavailability compared to commercial tablets.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Miriam E. Klein, Max Rieckmann, Daniel Sedding, Gerd Hause, Annette Meister, Karsten Maeder, Henrike Lucas
Summary: Anionic phospholipids phosphatidylserine (PS) and phosphatidylglycerol (PG) have anti-inflammatory and immunomodulatory activities, but PEGylation of PS and PG liposomes did not effectively prolong circulation time and led to increased uptake in the spleen.
Article
Chemistry, Medicinal
Duanduan Cong, Wenyuan Qi, Xiaohui Liu, Xiaoyu Xu, Lingyun Dong, Wei Xue, Kexin Li
Summary: This study aimed to compare the pharmacokinetic characteristics of enteric-coated sustained-release (EcSr) aspirin tablets with enteric-coated (Ec) aspirin tablets in healthy Chinese participants. The results showed that EcSr aspirin tablets had less inter-individual variation in release and absorption, and meals had no significant effect on their pharmacokinetics.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Nguyen-Thach Tung, Thi-Hoang-Yen Dong, Cao-Son Tran, Thi-Kim-Thuy Nguyen, Sang-Cheol Chi, Danh-Son Dao, Dang-Hoa Nguyen
Summary: This study aimed to optimize the nanocrystal formulation to enhance the solubility of a poorly soluble drug and modify its release profile by integrating a fast-release phase and a sustained-release phase in a compression-coated tablet. The results showed that the optimized nanocrystal formulation and different derivatives of HPMC improved the drug release behavior.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Sijie Wu, Gaodan Liu, Ping Shao, Xingyu Lin, Jiahao Yu, Hanchi Chen, Huiliang Li, Simin Feng
Summary: This study developed a carboxymethyl-modified chitosan/hyaluronic acid thermosensitive hydrogel for sustained transdermal delivery of liposomes. The hydrogel exhibited suitable gel properties and structure, resulting in delayed liposomes release and improved skin retention. The liposome-hydrogel system more efficiently promoted the effects of anti-aging agents on the skin.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Zhijun Cao, Xing Tang, Yu Zhang, Tian Yin, Jingxin Gou, Yanjiao Wang, Haibing He
Summary: The study introduces a solvent-exchange in-situ depot system that incorporates progesterone-loaded PLGA nanoparticles into a matrix of SAIB and PLGA, for long-term treatment in Assisted Reproductive Technology. Results show that different solvents and PLGA contents can affect the drug release rate of the system. In vivo experiments demonstrate higher drug concentration and AUC over the testing period compared to commercial solutions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Niloofar Savadkouhi, Peyman Salehi, Houri Sepehri, Ladan Delphi, Hasan Rafati
Summary: In this study, PEGylated derivatives of noscapine with enhanced solubility were synthesized and their anticancer activities were evaluated. The results showed that increasing the PEG chain length improved the water solubility and cytotoxicity of the derivatives. These new PEGylated compounds may have the potential to be developed as novel anticancer drugs.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Nanoscience & Nanotechnology
Shanshan Zhao, Wenying Dong, Yilong Wang, Xingyu Zhou, Junhui Jiang, Ruibo Hu, Tong Lin, Dahui Sun, Mei Zhang
Summary: In this study, a multifunctional zinc ion sustained-release biocoating was developed to address the bioinert surface of carbon fiber-reinforced polyetheretherketone (CFRPEEK) orthopedic implants. The biocoating showed the ability to regulate immune inflammatory response, promote angiogenesis, and accelerate osseointegration. In vitro assessments demonstrated the significant effects of the biocoating on immune response, oxidative stress level, angiogenesis, and osteogenic differentiation. Animal experiments confirmed the enhanced structural and mechanical properties of bones with the biocoating. This study offers an attractive strategy for the clinical application of inert implants.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Qingqing Hao, Xu Ling, Christophe Pannecouque, Erik De Clercq, Fener Chen
Summary: A novel series of CHOR-HEPT non-nucleoside HIV-1 reverse transcriptase inhibitors were developed based on structure-based design strategy, using compound 6 as the starting point. These compounds showed moderate to good activity against wild-type HIV-1 strain, with EC50 values ranging from 0.18 to 51.88 mu mol/L and SI values ranging from 4 to 907. Compound 14aj with a CHOH linker and compound 13i with a CHOTMS linker exhibited improved anti-HIV-1 activity (EC50 = 0.18 mu mol/L and 0.20 mu mol/L) and higher selectivity (SI = 907 and 665) compared to the lead compound 6 (EC50 = 0.59 mu mol/L, SI = 9).
