CUL2 LRR1 , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle

Single-strand DNA breaks cause replisome disassembly

(2021) Kyle B. Vrtis et al.   MOLECULAR CELL

NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly

(2020) Kheewoong Baek et al.   NATURE

Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair

(2020) Niu Li et al.   NUCLEIC ACIDS RESEARCH

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

(2020) Tom D Deegan et al.   eLife

TRAIP is a master regulator of DNA interstrand crosslink repair

(2019) R. Alex Wu et al.   NATURE

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements

(2019) Lin Deng et al.   MOLECULAR CELL

Designing active RNF4 monomers by introducing a tryptophan: avidity towards E2∼Ub conjugates dictates the activity of ubiquitin RING E3 ligases

(2019) Sayani Sarkar et al.   BIOCHEMICAL JOURNAL

Once and Only Once

(2019) Susan Gasser   CELL

In Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast

(2019) Progya P. Mukherjee et al.   Cell Reports

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

(2019) Remi Sonneville et al.   eLife

Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication

(2019) Jacob S. Lewis et al.   MOLECULAR CELL

The mechanism of eukaryotic CMG helicase activation

(2018) Max E. Douglas et al.   NATURE

The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

(2018) Justin L. Sparks et al.   CELL

CRL2Lrr1promotes unloading of the vertebrate replisome from chromatin during replication termination

(2017) James M. Dewar et al.   GENES & DEVELOPMENT

Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates

(2017) Christoph F. Kurat et al.   MOLECULAR CELL

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis

(2017) Remi Sonneville et al.   NATURE CELL BIOLOGY

Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication

(2017) Marija Maric et al.   Cell Reports

Rapid DNA replication origin licensing protects stem cell pluripotency

(2017) Jacob Peter Matson et al.   eLife

Chromosome Duplication in Saccharomyces cerevisiae

(2016) S. P. Bell et al.   GENETICS

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

Inevitability and containment of replication errors for eukaryotic genome lengths spanning megabase to gigabase

(2016) Mohammed Al Mamun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells

(2016) Alberto Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Insights into the Mechanism of DNA Duplication by the Eukaryotic Replisome

(2016) Luca Pellegrini et al.   TRENDS IN BIOCHEMICAL SCIENCES

TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage

(2016) Nam Soo Lee et al.   Nature Communications

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

(2015) Daniel J. Anderson et al.   CANCER CELL

Evolutionary conservation of the CDK targets in eukaryotic DNA replication initiation

(2015) Philip Zegerman   CHROMOSOMA

TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress

(2015) Saskia Hoffmann et al.   JOURNAL OF CELL BIOLOGY

The mechanism of DNA replication termination in vertebrates

(2015) James M. Dewar et al.   NATURE

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

(2015) Margaret E Harley et al.   NATURE GENETICS

Constitutive heterochromatin formation and transcription in mammals

(2015) Nehmé Saksouk et al.   Epigenetics & Chromatin

DNA Replication and Oncogene-Induced Replicative Stress

(2014) Stephanie A. Hills et al.   CURRENT BIOLOGY

TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase  

(2014) H. A. Wallace et al.   DEVELOPMENT

TRAIP is a regulator of the spindle assembly checkpoint

(2014) C. Chapard et al.   JOURNAL OF CELL SCIENCE

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

(2014) Marija Maric et al.   SCIENCE

Polyubiquitylation drives replisome disassembly at the termination of DNA replication

(2014) Sara Priego Moreno et al.   SCIENCE

Dpb2 Integrates the Leading-Strand DNA Polymerase into the Eukaryotic Replisome

(2013) Sugopa Sengupta et al.   CURRENT BIOLOGY

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

(2013) Reggy Ekkebus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CRL2LRR-1 E3-Ligase Regulates Proliferation and Progression through Meiosis in the Caenorhabditis elegans Germline

(2013) Julien Burger et al.   PLoS Genetics

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

(2011) Yu V. Fu et al.   CELL

MCM2-7 Form Double Hexamers at Licensed Origins inXenopusEgg Extract

(2011) Agnieszka Gambus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CRL2LRR-1 ubiquitin ligase regulates cell cycle progression during C. elegans development

(2010) J. Merlet et al.   DEVELOPMENT

CRL2LRR-1 Targets a CDK Inhibitor for Cell Cycle Control in C. elegans and Actin-Based Motility Regulation in Human Cells

(2010) Natalia G. Starostina et al.   DEVELOPMENTAL CELL

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome

(2009) Agnieszka Gambus et al.   EMBO JOURNAL

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA