Article
Endocrinology & Metabolism
Wei Wang, Mengyun Xu, Jiayin Yue, Qilun Zhang, Xiaomin Nie, Yan Jin, Zhi Zhang
Summary: ASIC1a in the PVN may serve as a potential new target for the therapeutic intervention of metabolic disorders.
Article
Biochemistry & Molecular Biology
Yuki Narimatsu, Daichi Matsuura, Eiko Iwakoshi-Ukena, Megumi Furumitsu, Kazuyoshi Ukena
Summary: This study demonstrates that NPGL causes obesity in different mouse strains and plays a critical role in fat accumulation in adipose tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Alexandre Picard, Salima Metref, David Tarussio, Wanda Dolci, Xavier Berney, Sophie Croizier, Gwenael Labouebe, Bernard Thorens
Summary: Fgf15 neurons play a crucial role in the counterregulatory response to hypoglycemia by directly affecting hepatic glucose production and suppressing vagally induced glucagon secretion.
Article
Biochemistry & Molecular Biology
Bingyang Liu, Fu Chen
Summary: NPY activation of NPY5R promotes hepatic ApoA1 synthesis and secretion through the ERK1/2 and PKA signal transduction pathways. Therefore, NPY5R may be a potential therapeutic target for treating CVD by promoting cholesterol reverse transport.
Article
Biochemistry & Molecular Biology
Keisuke Fukumura, Yuki Narimatsu, Shogo Moriwaki, Eiko Iwakoshi-Ukena, Megumi Furumitsu, Kazuyoshi Ukena
Summary: NPGL overexpression promotes body weight gain and food intake in normal chow fed mice, but has little effect on high-fat diet fed mice. Overexpression of NPGL decreases blood glucose levels in high-fat diet fed mice 60 minutes after glucose administration, increases adipose tissue mass in normal chow fed mice, and reduces blood glucose and insulin levels in high-fat diet fed mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Keisuke Fukumura, Yuki Narimatsu, Shogo Moriwaki, Eiko Iwakoshi-Ukena, Megumi Furumitsu, Kazuyoshi Ukena
Summary: Under long-term high-fat diet conditions, overexpression of NPGL may play a role in avoiding metabolic disturbance by accelerating energy storage and suppressing excess fat accumulation in certain tissues, such as the eWAT.
Article
Endocrinology & Metabolism
Mouna El Mehdi, Saloua Takhlidjt, Melodie Devere, Arnaud Arabo, Marie-Anne Le Solliec, Julie Maucotel, Alexandre Benani, Emmanuelle Nedelec, Celine Duparc, Benjamin Lefranc, Jerome Leprince, Youssef Anouar, Gaetan Prevost, Nicolas Chartrel, Marie Picot
Summary: This study identifies a novel mechanism, the 26RFa/GPR103 system, in the hypothalamic regulation of glucose homeostasis, and provides evidence that this peptidergic system acts as a key relay for the central regulation of glucose metabolism by insulin.
