Article
Chemistry, Medicinal
Anastasiya S. Sokolova, Kseniya S. Kovaleva, Olga Yarovaya, Nikolay Bormotov, Larisa N. Shishkina, Olga A. Serova, Alexander A. Sergeev, Alexander P. Agafonov, Rinat A. Maksuytov, Nariman F. Salakhutdinov
Summary: Despite the eradication of smallpox, related viruses could still be used as bioterrorist weapons or re-emerge naturally. This study evaluated the antiviral activity of certain compounds against various poxviruses, with some showing significant effectiveness against orthopoxviruses.
ARCHIV DER PHARMAZIE
(2021)
Article
Chemistry, Medicinal
Petra Brehova, Ema Chaloupecka, Michal Cesnek, Jan Skacel, Martin Dracinsky, Eva Tloustova, Helena Mertlikova-Kaiserova, Monica P. Soto-Velasquez, Val J. Watts, Zlatko Janeba
Summary: A series of novel acyclic nucleoside phosphonates (ANPs) were synthesized and evaluated as potential adenylate cyclase inhibitors, showing promising inhibitory effects on various toxins and enzymes. Some compounds were identified as potential leads for the treatment of human inflammatory and neuropathic pain.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Ryan C. Bruneau, Loubna Tazi, Stefan Rothenburg
Summary: In this article, we review the history of the evolution of cowpox viruses (CPXVs) and their broad host range, lethal outbreaks, and increasing human cases in Eurasian countries. Genetic analyses have revealed multiple Orthopoxvirus species categorized under CPXV designation. We discuss modern outbreaks in zoos, domesticated animals, and humans, including the pathogenesis, geographic range, and molecular level interactions. The potential threat of these viruses and the future of CPXV research are also discussed to provide a comprehensive review of CPXVs.
Article
Chemistry, Medicinal
Karolina Vankova, Eva Dolezelova, Eva Tloustova, Dana Hockova, Alena Zikova, Zlatko Janeba
Summary: A series of novel 7-aryl-7-deazaadenine-based N-branched acyclic nucleoside phosphonates (aza-ANPs) were synthesized using the optimized Suzuki cross-coupling reaction. Compound 14h, which contains two phosphonate moieties, showed potent anti-trypanosomal activity and low micromolar cytotoxicity against leukemia and/or cancer cell lines.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Pavel Kraina, Michal Cesnek, Eva Tloustova, Helena Mertlikova-Kaiserova, Camryn J. Fulton, Emily K. Davidson, Brenton P. Smith, Val J. Watts, Zlatko Janeba
Summary: A series of novel 7-substituted 7-deazaadefovir analogues were synthesized, and 12 of them were found to be single-digit micromolar inhibitors of Bordetella pertussis adenylate cyclase toxin. Compound 14 was identified as a potent, non-toxic, and selective mAC2 inhibitor.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Alan Ford, Nicholas D. Mullins, Jan Balzarini, Anita R. Maguire
Summary: A variety of lipophilic prodrugs of alpha-carboxy nucleoside phosphonates were synthesized and evaluated for their potency against HIV in cell culture. One prodrug exhibited some activity, while others were found to be inactive.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Virology
Rebecca A. Morgis, Kaylyn Haan, Julie M. Schrey, Rosie M. Zimmerman, Adam R. Hersperger
Summary: This study examined the relationship between ectromelia growth factor (ECGF) and vaccinia growth factor (VGF), finding that despite structural differences, both proteins possess the six conserved cysteine residues crucial for EGF function, with ECGF acting as a mitogen in a similar manner as VGF.
Article
Chemistry, Medicinal
Michal Cesnek, Michal Safranek, Martin Dracinsky, Eva Tloust'ova, Helena Mertlikova-Kaiserova, Michael P. Hayes, Val J. Watts, Zlatko Janeba
Summary: A series of potent acyclic nucleoside phosphonates (ANPs) were designed as inhibitors of bacterial ACs, showing substantial selectivity and significant inhibitory effects in cell-based and cell-free assays. These compounds represent the most effective ACT/EF inhibitors based on ANPs reported to date.
Review
Microbiology
Sian Lant, Carlos Maluquer de Motes
Summary: This review highlights the crucial role of the ubiquitin system in regulating cellular functions and combating viral infections, as well as the strategies utilized by viruses to manipulate this system. Understanding the interactions between the ubiquitin system and viruses can lead to the discovery of new antiviral treatments and insights into viral pathogenesis and host responses.
Review
Biochemistry & Molecular Biology
Simon Verdonck, Josephine Nemegeer, Peter Vandenabeele, Jonathan Maelfait
Summary: Cell death, including necroptosis and pyroptosis, is an important part of the antiviral immune response, eliminating virus-infected cells and promoting immune development through the release of inflammatory mediators. Viruses employ evasion mechanisms to suppress these cell death pathways and antagonize host immunity.
TRENDS IN MICROBIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Marcela Krecmerova, Pavel Majer, Rana Rais, Barbara S. Slusher
Summary: This review focuses on biologically active phosphonates used in various biomedical applications. The synthesis and modification of prodrugs are discussed, as well as the potential of these compounds in treating viral infections.
FRONTIERS IN CHEMISTRY
(2022)
Article
Virology
Nikita Ushkalenko, Anna Ersh, Alexander Sergeev, Pavel Filatov, Alexander Poltavchenko
Summary: The aim of this study was to evaluate the characteristics of a rapid immunochemical detection kit for orthopoxviruses. The kit showed high sensitivity and specificity, allowing for quick detection of the virus. Its simplicity and visual interpretation of results make it useful in various biosecurity settings.
