CRL2Lrr1promotes unloading of the vertebrate replisome from chromatin during replication termination

Chromatin Constrains the Initiation and Elongation of DNA Replication

(2017) Sujan Devbhandari et al.   MOLECULAR CELL

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication

(2017) Joseph T.P. Yeeles et al.   MOLECULAR CELL

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis

(2017) Remi Sonneville et al.   NATURE CELL BIOLOGY

DNA replication origins—where do we begin?

(2016) Marie-Noëlle Prioleau et al.   GENES & DEVELOPMENT

Chromosome Duplication in Saccharomyces cerevisiae

(2016) S. P. Bell et al.   GENETICS

Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase

(2016) Fabrizio Villa et al.   MOLECULAR CELL

USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication

(2016) Santiago Hernández-Pérez et al.   Molecular Oncology

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

(2016) André Franz et al.   Nature Communications

Tethering of SCFDia2 to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase

(2015) Timurs Maculins et al.   CURRENT BIOLOGY

Regulation of the Rev1-pol   complex during bypass of a DNA interstrand cross-link

(2015) M. Budzowska et al.   EMBO JOURNAL

Control of p97 function by cofactor binding

(2015) Alexander Buchberger et al.   FEBS LETTERS

TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress

(2015) Saskia Hoffmann et al.   JOURNAL OF CELL BIOLOGY

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

(2015) Huzefa Dungrawala et al.   MOLECULAR CELL

The mechanism of DNA replication termination in vertebrates

(2015) James M. Dewar et al.   NATURE

Systematic proteomics of the VCP–UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis

(2015) Malavika Raman et al.   NATURE CELL BIOLOGY

A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1

(2015) Luis J. García-Rodríguez et al.   NUCLEIC ACIDS RESEARCH

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

(2015) M. Raschle et al.   SCIENCE

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome

(2014) Aline C. Simon et al.   NATURE

Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork

(2014) Roxana E Georgescu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CMG helicase and DNA polymerase   form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication

(2014) L. D. Langston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

(2014) Marija Maric et al.   SCIENCE

Polyubiquitylation drives replisome disassembly at the termination of DNA replication

(2014) Sara Priego Moreno et al.   SCIENCE

Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex

(2013) N. Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulating DNA Replication in Eukarya

(2013) K. Siddiqui et al.   Cold Spring Harbor Perspectives in Biology

A Newly Uncovered Group of Distantly Related Lysine Methyltransferases Preferentially Interact with Molecular Chaperones to Regulate Their Activity

(2013) Philippe Cloutier et al.   PLoS Genetics

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway

(2012) Willem den Besten et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase   in rolling circle DNA synthesis

(2012) Y.-H. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

(2011) Yu V. Fu et al.   CELL

Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21

(2011) Yu Ye et al.   EMBO REPORTS

The Ubiquitin Regulatory X (UBX) Domain-containing Protein TUG Regulates the p97 ATPase and Resides at the Endoplasmic Reticulum-Golgi Intermediate Compartment

(2011) Charisse M. Orme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc48/p97 Mediates UV-Dependent Turnover of RNA Pol II

(2011) Rati Verma et al.   MOLECULAR CELL

A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction

(2011) Malavika Raman et al.   MOLECULAR CELL

CDC-48/p97 Coordinates CDT-1 Degradation with GINS Chromatin Dissociation to Ensure Faithful DNA Replication

(2011) André Franz et al.   MOLECULAR CELL

Hierarchical Binding of Cofactors to the AAA ATPase p97

(2011) Petra Hänzelmann et al.   STRUCTURE

The CRL2LRR-1 ubiquitin ligase regulates cell cycle progression during C. elegans development

(2010) J. Merlet et al.   DEVELOPMENT

RNAi-based screening identifies the Mms22L–Nfkbil2 complex as a novel regulator of DNA replication in human cells

(2010) Wojciech Piwko et al.   EMBO JOURNAL

The MMS22L-TONSL Complex Mediates Recovery from Replication Stress and Homologous Recombination

(2010) Lara O'Donnell et al.   MOLECULAR CELL

A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability

(2010) Brenda C. O'Connell et al.   MOLECULAR CELL

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome

(2009) Agnieszka Gambus et al.   EMBO JOURNAL

Proliferating Cell Nuclear Antigen Uses Two Distinct Modes to Move along DNA

(2009) Anna B. Kochaniak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnover

(2008) Gabriela Alexandru et al.   CELL

Polymerase Dynamics at the Eukaryotic DNA Replication Fork

(2008) Peter M. J. Burgers   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

(2008) Alessia Montagnoli et al.   Nature Chemical Biology