Article
Pharmacology & Pharmacy
Daiki Ueda, Naomi Yonemochi, Tomohiro Kamata, Masahiro Shibasaki, Junzo Kamei, John L. Waddington, Hiroko Ikeda
Summary: This study found that social novelty preference was impaired in diabetic mice, and NPY neurons may be activated in diabetic mice, impairing social novelty preference by promoting glutamatergic function through Y-2 receptors.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaomin Cang, Yu Wang, Jia Zeng, Jingwen Gao, Qianqian Yu, Chunfeng Lu, Feng Xu, Jiaxi Lin, Jinzhou Zhu, Xueqin Wang
Summary: This study showed that C9orf72 interacts with and activates Cdc42 protein in IR-challenged hepatocytes, inhibiting lipophagy. Knockdown of C9orf72 may potentially be therapeutic for the treatment of IR.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Myrtille C. R. Gumbs, Leslie Eggels, Anna H. Vuuregge, Unga A. Unmehopa, Joram D. Mul, Susanne E. la Fleur
Summary: This study found that the effects of intra-LHA NPY on caloric intake vary depending on the consumption of a fat or sugar component in a free-choice diet. The study also revealed that baseline preference for the fat diet component modulates the effects of intra-LHA NPY in rats fed with a free-choice high-fat and high-sugar diet.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Andy Tran, Wenyuan He, Jim T. C. Chen, Leigh Wellhauser, Kathyrn E. Hopperton, Richard P. Bazinet, Denise D. Belsham
Summary: Consumption of a diet high in saturated fatty acids can lead to hypothalamic neuroinflammation, dysregulation of neuronal function, and induction of orexigenic neuropeptide Y (Npy). Intracellular metabolism of palmitate and metabolites like ceramide and phospholipids play a crucial role in mediating the effects of palmitate on Npy expression.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Cell Biology
Yinqiong Huang, Xiahong Lin, Shu Lin
Summary: This research over the past decade has suggested that the pathogenic mechanisms of metabolic syndrome involve both peripheral tissues and central metabolic regulation imbalances. The hypothalamus, particularly the arcuate nucleus, is highlighted as the control center for metabolic homeostasis and energy balance, with Neuropeptide Y neurons playing a crucial role in integrating peripheral metabolic signals with the brain center. The manuscript aims to provide an overview of Neuropeptide Y's regulatory effects on metabolic syndrome and discuss clinical intervention strategies for neurometabolic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Zhigang Shi, Alyssa C. Bonillas, Jennifer Wong, Stephanie L. Padilla, Virginia L. Brooks
Summary: The study reveals that NPY in the hypothalamus suppresses sympathetic nerve activity in brown adipose tissue and influences heart rate and blood pressure via Y1R. Downstream pathways for BAT SNA may involve direct projections to the RPa and PVN.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Kimberly W. Y. Mak, Wenyuan He, Neruja Loganathan, Denise D. Belsham
Summary: This study identified the first hypothalamic miRNA that directly targets the 3' UTR of mouse Npy, highlighting the involvement of miRNAs in the NPY system and providing an alternative target for control of NPY levels.
Article
Medicine, Research & Experimental
Maria Bove, Adriano Lama, Stefania Schiavone, Claudio Pirozzi, Paolo Tucci, Vladyslav Sikora, Giovanna Trinchese, Gaetano Corso, Maria Grazia Morgese, Luigia Trabace
Summary: Social isolation-induced insulin resistance and oxidative stress may contribute to disturbances in glucose homeostasis and metabolic impairment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Psychology, Biological
Zachary I. Grunewald, Sunhye Lee, Rebecca Kirkland, Matthew Ross, Claire B. de La Serre
PHYSIOLOGY & BEHAVIOR
(2019)
Article
Chemistry, Medicinal
Miaomiao Teng, Yimeng Zhou, Min Song, Kai Dong, Xiangguang Chen, Chengju Wang, Sheng Bi, Wentao Zhu
CHEMICAL RESEARCH IN TOXICOLOGY
(2019)
Article
Nutrition & Dietetics
Elizabeth A. Klingbeil, Carolina Cawthon, Rebecca Kirkland, Claire B. de La Serre
Article
Nutrition & Dietetics
Sunhye Lee, Rebecca Kirkland, Zachary I. Grunewald, Qingshen Sun, Louise Wicker, Claire B. de La Serre
Article
Environmental Sciences
Miaomiao Teng, Xiangguang Chen, Chen Wang, Min Song, Jie Zhang, Sheng Bi, Chengju Wang
ENVIRONMENT INTERNATIONAL
(2020)
Editorial Material
Neurosciences
Arashdeep Singh, Claire de la Serre, Guillaume de Lartigue
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Physiology
Molly McDougle, Danielle Quinn, Charlene Diepenbroek, Arashdeep Singh, Claire de la Serre, Guillaume de Lartigue
Summary: The study found that selective ablation of sensory vagal neurones innervating the gut plays a crucial role in the control of food intake, energy expenditure, and glucose homeostasis in response to different diets. This suggests that intact sensory vagal neurones prevent overeating and weight gain in response to a high-fat high-sugar diet by promoting lipid-mediated satiation.
Article
Endocrinology & Metabolism
Lin Chen, Zhiliang Wei, Kannie W. Y. Chan, Yuguo Li, Kapil Suchal, Sheng Bi, Jianpan Huang, Xiang Xu, Philip C. Wong, Hanzhang Lu, Peter C. M. van Zijl, Tong Li, Jiadi Xu
Summary: This study utilized onVDMP MRI to show reduced D-glucose uptake in the cortex of AD mice compared to wild-type mice, as well as impaired glucose transporter function on blood-brain and blood-CSF barriers in AD mice, indicating glymphatic system dysfunction. It also suggested that tau protein affects D-glucose uptake and glymphatic impairment in AD prior to the development of neurofibrillary tangle pathology.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Psychology, Biological
J. S. Kim, R. A. Kirkland, S. H. Lee, C. R. Cawthon, K. W. Rzepka, D. M. Minaya, G. de Lartigue, K. Czaja, C. B. de La Serre
PHYSIOLOGY & BEHAVIOR
(2020)
Article
Biochemistry & Molecular Biology
Carolina R. Cawthon, Claire B. de La Serre
Summary: CCK plays a crucial role in regulating feeding behavior and optimizing digestion and nutrient absorption. Diet-induced obesity results in reduced sensitivity to CCK, potentially leading to dysfunction of the CCK system.
Article
Environmental Sciences
Sen Yan, Sinuo Tian, Zhiyuan Meng, Miaomiao Teng, Wei Sun, Ming Jia, Zhiqiang Zhou, Sheng Bi, Wentao Zhu
Summary: Environmental pollutants such as nitenpyram during pregnancy can affect metabolic health in mouse offspring by increasing specific microbial strains and hydrogen sulfide concentration, leading to colonic mucosa destruction, intestinal inflammation, and NASH. These findings shed light on the crucial role of gut microbiota in the pathogenesis of NASH.
ENVIRONMENTAL POLLUTION
(2021)
Article
Psychiatry
Emily E. Noble, Christine A. Olson, Elizabeth Davis, Linda Tsan, Yen-Wei Chen, Ruth Schade, Clarissa Liu, Andrea Suarez, Roshonda B. Jones, Claire de la Serre, Xia Yang, Elaine Y. Hsiao, Scott E. Kanoski
Summary: Research indicates that excessive early life consumption of sugar negatively impacts memory function in rats during adulthood, affecting hippocampal-dependent memory function and altering the gut microbiome, including the abundance of specific Parabacteroides species. Enrichment of these bacterial taxa during adolescence impairs hippocampal-dependent memory in adulthood, while early life sugar consumption and Parabacteroides microbial enrichment lead to alterations in gene expression related to intracellular kinase, neurotransmitter signaling, metabolic function, neurodegenerative disease, and dopaminergic signaling pathways.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Nutrition & Dietetics
Allison W. Rautmann, Claire B. de la Serre
Summary: The gut microbiota plays a key role in modulating host physiology and behavior, particularly in relation to feeding behavior, energy balance, and obesity. Changes in microbiome composition due to diet can lead to weight gain, adiposity, and alterations in ingestive behavior. Research is focused on understanding the role of the microbiome in the development of obesity and using microbiome manipulation to reduce food intake and promote weight loss.
Meeting Abstract
Physiology
G. de Lartigue, M. McDougle, D. Quinn, A. Singh, C. Diepenbroek, C. de La Serre
Article
Psychology, Biological
Carolina R. Cawthon, Rebecca A. Kirkland, Shreya Pandya, Nigel A. Brinson, Claire B. de La Serre
PHYSIOLOGY & BEHAVIOR
(2020)