Indole-3-Carbinol Derivative DIM Mitigates Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Inflammatory Response, Apoptosis and Regulating Oxidative Stress

The Role of Nrf2 in Liver Disease: Novel Molecular Mechanisms and Therapeutic Approaches

(2019) Dongwei Xu et al.   Frontiers in Pharmacology

Umbelliferone prevents oxidative stress, inflammation and hematological alterations, and modulates glutamate-nitric oxide-cGMP signaling in hyperammonemic rats

(2018) Mousa O. Germoush et al.   BIOMEDICINE & PHARMACOTHERAPY

Diterpenoid trigonoreidon B isolated from Trigonostemon reidioides alleviates inflammation in models of LPS-stimulated murine macrophages and inflammatory liver injury in mice

(2018) Tanyarath Utaipan et al.   BIOMEDICINE & PHARMACOTHERAPY

Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride-induced acute liver injury by activating Nrf2 signaling pathway in mice

(2018) Chenqing Ning et al.   ENVIRONMENTAL TOXICOLOGY

Protective effect of the total flavonoids from Apocynum venetum L. on carbon tetrachloride-induced hepatotoxicity in vitro and in vivo

(2018) Wei Zhang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

3,3′-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro

(2018) Zun-En Xia et al.   RENAL FAILURE

A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations

(2018) Daniel C. Levings et al.   Redox Biology

3,3′-Diindolylmethane protects cardiomyocytes from LPS-induced inflammatory response and apoptosis

(2018) Qiang Luo et al.   BMC Pharmacology & Toxicology

Nrf2, the Master Regulator of Anti-Oxidative Responses

(2017) Sandra Vomund et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte-Specific c-met Deletion during the Progression of NASH

(2017) Pierluigi Ramadori et al.   Oxidative Medicine and Cellular Longevity

Hepatoprotective properties of Penthorum chinense Pursh against carbon tetrachloride-induced acute liver injury in mice

(2017) Meng Wang et al.   Chinese Medicine

Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation

(2016) Hwa-Young Lee et al.   BMC Complementary and Alternative Medicine

Parboiled Germinated Brown Rice Protects Against CCl4-Induced Oxidative Stress and Liver Injury in Rats

(2016) Kansuda Wunjuntuk et al.   JOURNAL OF MEDICINAL FOOD

Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine

(2016) Shuai Ji et al.   JOURNAL OF NATURAL PRODUCTS

Hepatoprotective effect of grape seed oil against carbon tetrachloride induced oxidative stress in liver of γ-irradiated rat

(2016) Amel F.M. Ismail et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Protective effects of silymarin, alone or in combination with chlorogenic acid and/or melatonin, against carbon tetrachloride-induced hepatotoxicity

(2016) AymanM Mahmoud et al.   Pharmacognosy Magazine

Inhibition of glycogen synthase kinase 3β promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor α

(2016) F Ren et al.   Cell Death & Disease

Indigofera oblongifolia Prevents Lead Acetate-Induced Hepatotoxicity, Oxidative Stress, Fibrosis and Apoptosis in Rats

(2016) Ahmed E. Abdel Moneim   PLoS One

3,3′-Diindolylmethane attenuates LPS-mediated acute liver failure by regulating miRNAs to target IRAK4 and suppress Toll-like receptor signalling

(2015) S Tomar et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Role of Oxidative Stress and Antioxidants in Liver Diseases

(2015) Sha Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice

(2015) Yi-Wei Cao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Natural Indoles, Indole-3-Carbinol (I3C) and 3,3’-Diindolylmethane (DIM), Attenuate Staphylococcal Enterotoxin B-Mediated Liver Injury by Downregulating miR-31 Expression and Promoting Caspase-2-Mediated Apoptosis

(2015) Philip B. Busbee et al.   PLoS One

Adenosine 5′-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice

(2014) Y Zhan et al.   Cell Death & Disease

Nuclear Factor (Erythroid-Derived 2)-Like-2 Factor (Nrf2), a Key Regulator of the Antioxidant Response to Protect Against Atherosclerosis and Nonalcoholic Steatohepatitis

(2013) Anisha A. Gupte et al.   Current Diabetes Reports

Hepatoprotective evaluation of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic: In vitro and in vivo studies

(2013) Guo Ai et al.   JOURNAL OF ETHNOPHARMACOLOGY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Protective Effect of Glycyrrhetinic Acid on Carbon Tetrachloride-Induced Chronic Liver Fibrosis in Mice via Upregulation of Nrf2

(2013) Shaoru Chen et al.   PLoS One

Adenosine induces cell cycle arrest and apoptosis via cyclinD1/Cdk4 and Bcl-2/Bax pathways in human ovarian cancer cell line OVCAR-3

(2013) Saeid Shirali et al.   TUMOR BIOLOGY

Glycyrrhizic acid attenuates CCl4-induced hepatocyte apoptosis in ratsviaa p53-mediated pathway

(2013) Xiao-Ling Guo   WORLD JOURNAL OF GASTROENTEROLOGY

The role of antioxidants and other agents in alleviating hyperglycemia mediated oxidative stress and injury in liver

(2013) Aparajita Dey et al.   Food & Function

The Role of Kupffer Cells in Carbon Tetrachloride Intoxication in Mice

(2012) Kaori Kiso et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Sanguinarine Induces Apoptosis of HT-29 Human Colon Cancer Cells via the Regulation of Bax/Bcl-2 Ratio and Caspase-9-Dependent Pathway

(2012) Jun Sik Lee et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Investigation of the Hepatoprotective Effects of Sesame (Sesamum indicum L.) in Carbon Tetrachloride-Induced Liver Toxicity

(2012) Nureddin Cengiz et al.   JOURNAL OF MEMBRANE BIOLOGY

Hispidin Analogue Davallialactone Attenuates Carbon Tetrachloride-Induced Hepatotoxicity in Mice

(2012) Prabodh Risal et al.   JOURNAL OF NATURAL PRODUCTS

Chrysin Modulates Ethanol Metabolism in Wistar Rats: A Promising Role against Organ Toxicities

(2011) M. Tahir et al.   ALCOHOL AND ALCOHOLISM

2,5-Hexanedione induces human ovarian granulosa cell apoptosis through BCL-2, BAX, and CASPASE-3 signaling pathways

(2011) Yan Sun et al.   ARCHIVES OF TOXICOLOGY

Wnt–β-catenin Signaling Protects Against Hepatic Ischemia and Reperfusion Injury in Mice

(2011) Nadja Lehwald et al.   GASTROENTEROLOGY

Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expression

(2011) CARMINE SPAMPANATO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Overexpression of peptidyl-prolyl isomerase Pin1 attenuates hepatocytes apoptosis and secondary necrosis following carbon tetrachloride-induced acute liver injury in mice

(2011) Prabodh Risal et al.   PATHOLOGY INTERNATIONAL

Alcohol-induced deterioration in primary antioxidant and glutathione family enzymes reversed by exercise training in the liver of old rats

(2010) K. Mallikarjuna et al.   ALCOHOL

Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor

(2010) Tsutomu Fujii et al.   BMC GASTROENTEROLOGY

Acute liver failure

(2010) William Bernal et al.   LANCET

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

(2009) Sudhir Chowdhry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration

(2008) Ghazaleh Aram et al.   HEPATOLOGY