Article
Behavioral Sciences
Daiki Ueda, Naomi Yonemochi, Tomohiro Kamata, Junzo Kamei, John L. Waddington, Hiroko Ikeda
Summary: Diabetic mice showed impairment in social novelty preference, but not sociability. Enhanced glutamatergic function in both vHC and BLA impairs social novelty preference through AMPA receptors in diabetic mice, while increased NPYergic function in BLA impairs social novelty preference through NPY Y-2 receptors.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Aubrey M. Kelly, Ashley W. Seifert
Summary: VP and OT, two nonapeptides, play critical roles in modulating physiology and social behaviors across vertebrates, showing relatively strong evolutionary conservation in distributions. The distribution of VP and OT neurons in Acomys cahirinus, a gregarious rodent species, was examined, revealing both similarities and sex differences in neuronal populations compared to other rodents. These findings provide foundational knowledge for studying nonapeptide-mediated behavior in social rodents.
Article
Multidisciplinary Sciences
Hadassah Mendez-Vazquez, Regan L. Roach, Kaila Nip, Soham Chanda, Matheus F. Sathler, Tyler Garver, Rosaline A. Danzman, Madeleine C. Moseley, Jessica P. Roberts, Olivia N. Koch, Ava A. Steger, Rahmi Lee, Jyothi Arikkath, Seonil Kim
Summary: 6-catenin is expressed in excitatory synapses and functions as an anchor for the GluA2 subunit of the AMPAR in the postsynaptic density. The G34S mutation in the 6-catenin gene has been found in patients with autism spectrum disorder (ASD) and leads to loss of 6-catenin functions. The G34S mutation increases GSK3β-dependent degradation of 6-catenin, resulting in reduced levels of 6-catenin and altered glutamatergic activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Lidia Belles, Andrea Dimiziani, Stergios Tsartsalis, Philippe Millet, Francois R. Herrmann, Nathalie Ginovart
Summary: The study revealed a strong relationship between impulsivity and novelty preference in rats. The availability of D2/3 receptors in the striatum is closely associated with these traits, while dopamine release in both ventral and dorsal striatum further impacts this correlation.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Lora L. Martucci, Jean-Marie Launay, Natsuko Kawakami, Cecile Sicard, Nathalie Desvignes, Mbarka Dakouane-Giudicelli, Barbara Spix, Maude Tetu, Franck -Olivier Gilmaire, Sloane Paulcan, Jacques Callebert, Cyrille Vaillend, Franz Bracher, Christian Grimm, Philippe Fossier, Sabine de la Porte, Hirotaka Sakamoto, John Morris, Antony Galione, Sylvie Granon, Jose-Manuel Cancela
Summary: Oxytocin is released in response to Ca2+ influx and release from intracellular stores, both critical for priming large dense-cored vesicles in hypothalamic neurons for exocytosis. This study shows that lysosomes surround dendritic vesicles and activation of endolysosomal two-pore channels (TPCs) provides the necessary Ca2+ signals to prime oxytocin release. TPC knockout mice and mice lacking TPC exhibit impaired oxytocin secretion and social behavior, which can be restored by direct administration of oxytocin.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Huayue Liu, Xiaowen Meng, Yixuan Li, Shiwen Chen, Yumeng Ji, Shaoyong Song, Fuhai Ji, Xin Jin
Summary: This study investigated the effects of sevoflurane anesthesia in neonatal mice on social behavior. The results showed that mice undergoing sevoflurane anesthesia exhibited strong social capabilities and weak preference for social novelty in their juvenile age. In early adulthood, male mice recovered normal preference for social novelty, while female mice continued to show weak preference. The anesthesia also decreased the expression of PSD95 in the hippocampus of neonatal mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Neurosciences
Angel Baudon, Etienne Clauss Creusot, Ferdinand Althammer, Christian P. Schaaf, Alexandre Charlet
Summary: The neuropeptide oxytocin has been studied for its effects on physiology, neuronal circuits, and behaviors, particularly sociality. Recent studies have shown the existence and importance of astroglial oxytocin receptors in various brain regions. The role of astrocytic oxytocin receptors in neuromodulation and integrated brain functions still needs further investigation.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Manal Tabbaa, Ashley Moses, Elizabeth A. D. Hammock
Summary: The study revealed that OXTR specifically expressed in cells of neural crest origin play a significant regulatory role in social behavior and aggression in mice, highlighting future research directions.
Article
Psychology, Biological
Bianca Gomes do Nascimento, Caio Maximino
Summary: Social preference tests are useful for analyzing variables that influence social behaviors and investigating the effects of substances. They can help find valid models for studying neuropsychiatric changes and impaired neurodevelopmental processes caused by social events.
BEHAVIOURAL PROCESSES
(2023)
Article
Clinical Neurology
Wen-Jie Bian, Oscar C. Gonzalez, Luis de Lecea
Summary: This study reveals that the R1117X mutation in the Shank3 gene causes sleep defects in adolescent mice, which are associated with adult social behavior. The mutant mice exhibit altered electroencephalogram power and increased dopamine activity during REM sleep. These findings provide insights into the relationship between Shank3 gene involvement and sleep phenotypes in schizophrenia.
Article
Biochemistry & Molecular Biology
Noelia Sofia de Leon Reyes, Paula Sierra Diaz, Ramon Nogueira, Antonia Ruiz-Pino, Yuki Nomura, Christopher A. de Solis, Jay Schulkin, Arun Asok, Felix Leroy
Summary: Adult rodents prefer to interact with novel members of the same species rather than familiar ones. This study identifies neurons in the infra limbic area (ILA) of the mouse prefrontal cortex that express corticotropin-releasing hormone (CRH) and project to the dorsal region of the rostral lateral septum (rLS). The release of CRH during familiar encounters disinhibits rLS neurons, suppressing social interactions with familiar mice and contributing to the preference for social novelty.
Article
Biochemistry & Molecular Biology
Qingcai Chen, Wei Chu, Rui Sheng, Shaoyong Song, Jianping Yang, Fuhai Ji, Xin Jin
Summary: The study found that maternal anesthesia with sevoflurane could induce social interaction deficits in offspring mice, particularly impacting the preference for social novelty in a long-lasting manner.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Mouna El Mehdi, Saloua Takhlidjt, Melodie Devere, Arnaud Arabo, Marie-Anne Le Solliec, Julie Maucotel, Alexandre Benani, Emmanuelle Nedelec, Celine Duparc, Benjamin Lefranc, Jerome Leprince, Youssef Anouar, Gaetan Prevost, Nicolas Chartrel, Marie Picot
Summary: This study identifies a novel mechanism, the 26RFa/GPR103 system, in the hypothalamic regulation of glucose homeostasis, and provides evidence that this peptidergic system acts as a key relay for the central regulation of glucose metabolism by insulin.
Review
Food Science & Technology
Sze-Yen Tan, Caitlyn Hack, Cindy Yu, Isabella Rennick, James Ohanian, Marina Dezan, Nicole Mott, Rebecca Manibo, Robin M. Tucker
Summary: Individuals with diabetes may have decreased sensitivity to sweetness, leading to increased intake and difficulty in blood glucose management.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Neurosciences
Edel M. Hughes, Patricia Calcagno, Connie Sanchez, Karen Smith, John P. Kelly, David P. Finn, Michelle Roche
Summary: This study found differential effects of acute morphine administration on social behavior and immediate early gene expression in rats prenatally exposed to VPA compared to saline-exposed controls. Morphine had a smaller impact on sociability and social novelty preference behavior in VPA-exposed rats but affected immediate early gene expression in the hippocampus.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
C. Ardianto, N. Yonemochi, S. Yamamoto, L. Yang, F. Takenoya, S. Shioda, H. Nagase, H. Ikeda, J. Kamei
Article
Neurosciences
Hiroko Ikeda, Naomi Yonemochi, Chrismawan Ardianto, Lizhe Yang, Junzo Kamei
Article
Biochemistry & Molecular Biology
Naomi Yonemochi, Chrismawan Ardianto, Lizhe Yang, Shogo Yamamoto, Daiki Ueda, Junzo Kamei, John L. Waddington, Hiroko Ikeda
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Behavioral Sciences
Daiki Ueda, Naomi Yonemochi, Tomohiro Kamata, Junzo Kamei, John L. Waddington, Hiroko Ikeda
Summary: Diabetic mice showed impairment in social novelty preference, but not sociability. Enhanced glutamatergic function in both vHC and BLA impairs social novelty preference through AMPA receptors in diabetic mice, while increased NPYergic function in BLA impairs social novelty preference through NPY Y-2 receptors.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Hiroko Ikeda, Risa Mikami, Naomi Yonemochi, John L. Waddington
Summary: The regulation of glucose metabolism by central dopamine D2 receptors is altered in type 1 and type 2 diabetic models. In type 1 diabetic models, dopamine D2 receptor stimulation or blockade does not affect glucose levels, while in type 2 diabetic models, it causes hyperglycemia. Additionally, hypothalamic dopaminergic function and hepatic glycogenolysis are decreased in type 1 diabetic models, which reduces hyperglycemia induced by dopamine D2 receptor stimulation or blockade.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)