Article
Chemistry, Medicinal
Karolina Vankova, Dianne T. Keough, Dana Hockova, Luke W. Guddat, Zlatko Janeba
Summary: Twelve N2'-branched acyclic nucleoside phosphonates and bisphosphonates were synthesized as potential inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT). The compounds showed low to modest selectivity for the parasite enzyme over human HGPRT. The effect of different chemical groups/linkers attached to N2' atom on inhibition constants and selectivity was discussed.
Article
Virology
Masmudur M. Rahman, Grant McFadden
Summary: Poxviruses are a diverse family of DNA viruses that can cause diseases in selective hosts. Some poxviruses can cross host species and pose a genuine threat to human and animal health. These viruses are able to adapt to new hosts and evade the host's immune response by expressing self-defense proteins. Different cytokines play a vital role in controlling the host tropism and adaptation of poxviruses.
CURRENT OPINION IN VIROLOGY
(2022)
Article
Pharmacology & Pharmacy
Lara Dsouza, Anil Pant, Samuel Offei, Lalita Priyamvada, Blake Pope, Panayampalli S. Satheshkumar, Zhengqiang Wang, Zhilong Yang
Summary: Trifluridine and adefovir dipivoxil are potent antiviral compounds against poxviruses, inhibiting viral replication and gene expression. They show promise in treating poxvirus infections, including monkeypox.
ANTIVIRAL RESEARCH
(2023)
Article
Chemistry, Medicinal
James R. Beadle, Nadejda Valiaeva, Guang Yang, Jei-Hwa Yu, Thomas R. Broker, Kathy A. Aldern, Emma A. Harden, Kathy A. Keith, Mark N. Prichard, Tracy Hartman, Robert W. Buckheit, Louise T. Chow, Karl Y. Hostetler
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Oncology
Kevin A. Cassady, David F. Bauer, Justin Roth, Melissa R. Chambers, Trent Shoeb, Jennifer Coleman, Mark Prichard, G. Yancey Gillespie, James M. Markert
MOLECULAR THERAPY-ONCOLYTICS
(2017)
Article
Pharmacology & Pharmacy
Karoly Toth, Jacqueline F. Spencer, Baoling Ying, Ann E. Tollefson, Caroll B. Hartline, Eric T. Richar, Jiajun Fan, Jinglei Lyu, Boris A. Kashemirov, Cheryl Harteg, Dawn Reyna, Elke Lipka, Mark N. Prichard, Charles E. McKenna, William S. M. Wold
ANTIVIRAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Debra C. Quenelle, Alexander Birkmann, Thomas Goldner, Tamara Pfaff, Holger Zimmermann, Susanne Bonsmann, Deborah J. Collins, Terri L. Rice, Mark N. Prichard
ANTIVIRAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
N. Sanjib Banerjee, Hsu-Kun Wang, James R. Beadle, Karl Y. Hostetler, Louise T. Chow
ANTIVIRAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Yohichi Kumaki, John D. Woolcott, Jason P. Roth, Tyler Z. Mclean, Donald F. Smee, Dale L. Barnard, Nadejda Valiaeva, James R. Beadle, Karl Y. Hostetler
ANTIVIRAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
William J. Britt, Mark N. Prichard
ANTIVIRAL RESEARCH
(2018)
Article
Medicine, Research & Experimental
Caroll B. Hartline, Ra'Shun L. Conner, Scott H. James, Jennifer Potter, Edward Gray, Jose Estrada, Mathew Tector, A. Joseph Tector, Mark N. Prichard
XENOTRANSPLANTATION
(2018)
Article
Pharmacology & Pharmacy
Caroll B. Hartline, Kathy A. Keith, Jessica Eagar, Emma A. Harden, Terry L. Bowlin, Mark N. Prichard
ANTIVIRAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Kathy A. Keith, Caroll B. Hartline, Terry L. Bowlin, Mark N. Prichard
ANTIVIRAL RESEARCH
(2018)
Article
Pharmacology & Pharmacy
James R. Beadle, Kathy A. Aldern, Xing-Quan Zhang, Nadejda Valiaeva, Karl Y. Hostetler, Robert T. Schooley
ANTIVIRAL RESEARCH
(2019)
Article
Microbiology
Michael K. Lo, Punya Shrivastava-Ranjan, Payel Chatterjee, Mike Flint, James R. Beadle, Nadejda Valiaeva, Joyce Murphy, Robert T. Schooley, Karl Y. Hostetler, Joel M. Montgomery, Christina F. Spiropoulou
Summary: The intravenous administration of remdesivir limits its use in treating COVID-19, while ODBG-P-RVn, an orally available prodrug with broad-spectrum antiviral activity, shows potential therapeutic effects and warrants further in vivo evaluation. This study highlights the importance of optimizing drug delivery to combat emerging viruses and diseases.
MICROBIOLOGY SPECTRUM
(2021)
Article
Pharmacology & Pharmacy
Mei Chen, Jiangping Hou, Guilin Tan, Peng Xie, William R. Freeman, James R. Beadle, Karl Y. Hostetler, Lingyun Cheng
Article
Pharmacology & Pharmacy
Donald F. Smee, Mark N. Prichard
ANTIVIRAL RESEARCH
(2017)
Article
Oncology
Haytham Khoury, Ruijuan He, Aaron Schimmer, James R. Beadle, Karl Y. Hostetler, Mark D. Minden