Non‐canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus

Noncanonical function of an autophagy protein prevents spontaneous Alzheimer’s disease

(2020) Bradlee L. Heckmann et al.   Science Advances

Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain

(2020) Inmaculada Serramito-Gómez et al.   Nature Communications

Influenza virus uses transportin 1 for vRNP debundling during cell entry

(2019) Yasuyuki Miyake et al.   Nature Microbiology

Current and future influenza vaccines

(2019) Seiya Yamayoshi et al.   NATURE MEDICINE

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

(2019) Yue Xu et al.   CELL

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

The β 2 Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes

(2018) Alexander Gluschko et al.   Cell Host & Microbe

The WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes

(2018) Katherine Fletcher et al.   EMBO JOURNAL

Calcium sequestration by fungal melanin inhibits calcium–calmodulin signalling to prevent LC3-associated phagocytosis

(2018) Irene Kyrmizi et al.   Nature Microbiology

The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis

(2018) Shashank Rai et al.   Autophagy

An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread

(2018) Joel M. J. Tan et al.   Nature Microbiology

LC3-Associated Phagocytosis and Inflammation

(2017) Bradlee L. Heckmann et al.   JOURNAL OF MOLECULAR BIOLOGY

An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection

(2017) K M Akram et al.   Mucosal Immunology

LC3-Associated Phagocytosis Is Required for Dendritic Cell Inflammatory Cytokine Response to Gut Commensal Yeast Saccharomyces cerevisiae

(2017) Dimitra Lamprinaki et al.   Frontiers in Immunology

Bacterial secretion system skews the fate of Legionella-containing vacuoles towards LC3-associated phagocytosis

(2017) Andree Hubber et al.   Scientific Reports

Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity

(2016) Tonia Akoumianaki et al.   Cell Host & Microbe

Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis

(2016) Qun Lu et al.   Cell Host & Microbe

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

(2016) Jennifer Martinez et al.   NATURE

The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1

(2016) Emilio Boada-Romero et al.   Nature Communications

Leishmania major Promastigotes Evade LC3-Associated Phagocytosis through the Action of GP63

(2016) Christine Matte et al.   PLoS Pathogens

Autophagy Proteins Promote Repair of Endosomal Membranes Damaged by the Salmonella Type Three Secretion System 1

(2015) Saskia Kreibich et al.   Cell Host & Microbe

Influenza virus-induced lung injury: pathogenesis and implications for treatment

(2015) Susanne Herold et al.   EUROPEAN RESPIRATORY JOURNAL

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Modulating the Innate Immune Response to Influenza A Virus: Potential Therapeutic Use of Anti-Inflammatory Drugs

(2015) Irene Ramos et al.   Frontiers in Immunology

V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation

(2014) Oliver Florey et al.   Autophagy

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection

(2014) J. R. Teijaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza A virus uses the aggresome processing machinery for host cell entry

(2014) Indranil Banerjee et al.   SCIENCE

Pathogenic potential of interferon αβ in acute influenza infection

(2014) Sophia Davidson et al.   Nature Communications

Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery

(2013) Rebecca Roberts et al.   Autophagy

High-Content Analysis of Sequential Events during the Early Phase of Influenza A Virus Infection

(2013) Indranil Banerjee et al.   PLoS One

Foot-and-Mouth Disease Virus Induces Autophagosomes during Cell Entry via a Class III Phosphatidylinositol 3-Kinase-Independent Pathway

(2012) S. Berryman et al.   JOURNAL OF VIROLOGY

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes

(2011) Oliver Florey et al.   NATURE CELL BIOLOGY

The Novel Membrane Protein TMEM59 Modulates Complex Glycosylation, Cell Surface Expression, and Secretion of the Amyloid Precursor Protein

(2010) Sylvia Ullrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenesis and Transmission of Triple-Reassortant Swine H1N1 Influenza Viruses Isolated before the 2009 H1N1 Pandemic

(2010) J. A. Belser et al.   JOURNAL OF VIROLOGY

Coxsackievirus Infection Induces Autophagy-Like Vesicles and Megaphagosomes in Pancreatic Acinar Cells In Vivo

(2010) C. C. Kemball et al.   JOURNAL OF VIROLOGY

NADPH Oxidase 2 Interaction with TLR2 Is Required for Efficient Innate Immune Responses to Mycobacteria via Cathelicidin Expression

(2009) C.-S. Yang et al.   JOURNAL OF IMMUNOLOGY

Activation of antibacterial autophagy by NADPH oxidases

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE