The critical role of CCK in the regulation of food intake and diet-induced obesity

Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain

(2020) Shin J. Lee et al.   Cell Reports

A neural circuit mechanism for mechanosensory feedback control of ingestion

(2020) Dong-Yoon Kim et al.   NATURE

Measurement of cholecystokinin in plasma with reference to nutrition related obesity studies

(2020) Jens F. Rehfeld   NUTRITION RESEARCH

Intact vagal gut‐brain signalling prevents hyperphagia and excessive weight gain in response to high‐fat high‐sugar diet

(2020) Molly McDougle et al.   Acta Physiologica

Cholecystokinin-1 receptor agonist induced pathological findings in the exocrine pancreas of non-human primates

(2020) Niels Chresten Berg Nyborg et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Satiety induced by bile acids is mediated via vagal afferent pathways

(2020) Xiaoyin Wu et al.   JCI Insight

Behavioural and neurochemical mechanisms underpinning the feeding-suppressive effect of GLP-1/CCK combinatorial therapy

(2020) Emma Roth et al.   Molecular Metabolism

High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue

(2019) Eline N. Kuipers et al.   Frontiers in Physiology

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

(2019) Fiona M. Gribble et al.   Nature Reviews Endocrinology

Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism

(2019) Xufei Zhang et al.   FASEB JOURNAL

Cholecystokinin Modulates the Mucosal Inflammatory Response and Prevents the Lipopolysaccharide-Induced Intestinal Epithelial Barrier Dysfunction

(2019) Rafael Simone Saia et al.   SHOCK

Long-acting CCK analogue NN9056 lowers food intake and body weight in obese Göttingen Minipigs

(2019) Berit Ø. Christoffersen et al.   INTERNATIONAL JOURNAL OF OBESITY

Purinergic receptor expression and function in rat vagal sensory neurons innervating the stomach

(2019) Emily N. Blanke et al.   NEUROSCIENCE LETTERS

Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity

(2019) Donovan A. Argueta et al.   Frontiers in Physiology

Genetic Identification of Vagal Sensory Neurons That Control Feeding

(2019) Ling Bai et al.   CELL

Potato-Resistant Starch Supplementation Improves Microbiota Dysbiosis, Inflammation, and Gut–Brain Signaling in High Fat-Fed Rats

(2019) Elizabeth A. Klingbeil et al.   Nutrients

Cholecystokinin (CCK) and related adjunct peptide therapies for the treatment of obesity and type 2 diabetes

(2018) Varun Pathak et al.   PEPTIDES

A gut-brain neural circuit for nutrient sensory transduction

(2018) Melanie Maya Kaelberer et al.   SCIENCE

A Neural Circuit for Gut-Induced Reward

(2018) Wenfei Han et al.   CELL

Molecular basis of action of a small molecule positive allosteric modulator (PAM)-agonist at the type 1 cholecystokinin holoreceptor

(2018) Aditya J. Desai et al.   MOLECULAR PHARMACOLOGY

The Functional and Neurobiological Properties of Bad Taste

(2018) Lindsey A. Schier et al.   PHYSIOLOGICAL REVIEWS

Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria

(2018) Elizabeth A. Kennedy et al.   Frontiers in Physiology

Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice

(2017) Farhana Naznin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Restoration of metabolic inflammation-related ghrelin resistance by weight loss

(2017) Farhana Naznin et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity

(2017) Donovan A. Argueta et al.   PHYSIOLOGY & BEHAVIOR

Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity

(2017) Tanusree Sen et al.   PHYSIOLOGY & BEHAVIOR

Distinct and common expression of receptors for inflammatory mediators in vagal nodose versus jugular capsaicin-sensitive/TRPV1-positive neurons detected by low input RNA sequencing

(2017) Jingya Wang et al.   PLoS One

Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient

(2016) Beth E. Taylor et al.   CRITICAL CARE MEDICINE

The Role of the Endocannabinoid System in the Brain–Gut Axis

(2016) Keith A. Sharkey et al.   GASTROENTEROLOGY

Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior

(2016) Pauline Luczynski et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Upregulation of inflammasome activity and increased gut permeability are associated with obesity in children and adolescents

(2016) V Rainone et al.   INTERNATIONAL JOURNAL OF OBESITY

Postprandial profiles of CCK after high fat and high carbohydrate meals and the relationship to satiety in humans

(2016) Catherine Gibbons et al.   PEPTIDES

Role of guar fiber in appetite control

(2016) Theertham Pradyumna Rao   PHYSIOLOGY & BEHAVIOR

Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids

(2016) Jung-ha Park et al.   PLoS One

Expression of the Bitter Taste Receptor, T2R38, in Enteroendocrine Cells of the Colonic Mucosa of Overweight/Obese vs. Lean Subjects