CHINESE CHEMICAL LETTERS
(2023)
Article
Microbiology
Cong-Jian Li, Zhen Zhang, Peng-Chao Zhan, Ai-Ping Lv, Pan-Pan Li, Lan Liu, Wen-Jun Li, Ling-Ling Yang, Xiao-Yang Zhi
Summary: In this study, nine endophytic strains belonging to the genus Clostridium sensu stricto, including three new species, were isolated from the roots of Paris polyphylla Smith var. yunnanensis. These endophytic strains exhibited diversity in fermentation products, and their genomes showed subtle changes associated with environmental adaptations compared to non-endophytic strains. Therefore, the new species Clostridium yunnanense sp. nov., Clostridium rhizosphaerae sp. nov., and Clostridium paridis sp. nov. are proposed based on strains YIM B02505T, YIM B02515T, and YIM B02565T, respectively.
Article
Fisheries
Chong Han, Wenwei Huang, Suhan Peng, Jiangwei Zhou, Huawei Zhan, Lin Gui, Wenjun Li, Qiang Li
Summary: By whole genome sequencing of Spinibarbus hollandi, three male-specific markers were identified and validated, showing 100% accuracy in another 24 female and 24 male individuals. Additionally, several male-specific genes involved in sex determination were identified through NR annotation. The male-specific markers suggest an XY sex determination system in S. hollandi and contribute to understanding sex determination mechanisms and development of unisexual breeding.
Article
Microbiology
Hua-Peng Xue, Zi-Yue Fu, Wei He, Lei Wang, Wen-Jun Li, Ai Hua Zhang, Jian-Ke Huang, Dao-Feng Zhang, Zhe Zhao
Summary: A new species of genus Paracoccus, named Paracoccus marinaquae sp. nov., was isolated from the coastal water of the Yellow Sea, China. This bacterium is Gram-stain-negative, non-motile and coccoid. It grows at a temperature range of 20-37 degrees C, pH range of 5.0-9.0, and NaCl concentration range of 0-7.0%. Based on phylogenetic analysis and phenotypic characteristics, it was determined to be a novel species within the genus Paracoccus.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shenghua Gao, Letian Song, Yusen Cheng, Fabao Zhao, Dongwei Kang, Shu Song, Mianling Yang, Bing Ye, Wei Zhao, Yajie Tang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Summary: The study found that Indolylarylsulfones (IASs) have potent antiviral activity against HIV-1 but high cytotoxicity. To address this issue, researchers synthesized a compound called R10L4 with reduced cytotoxicity and significant inhibitory activity against wild-type and mutant strains of HIV-1. The results suggest that R10L4 may be a promising non-nucleoside reverse transcriptase inhibitor.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Microbiology
Jin Zheng, Jie-Liang Liang, Pu Jia, Shi-wei Feng, Jing-li Lu, Zhen-hao Luo, Hong-xia Ai, Bin Liao, Jin-tian Li, Wen-sheng Shu
Summary: This study used genome-resolved metagenomics to reveal the vast phylogenetic and metabolic diversities of putative MeHg producers and degraders in AMD sediments. The diversity of MeHg-metabolizing microorganisms (particularly MeHg degraders) in AMD sediments is much higher than previously recognized. Microbial and abiotic factors affecting MeHg accumulation in AMD sediments were identified using multiple linear regression analysis. This work emphasizes the importance of using genome-resolved metagenomics to survey MeHg-metabolizing microorganisms and provides a framework for understanding the microbial basis of MeHg accumulation.
Article
Agriculture, Dairy & Animal Science
Chong Han, Wenwei Huang, Suhan Peng, Jiangwei Zhou, Huawei Zhan, Yuying Zhang, Wenjun Li, Jian Gong, Qiang Li
Summary: This study obtained the gonad transcriptomes of S. hollandi using Illumina Novaseq technology and compared the transcriptome differences between the ovaries and testes. A large number of differentially expressed genes participated in reproduction, gonad formation and differentiation, and gametogenesis. These findings can provide valuable insights into the regulatory functions of sex-related genes in S. hollandi.
Article
Microbiology
Wenkai Teng, Bin Liao, Mengyun Chen, Wensheng Shu
Summary: GC content is an important factor in microbial ecology and evolution, and the genomic GC of bacteria is characterized by heterogeneity between genomes, homogeneity within genomes, strong phylogenetic inertia, and association with the environment. Current hypotheses regarding direct selection or mutational biases cannot explain these features simultaneously. This study provides evidence that ancient adaptations have transformed the DNA replication and repair system, resulting in mutational biases that contribute to a bimodal distribution of genomic GC. This highlights the importance of indirect effects of natural selection in bacterial evolution.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Qing-Qing Hao, Xiao-Mei Chen, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen
Summary: In the pursuit of more potent HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs), we have developed a series of novel HEPTs compounds. Among them, compound C20 showed the highest potency and selectivity, and demonstrated good efficacy against clinically relevant mutant strains, laying the foundation for further improvement on the HEPT scaffold.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Ya-Li Sang, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen
Summary: A series of novel biphenyl-DAPY derivatives were developed using the fragment-hopping strategy to enhance the anti-resistance efficacy of a non-nucleoside reverse transcriptase inhibitor (NNRTI). Most of the compounds exhibited improved anti-HIV-1 potency, with compound 8r showing exceptional potency against wild-type HIV-1 and mutant strains. The new DAPY analogue had lower cytotoxicity, higher selectivity index, and favorable pharmacokinetic properties, making it a potential candidate for HIV treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xiangyi Jiang, Boshi Huang, Shawn Rumrill, David Pople, Waleed A. Zalloum, Dongwei Kang, Fabao Zhao, Xiangkai Ji, Zhen Gao, Lide Hu, Zhao Wang, Minghui Xie, Erik De Clercq, Francesc X. Ruiz, Eddy Arnold, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Summary: The authors developed a series of piperazine sulfonyl-bearing diarylpyrimidine-based non-nucleoside reverse transcriptase inhibitors (NNRTIs) that have improved potency against HIV-1 by enhancing backbone-binding interactions. Compound 18b1 demonstrated high potency against multiple strains of HIV-1, including drug-resistant strains, and showed better pharmacokinetic properties compared to currently approved NNRTIs. This compound is considered a potential lead compound for further study.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Xiangyi Jiang, Boshi Huang, Waleed A. Zalloum, Chin-Ho Chen, Xiangkai Ji, Zhen Gao, Jiaojiao Dai, Minghui Xie, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Summary: Novel diarypyrimidine derivatives were designed based on previously reported HIV-1 NNRTIs BH-11c and XJ-10c to improve antiresistance and drug-like profiles. Compound 12g showed the highest inhibitory activity against wild-type and NNRTI-resistant HIV-1 strains, with EC50 values ranging from 0.024 to 0.0010 μM. Its improved antiresistance profile compared to ETR was explained by MD simulation study and it also showed improved water solubility and other drug-like properties. Compound 12g exhibited promising pharmacokinetics parameters and could be a potential lead compound for new antiretroviral drug development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Hao Song, Yu Xia, Tao Zhang, Caiyun Dun, Bairu Meng, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Summary: In order to develop more effective HIV-1 inhibitors against various NNRTIs-resistant strains, a series of 5-cyano substituted diarylpyridines were designed based on cocrystal structural analysis. Among them, compound I-5b exhibited the highest potency (EC50 = 5.62-171 nM) against wild-type and mutant HIV-1 strains. Particularly for the K103 N strain, I-5b showed exceptional activity with an EC50 value of 9.37 nM, surpassing NVP (EC50 = 5128 nM) and EFV (EC50 = 114 nM), and comparable to ETR (EC50 = 3.45 nM). Furthermore, all compounds were found to target HIV-1 RT with moderate RT enzyme inhibitory activity (IC50 = 0.094-12.0 & mu;M). The binding mode of representative compounds with RT was elucidated through molecular docking.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Li -Min Zhao, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen -Er Chen
Summary: This study identified a series of novel heterocycle-substituted ATDP derivatives with significantly improved selectivity and solubility by replacing the biphenyl moiety of ZLM-66 with a heterocyclic group of lower lipophilicity. Among these derivatives, the representative analog 7w exhibited dramatically enhanced selectivity and solubility compared to ZLM-66. The analog showed low nanomolar inhibition of wild-type HIV-1 strain and tested mutant strains, as well as favorable safety and pharmacokinetic profiles.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