(2016) Rocco Latorre et al.   PLoS One

GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose Metabolism

(2016) Hua V. Lin et al.   PLoS One

Expression of cholecystokinin2-receptor in rat and human L cells and the stimulation of glucagon-like peptide-1 secretion by gastrin treatment

(2015) Yang Cao et al.   ACTA HISTOCHEMICA

Intraduodenal infusion of a combination of tastants decreases food intake in humans

(2015) Mark van Avesaat et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

PPG neurons of the lower brain stem and their role in brain GLP-1 receptor activation

(2015) Stefan Trapp et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

A Novel CCK-8/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions With Significant Therapeutic Potential in High-Fat–Fed Mice

(2015) Nigel Irwin et al.   DIABETES

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation

(2015) Farhana Naznin et al.   JOURNAL OF ENDOCRINOLOGY

Chronic exposure to Low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons

(2015) Claire B. de La Serre et al.   PHYSIOLOGY & BEHAVIOR

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Bitter Taste Receptor Agonist Quinine Reduces Calorie Intake and Increases the Postprandial Release of Cholecystokinin in Healthy Subjects

(2015) Paolo Andreozzi et al.   Journal of Neurogastroenterology and Motility

Activation of the GLP-1 Receptors in the Nucleus of the Solitary Tract Reduces Food Reward Behavior and Targets the Mesolimbic System

(2015) Jennifer E. Richard et al.   PLoS One

Synergistic metabolic benefits of an exenatide analogue and cholecystokinin in diet-induced obese and leptin-deficient rodents

(2014) J. L. Trevaskis et al.   DIABETES OBESITY & METABOLISM

The gastrointestinal metabolic effects of oat product based-β-glucan in mice

(2014) Ji-Lin Dong et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity

(2014) Guillaume de Lartigue et al.   Molecular Metabolism

Analyses of meal patterns across dietary shifts

(2013) Yada Treesukosol et al.   APPETITE

High fat diet and body weight have different effects on cannabinoid CB1 receptor expression in rat nodose ganglia

(2013) N.L. Cluny et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Direct and indirect effects of leptin on adipocyte metabolism

(2013) Ruth B.S. Harris   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Comparison of independent and combined metabolic effects of chronic treatment with (pGlu-Gln)-CCK-8 and long-acting GLP-1 and GIP mimetics in high fat-fed mice

(2013) N. Irwin et al.   DIABETES OBESITY & METABOLISM

Circadian Variation in Gastric Vagal Afferent Mechanosensitivity

(2013) S. J. Kentish et al.   JOURNAL OF NEUROSCIENCE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Overnight food deprivation markedly attenuates hindbrain noradrenergic, glucagon-like peptide-1, and hypothalamic neural responses to exogenous cholecystokinin in male rats

(2013) James W. Maniscalco et al.   PHYSIOLOGY & BEHAVIOR

Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca2+ Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity

(2013) Yusaku Iwasaki et al.   PLoS One

Correlations of macronutrient-induced functional magnetic resonance imaging signal changes in human brain and gut hormone responses

(2012) Jie Li et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effect of peripheral administration of cholecystokinin on food intake in apolipoprotein AIV knockout mice

(2012) Go Yoshimichi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of fat, protein, and carbohydrate and protein load on appetite, plasma cholecystokinin, peptide YY, and ghrelin, and energy intake in lean and obese men

(2012) Ixchel M. Brennan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion

(2012) Kristian Daly et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effect of different long-chain fatty acids on cholecystokinin release in vitro and energy intake in free-living healthy males

(2012) Charlotte J. Harden et al.   BRITISH JOURNAL OF NUTRITION

Apolipoprotein AIV Requires Cholecystokinin and Vagal Nerves to Suppress Food Intake

(2012) Chunmin C. Lo et al.   ENDOCRINOLOGY

A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin

(2012) Kristoffer L. Egerod et al.   ENDOCRINOLOGY

Gastric vagal afferent modulation by leptin is influenced by food intake status

(2012) Stephen J. Kentish et al.   JOURNAL OF PHYSIOLOGY-LONDON

Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids

(2012) Antonio Luchicchi et al.   MOLECULAR NEUROBIOLOGY

Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice

(2012) Yan Y. Lam et al.   PLoS One

Leptin Resistance in Vagal Afferent Neurons Inhibits Cholecystokinin Signaling and Satiation in Diet Induced Obese Rats

(2012) Guillaume de Lartigue et al.   PLoS One

Increased Oral Detection, but Decreased Intestinal Signaling for Fats in Mice Lacking Gut Microbiota

(2012) Frank A. Duca et al.   PLoS One

Duodenal Enteroendocrine I-Cells Contain mRNA Transcripts Encoding Key Endocannabinoid and Fatty Acid Receptors

(2012) Alexandros G. Sykaras et al.   PLoS One

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons

(2011) Guillaume de Lartigue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CCK Stimulation of GLP-1 Neurons Involves α 1 -Adrenoceptor–Mediated Increase in Glutamatergic Synaptic Inputs

(2011) Kazunari Hisadome et al.   DIABETES

Different tastants and low-caloric sweeteners induce differential effects on the release of satiety hormones

(2011) Maartje C.P. Geraedts et al.   FOOD CHEMISTRY

Requirement of phospholipase C and protein kinase C in cholecystokinin-mediated facilitation of NMDA channel function and anxiety-like behavior

(2011) Zhaoyang Xiao et al.   HIPPOCAMPUS

Synergistic Interaction between Leptin and Cholecystokinin in the Rat Nodose Ganglia Is Mediated by PI3K and STAT3 Signaling Pathways

(2011) Andrea Heldsinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse

(2011) Donna M. Daly et al.   JOURNAL OF PHYSIOLOGY-LONDON

Diet-induced adaptation of vagal afferent function

(2011) Stephen Kentish et al.   JOURNAL OF PHYSIOLOGY-LONDON

Vagal afferent neurons in high fat diet-induced obesity; intestinal microflora, gut inflammation and cholecystokinin

(2011) Guillaume de Lartigue et al.   PHYSIOLOGY & BEHAVIOR

Dietary conditions and highly palatable food access alter rat cannabinoid receptor expression and binding density

(2011) Nicholas T. Bello et al.   PHYSIOLOGY & BEHAVIOR

Mechanism of Action of Cholecystokinin on Colonic Motility in Isolated, Vascularly Perfused Rat Colon

(2011) Byeong-Seong Ko et al.   Journal of Neurogastroenterology and Motility

IFNγ-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells

(2010) Hans A. R. Bluyssen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype

(2010) Galina Burdyga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Low-affinity CCK-A receptors are coexpressed with leptin receptors in rat nodose ganglia: implications for leptin as a regulator of short-term satiety

(2010) Ying Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cholecystokinin/Cholecystokinin-1 Receptor-Mediated Peripheral Activation of the Afferent Vagus by Enteral Nutrients Attenuates Inflammation in Rats

(2010) Tim Lubbers et al.   ANNALS OF SURGERY

EGR1Is a Target for Cooperative Interactions between Cholecystokinin and Leptin, and Inhibition by Ghrelin, in Vagal Afferent Neurons

(2010) Guillaume de Lartigue et al.   ENDOCRINOLOGY

Vagal afferent innervation of the proximal gastrointestinal tract mucosa: Chemoreceptor and mechanoreceptor architecture

(2010) Terry L. Powley et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Dietary sodium butyrate supplementation increases digestibility and pancreatic secretion in young milk-fed calves

(2010) P. Guilloteau et al.   JOURNAL OF DAIRY SCIENCE

Additive effects of cannabinoid CB1 receptors blockade and cholecystokinin on feeding inhibition

(2010) L. Orio et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Hindbrain leptin receptor stimulation enhances the anorexic response to cholecystokinin

(2009) Diana L. Williams et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Age-related changes in vagal afferents innervating the gastrointestinal tract

(2009) Robert J. Phillips et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

A potential gastrointestinal link between enhanced postnatal maternal care and reduced anxiety-like behavior in adolescent rats.

(2009) Brittany C. Weber et al.   BEHAVIORAL NEUROSCIENCE

Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network

(2009) Grace W.C. Cheung et al.   Cell Metabolism

Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle

(2009) E.-G. Hong et al.   DIABETES

Cocaine- and Amphetamine-Regulated Transcript Mediates the Actions of Cholecystokinin on Rat Vagal Afferent Neurons

(2009) Guillaume De Lartigue et al.   GASTROENTEROLOGY

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Role of Fat Hydrolysis in Regulating Glucagon-Like Peptide-1 Secretion

(2009) Svetlana Beglinger et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Melanocortin-4 receptor expression in a vago-vagal circuitry involved in postprandial functions

(2009) Laurent Gautron et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Oat β-glucan increases postprandial cholecystokinin levels, decreases insulin response and extends subjective satiety in overweight subjects

(2009) Eleanor J. Beck et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide-1 in the rat

(2009) v. bucinskaite et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Cholecystokinin and gut–brain signalling

(2009) Graham J. Dockray   REGULATORY PEPTIDES

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Cholecystokinin Regulates Expression of Y2 Receptors in Vagal Afferent Neurons Serving the Stomach

(2008) G. Burdyga et al.   JOURNAL OF NEUROSCIENCE

The vagus nerve, food intake and obesity

(2008) Hans-Rudolf Berthoud   REGULATORY PEPTIDES